Result The contents of IL-6 and IL-10 were increased in the treatment group 1 than that in the control group 1 (P<0.05). The content of IL-6 in the treatment group 2 was increased than that in the control group 2 (P<0.05).
The 3-year survival rate of treatment group 1 was signif icantly higher than those of treatment group 2, and control group (71.1% vs. 50. 0%, and 45.6%, P < 0.05).
NF200+/Brdu+ and FITC-NF200 stained cells increased rapidly,there was difference between treatment group 2 and treatment group 1 or model group significantly(P<0.01,0.05).
Results: The total leukocyte increasing effective rate occurred in the treated group 1 was 75.00%, that in the treated group 2 was 88.89%, in the control group 1 was 54.55% and in the control group 2 was 58.33%.
③ Nerve electrophysiological data changes: Month 2 and 3, SNCV, MNCV and EPA were significantly higher in methylcobalamin+ insulin treated group 1 than in insulin treated group 1 (P < 0.05);
Two weeks after diabetic model was established, the sciatic tissue IGF-1 mRNA contents were obviously higher in methylcobalamin+ insulin treated group 1 than that in insulin treated group 1 (P < 0.05), but not significantly different from that in NC group;
Patients in the control group were given clinical treatment while those in treatment 1 group were given San Qo, rehabilitation training and electroacupuncture,and those in treatment 2 group were given hyperbaric oxygen based on treatment lgroup.
Metheds Sixty-one patients of acute myocardial infarction were randomly divided into three groups: simvastatin treatment 1 group (20 mg/d of simvastatin,n=21), simvastatin treatment 2 group (80 mg/d of simvastatin,n=23), regular teatment group(no lipid-lowering drugs, n=17).
To investigate cognitive function involved factors. Methods:80 patients with acute cerebral infarction of internal carotid system(ICS) were randomly divided into three groups,treatment 1 group and treatment 2 group and control group.
Methods: The rats were randomly divided into treatment 1 group (invigorating plus sedative prescription), tre atment 2 group(invigorating, sedative prescription plus rhubarb), trauma control group an d health c ontrol group. The animal models of fracture were established in the two treatmen t groups and trauma control group.
Methods: A total of 38 SD rats were divided into 4 groups: normal control group (group A, n=8), heart failure group (group B,n=10),cozaar treatment group Ⅰ(group C,n=10), and cozaar treatment group Ⅱ(group D, n=10).
METHODS After atherosclerosis model was successfully made, animals (Japanese big ear rabbits) were divided into 3 groups( placebo group, treatment group Ⅰ and treatment group Ⅱ).
The control group (30 cases) was treated by common liver protection therapy, treatment group Ⅰ (40 cases) by γ-interferon, treatment group Ⅱ by KF associated with γ- interferon.
Postoperative pulmonary complications and mortality in these patients with either a combined preoperative treatment (group 1, n=11) or chemotherapy alone (group 2, n=9) are evaluated in the present paper.
We classified patients into those showing a ≥5% increase in LV ejection fraction (LVEF) at 3 months compared with LVEF values before the treatment (group 1,n=7) and those showing a >amp;lt;5% increase in LVEF (group 11,n=6).
On the other hand, administration of avidin 4 h after administration of the B-liposomes dramatically reduced the blood level so that it was only 5% of that in the non-treated group 1 h later.
Although anatomical outcomes were better in the operatively treated group (1.6?mm vs 2.9?mm displacement at end of follow-up, p=0.001), there was no difference in neurological recovery.
Control groups in which the defects were not treated (group 1), treated with collagen only (group 2), or treated with collagen and nontransduced MSCs (group 3) showed little or no osseous healing.
In the deferoxamine-treated group 1 dog was excluded for hypotension in the preischemic period.
(1) White mice were exposed to 40 cercariae of Schistosoma japonicum on the abdomen for 3, 5, 10, 15 and 20 minutes. Five weeks later, mice were killed and searched for worms. The percentage of worms recovered in the 5-minute group was found to be low (33%), whereas the differences between those in the 10-minute (45%), 15-minute (51%) and 20-minute (54%) groups were non-significant. (2) Infected mice were treated with tartar emetic given by mouth for 2 weeks. After a holding period of 1, 2, 3 or 4 weeks, mice...
