Objective To investigate the effect of intrathecal administration of ω-conopeptide SO3,a new N-type calcium channel blocker,on the expression of CGRP and substance P in the spinal cord of a rat model of chronic constriction injury(CCI).
2. The P-type (maybe including Q-type) calcium channel accounted for 50% calcium influx into synaptosomes, N-type for about 20%,while L-type didn't change KCl-induced increased intrasynaptosomal calcium concentrations.
2. Pancuronium of lower concentrations (1-40 P mol ?L"1) potentiated the N~type calcium currents dose-dependently without affecting the activating characteristic while higher concentration ( 100 u mol ?L"1 and higher) inhibited the N-type calcium currents.
P/Q-type cal-cium channel antagonist ω-agatoxin IVA had no different effects on increased intrasynaptosomal calcium concentrations with or without 100 μmol/L etomidate,but for N- or L-type cal-cium channel antagonist,it had additional effects when with etomidate.
Methods: Rat peritoneal macrophages were gathered and separated into four groups: ①Negative control: macrophages treated with α-Bungarotoxin (α-Bgt),special antagonist of α7 subunit of nicotinic cholinergic receptor (α7nAChR).
P/Q-type calcium channel antagonist co-agatoxin IVA had no different effects on increased intrasynaptosomal calcium concentrations with or without 100uM etomidate, but for N- or L-type calcium channel antagonist,it had additional effects when with etomidate.
Since wavelet bases are not available for this general setting, the new idea used here is to apply the discrete Calderón-type reproducing formula associated to para-accretive functions developed in [14].
However, the ECV measurement of dopant concentration in the underlying lightly doped n-type substrate is significantly influenced by the upper heavily-doped layer.
Segmentation of p-n junction was performed by implantation of boron (for the n-type Ge) and mechanical grooving of the Li diffusion layer (for the p-type Ge).
The effect of the total saponins of panax notogiseng ( PNS ) on transmitter release was studied on mouse diaphragm. The Ca2+ -mediated release evoked by electric stimulation at the nerve terminal or by raised K+ level was markedly reduced by Cd2 + , but not affected by PNS & nifedipine. Also, PNS didn't change the basic frequency of mepp & the Ba2+ entry during depolarization of the terminal. C-ompared with PNS, Cd2 had a significant effect on decreasing Ba2+ entry. These results suggest that PNS can not ch...
Comparing the rate of polymerization of Cephalosporins with a different structure at C3 or(and) C7 substituent, it is found out that both C3 and C7 substituent could influence the rat of the polymerizacion of type N. The more 7-substituent attracts electrons strongly, the easier the polymerization goes on. However, the inductive effect of 3-substituent influencing the polymerization has a limit, below which raising the effect of attracting electrons of 3-substituent increases the polymerization and above wh...
On isolated nonuniform stretched muscle preparation (INSMP) of rat diaphragm, it was found that the sustained depolarization (SD) in endplate area is the predominant response to repetitive stimu1ation after soman intoxication. Both the microelectrode intracellular recording and the extracellular acetylcholine (ACh) iontophoresis were used to investigate the mechanism of SD.The amplitude of ACh potential was used as the criterion of N-ACh receptor to ACh. ACh potential as well asendplate potential could not ...