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诱导凋亡治疗
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  apoptosis inducing therapy
     Conclusion Livin isoform expression was detected in NSCLC. As molecular marker of lung adenocarcinoma,Livin may be served as a new target for apoptosis inducing therapy of NSCLC.
     结论 Livin异构体在非小细胞肺癌组织中表达 ,作为肺腺癌的分子标志物 ,可能成为肺癌诱导凋亡治疗的新靶点
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     Preliminary study on the arsenic trioxide induced Tca8113 cell apoptosis in the treatment of oral squamous cell carcinoma
     三氧化二坤诱导凋亡治疗口腔鳞状细胞癌的初步研究
     A lot of strages for treatment of tumor are based on involving the mechanism of apoptosis.
     诱导凋亡治疗将成为人类征服肿瘤的有力手段。
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     Inducing cell apoptosis have been the focus in curing oncosis .
     而通过诱导凋亡治疗肿瘤己成为当今的焦点,研究其作用机制是不可缺少的。
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     Conclusions It is indicated that Livin may play a significant role in the TCC development. Livin might be a biomarker for the detection of TCC and served as a new target for apoptosis-inducing therapy of TCC.
     结论Livin表达与TCC的发生有关,可作为TCC的分子标志物,可能成为TCC诱导凋亡治疗的新靶点。
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     Finally, lead to the articular cartilage
     诱导软骨细胞凋亡
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     To a certain extent, the therapy strategy for tumor is mostly aimed to induce apoptosis.
     从某种程度上来说,肿瘤治疗即是诱导凋亡治疗
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     The morphology of apoptosis cells were observed with conventional Giemsa staining and DAPI counterstained.
     诱导瘤细胞的凋亡及分化;
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     constraint-induced movement therapy,CI
     强制性诱导运动治疗
     Patients with myelodysplastic syndrome in Anti-apoptosis treatment
     抗凋亡治疗骨髓增生异常综合征
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This article concludes the progress of treating cancer by inducing apoptosis by Traditional Chinese Medicine in the last few years.

药物诱导恶性肿瘤细胞凋亡是近年肿瘤研究领域的一个重大进展 ,中药砷剂治疗白血病 (主要是急性早幼粒细胞白血病 )取得成功为这方面提供了范例和突破口。本文概述了近年中医药诱导凋亡治疗恶性肿瘤的研究概况 ,并提出一些如关于肿瘤辨证论治等方面问题的思考、启发。

ObjectiveTo observe the effica cy and toxicity of realgar on acute promyelocytic leukemia(APL).Methods A randomized trial was designed.Realgar was administered to 30 patients with APL.ResultsAmong all of 30 patients,28 patients(93.33%) achieved CR,2(6.67%) patients had NR.With a median follow-up of 46 months(6~6 1 months),3(10.71%) paitents relapsed and 25 patients(89.29%) had continuous CR in 28 patients who had CR,skin sensitity,pigmentation and increase of ALT was fo und in one patient respectively.ConclusionRealgar...

ObjectiveTo observe the effica cy and toxicity of realgar on acute promyelocytic leukemia(APL).Methods A randomized trial was designed.Realgar was administered to 30 patients with APL.ResultsAmong all of 30 patients,28 patients(93.33%) achieved CR,2(6.67%) patients had NR.With a median follow-up of 46 months(6~6 1 months),3(10.71%) paitents relapsed and 25 patients(89.29%) had continuous CR in 28 patients who had CR,skin sensitity,pigmentation and increase of ALT was fo und in one patient respectively.ConclusionRealgar has high rem ission rate,long survival rate,and little side effect.It is convenient and cheap for therapy.This is a new method to induce apoptosis of acute promyeloctic leuk emia.

目的 观察诱导凋亡剂瑞尔康 (雄黄 ,Realgar)治疗急性早幼粒细胞白血病 (APL)的效果和毒副反应。方法 随机应用瑞尔康治疗APL 3 0例。结果 完全缓解 (CR ) 2 8例 (93 3 3 % ) ,未缓解 (NR ) 2例(6 67% )。经 6~ 61个月 (平均 46个月 )巩固治疗、随访 ,2 8例缓解者中 ,复发 3例 (10 71% ) ,持续缓解者 2 5例 (89 2 9% )。皮肤过敏、色素沉着及ALT轻度升高者各 1例 (各 3 3 3 % )。结论 瑞尔康具有诱导缓解率及长期生存率高 ,可防治DIC出血及中枢神经系统白血病 ,优于骨髓移植、化疗及维甲酸的效果 ,且无明显毒副作用 ,可门诊治疗 ,不需化疗 ,经济方便 ,无痛苦等优点。为APL开辟了诱导凋亡治疗新途径

Objective To study the expression of two isoforms(i.e.Livinα & Livinβ) of Livin,a novel inhibitor of apoptosis protein(IAP)family member,in non small cell lung cancer(NSCLC) and to explore relationship between Livin expression and NSCLC histological types,and changes of its expression after radio and/or chemotherapy,respectively.Methods Livin mRNA and protein expression levels in NSCLC tissues were detected by reverse transcription polymerase chain reaction(RT PCR) and western blot assay,respectively.Results...

Objective To study the expression of two isoforms(i.e.Livinα & Livinβ) of Livin,a novel inhibitor of apoptosis protein(IAP)family member,in non small cell lung cancer(NSCLC) and to explore relationship between Livin expression and NSCLC histological types,and changes of its expression after radio and/or chemotherapy,respectively.Methods Livin mRNA and protein expression levels in NSCLC tissues were detected by reverse transcription polymerase chain reaction(RT PCR) and western blot assay,respectively.Results Livin mRNA and protein were expressed in 11 of 48 NSCLC cases(22.9%).The positive rate of Livin expression in lung adenocarcinoma reached 45.5%,much more than that of lung squamocellular carcinoma and large cell carcinoma( P <0.01).No Livin expression was detected in para cancerous or benign disease lung tissues.Radiotherapy and/or chemotherapy induced gene expression of Livin remarkably.Conclusion Livin isoform expression was detected in NSCLC.As molecular marker of lung adenocarcinoma,Livin may be served as a new target for apoptosis inducing therapy of NSCLC.

目的 探讨一种新的凋亡抑制蛋白 (inhibitorofapoptosisprotein ,IAP)Livin两种异构体Livinα和Livinβ在非小细胞肺癌 (NSCLC)组织中的表达及其与NSCLC组织类型、放化治疗的关系。方法 采用逆转录多聚酶链式反应 (RT PCR)检测NSCLC组织中Livinα和LivinβmRNA的表达 ,并用westernblot分析Livin蛋白的表达。 结果  4 8例NSCLC组织中Livin表达阳性率为 2 2 .9% ,其表达与NSCLC组织学类型相关 ,腺癌中Livin表达阳性率达 4 5 .5 % ,明显高于鳞癌和大细胞癌 (P <0 .0 1 ) ,而癌旁组织和良性疾病肺组织未检出阳性结果 ;Livin表达还与肿瘤治疗相关 ,放化治疗可明显诱导Livin表达 (P <0 .0 1 )。结论 Livin异构体在非小细胞肺癌组织中表达 ,作为肺腺癌的分子标志物 ,可能成为肺癌诱导凋亡治疗的新靶点

 
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