(1) White mice were exposed to 40 cercariae of Schistosoma japonicum on the abdomen for 3, 5, 10, 15 and 20 minutes. Five weeks later, mice were killed and searched for worms. The percentage of worms recovered in the 5-minute group was found to be low (33%), whereas the differences between those in the 10-minute (45%), 15-minute (51%) and 20-minute (54%) groups were non-significant. (2) Infected mice were treated with tartar emetic given by mouth for 2 weeks. After a holding period of 1, 2, 3 or 4 weeks, mice were sacrificed. The differences between the number of worms remained in the 4 groups of mice were non-significant. Therefore, one week may be adopted as the holding period in the screening test for antimonials. (3) In the control group and in the treated group with tartar emetic 270 mg/kg/day, there was no significant difference between the number of worms remained in male and in female mice. But in the treated group with tartar emetic 170 mg/kg/day, the number of worms remained in female mice was less than that in male mice. Hence it is advisable to use equal number of both sexes of mice in experimental therapy. (4) After the treatment with tartar emetic, mice were divided into 2 grades according to the body weights. The number of worms remained in mice of the 2 grades revealed a significent difference only in the group with holding period of 3 weeks, but not in other groups.
(1) In 12 apparently healthy monkeys, the average respiratory rate was 46/minute, heart rate 227/minute, systolic/diastolic pressures 155/123 mm Hg, rectal temperature 39.0℃, erythrocytes 5.3 millionscu mm, leukocytes 15700 cu mm, among which lymphocytes 50.8%, neutrophils 45.0%, monocytes 2.0%, eosinophils 1.6%, and basophils 0.6%. (2) Sb-11 (H_2O_3Sb SCH_2COONa) is a pentavalent antimonial salt of stibonic acid. Intravenous injections at the daily dosage of 10 mg/kg in monkeys for 3 or 6 weeks produced no...
(1) In 12 apparently healthy monkeys, the average respiratory rate was 46/minute, heart rate 227/minute, systolic/diastolic pressures 155/123 mm Hg, rectal temperature 39.0℃, erythrocytes 5.3 millionscu mm, leukocytes 15700 cu mm, among which lymphocytes 50.8%, neutrophils 45.0%, monocytes 2.0%, eosinophils 1.6%, and basophils 0.6%. (2) Sb-11 (H_2O_3Sb SCH_2COONa) is a pentavalent antimonial salt of stibonic acid. Intravenous injections at the daily dosage of 10 mg/kg in monkeys for 3 or 6 weeks produced no cough, nausea, vomiting, anorexia or other reactions. Likewise, Sb-11 had no significant influence on the respiration, blood pressure, EXG, temperature, and the blood cell counts. (3) Five monkeys were each infected with 300 cercariae of Schistosoma japonicum. Beginning on the 43rd day after the infection, Sb-11 was given intravenously on 3 monkeys at the dosage of 10 mg/kg/day for 3 weeks. The remaining 2 monkeys served as control. After a holding period of another 4 weeks, the monkeys were autopsied. The numbers of the helminths remained in the 3 monkeys of the medicated group were 0, 1 and 13 respectively, with the schistosomes all degenerated, while those of the control group were 81 and 138 respectively. So the therapeutic effect of Sb-11 was vory remarkable. (4) The toxicity of Sb-11 was rather low. Drug tolerance to Sb-11 developed quickly in monkeys; which showed no toxic manifestations after a course as long as 6 weeks. Hence Sb-11 is recommended to be tried clinically on those patients who cannot receive intensive treatment of tartar emetic.
The effects of combined treatment of Sb-71 with some metal salts such as cupric sulfate, magnesium sulfate, zinc sulfate, cupric chloride, magnesium chloride and zinc chloride were investigated in mice bearing Ehrlich ascites carcinoma. It was found that simultaenous administrations of Sb-71 (15 mg/kg) and cupric sulfate (1.5-3 mg/kg) produced a marked potentiation of inhibition of the growth of the carcinoma, and prolonged significantly the survival time of the mice. The density and the total number of ascites...
The effects of combined treatment of Sb-71 with some metal salts such as cupric sulfate, magnesium sulfate, zinc sulfate, cupric chloride, magnesium chloride and zinc chloride were investigated in mice bearing Ehrlich ascites carcinoma. It was found that simultaenous administrations of Sb-71 (15 mg/kg) and cupric sulfate (1.5-3 mg/kg) produced a marked potentiation of inhibition of the growth of the carcinoma, and prolonged significantly the survival time of the mice. The density and the total number of ascites carcinoma cells were considerably decreased than those in the group treated with Sb-71 alone. Cupric sulfate alone at dosages of 1.5-3 mg/kg/day had no therapeutic effect on Ehrlich ascites carcinoma. Magnesium sulfate, zinc sulfate, cupric chloride and magnesium chloride did not influence the carcinostatic activity of Sb-71, whereas zinc chloride showed some antagonistic action against the therapeutic effect of Sb-71.
治疗组
treatment group 1
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