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药物包裹
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  potential encapsulation
     The change of Zeta potential,encapsulation efficiency,drug loading and in vitro release of nanocapsules were investigated using BSA as a model drug.
     并以牛血清白蛋白为模型药物考察了药物包裹率和载药量的变化以及载药纳米微囊在磷酸缓冲溶液中的体外释放行为 .
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  “药物包裹”译为未确定词的双语例句
     Result Fluorouracil nanoemulsion was spherical in shape,its diameter was 20±10nm,the encapsulation of Fluorouracil in nanoemulsion was 85.06%,50% of the drug was released after 11 hours,95% of the drug was sustained to release in 50 hours.
     结果纳米乳剂颗粒为圆形或椭圆形,粒径范围20±10nm,药物包裹率85.06%,体外11h药物释放50%,50h缓释95%。
短句来源
     Result Large diameter Fluoroaracil gelatin microsphere was homogeneous with average diameter(232±32)μm,the encapsulation of Fluoroaracil was 85%and drug content was 12.2%,95% of the drug was sustained release in 48 hours.
     结果 大粒径氟尿嘧啶明胶微球粒径均匀 ,平均粒径 (2 32± 32 ) μm ,药物包裹率85 % ,载药量 12 .2 % ,体外 4 8h缓释 95 %。
短句来源
     Encapsulation ratewas 85.0%, and drug content was 12.2%.
     5-Fu明胶微球及所载化疗药物性质稳定,药物包裹率85.0%,载药率12.2%。
短句来源
     Results: The diameter of 5 Fu gelatin microspheres could be effectively controlled. The encapsulation rate was 85%, and drug content was 12.2%. 95% of the drug was sustained release in 4 hours.
     结果 :5 - Fu明胶微球颗粒直径均匀 ,药物包裹率 85 % ,载药率 12 .2 % ,体外 4h内缓释 95 %。
短句来源
     The gelatin microspheres loaded with norfloxacin were prepared by means of reverse phase suspension cold-condensation method using Fe3O4 as core, The products were characterized by SEM,TEM,drug loading rate, drug release behavior and microspheres degradation.
     以诺氟沙星为水溶性模型药物,采用反相悬液冷冻凝聚法制得包裹Fe3O4微粒和药物的磁性明胶微球,考察了磁性载药微球的制备条件对微球的成球率、药物包裹率、体外释药及微球降解情况的影响.
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     Drug Patches
     药物贴片
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     Drug Addiction
     药物成瘾性
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     The results showed that this new type of liposome is easy to disport and store, and convenient for coating the targeted drug.
     结果和结论 冻干法制备的脂质体便于运输、贮存,药物包裹简易。
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     The entrapment is up to 54. 0%.
     脂质体对药物包裹率可达54.0%,制剂比较稳定。
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     Research on the Pigment of Occlusion
     包裹色料的研究
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  drug encapsulation
The particle size and size distribution showed close relation to the surface coating, which may also be responsible for the drug encapsulation efficiency and the in vitro release kinetics.
      
The drug encapsulation efficiency and the drug release behavior in vitro conditions of camptothecin were measured by high performance liquid chromatography (HPLC).
      
The objective is to design a varying-porosity circular disc with outer region being denser acting as diffusion barrier region and inner more porous region acting as drug encapsulation region.
      
The effects of several parameters on particle size, drug encapsulation efficiency and drug release were investigated.
      
Drug encapsulation efficiency depended upon drug concentration, ethanol concentration, and phthalocyanine sulfonation degree and reached 100% in some cases.
      
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  potential encapsulation
The choice of potential encapsulation materials is enormous but often only limited data exists regarding their safety or potency.
      


In the present paper, the relationship between physico-chemical properties of lecithin and encapsulation ratio of methotrexate (MTX) in liposome was studied. For two kinds of lecithin (egg lecithin and soybean lecithin) after storage for different length of times, their oxidation index, iodine value, ultraviolet absorption and thin-layer chromatography were examined. Using double emulsify evaporation method, MTX-liposomes were prepared from lecithin of different oxidation index and their encapsulation ratio...

In the present paper, the relationship between physico-chemical properties of lecithin and encapsulation ratio of methotrexate (MTX) in liposome was studied. For two kinds of lecithin (egg lecithin and soybean lecithin) after storage for different length of times, their oxidation index, iodine value, ultraviolet absorption and thin-layer chromatography were examined. Using double emulsify evaporation method, MTX-liposomes were prepared from lecithin of different oxidation index and their encapsulation ratio of MTX were determined. In our experiment, it is shown that encapsulation ratio of MTX-liposome decreased with increasing oxidation index and iodine value of lecithin. After a long time of storage, both oxidation index and iodine value of lecithin increased and thin-layer chromatograms showed non-homogeneity. The results suggest that using lecithin With oxidation index below 0.2, iodine value about 60 and homogeneous thin layer chromatography a higher encapsulation ratio of MTX-liposome was obtained.

本文研究了卵磷脂的理化性质与MTX脂质体包裹率的关系。分别测定了两种卵磷脂(大豆卵磷脂、蛋黄卵磷脂)的氧化指数、碘价、紫外吸收光谱及薄层层析,并用具有不同氧化指数的卵磷脂用二次乳化蒸发法制备MTX脂质体,测定它们包裹MTX的百分率。初步表明:卵磷脂对药物包裹率随其氧化指数的升高而降低,同时薄层层析的杂质点亦增多。实验结果提示,用氧化指数在0.2以下,碘价在60左右,以及薄层层析一个点的卵磷脂制备MTX脂质体可以得到较高的包裹率。

In this paper, preparation of Levamisole-liposomes was reported. The factorsaffecting the encapsulation ratio of LMS-liposomes and their stability were studied. A fast andeasy method for determining LMS-liposomes was established. The results suggested that LMS-liposomes with 20% encapsulation ratio can be obtained. The important factors affecting LMS-liposomes stability were cholesterol content in liposomes and the ratio of drug to liposome, etc.Ten percent of entrapped LMS was not retained after sterilization...

In this paper, preparation of Levamisole-liposomes was reported. The factorsaffecting the encapsulation ratio of LMS-liposomes and their stability were studied. A fast andeasy method for determining LMS-liposomes was established. The results suggested that LMS-liposomes with 20% encapsulation ratio can be obtained. The important factors affecting LMS-liposomes stability were cholesterol content in liposomes and the ratio of drug to liposome, etc.Ten percent of entrapped LMS was not retained after sterilization at 100℃ for 30 min.

应用注入法制备了位径为250±21nm的左旋咪唑大单层脂质体,并获得20%以下的药物包裹率.包裹率受药脂比和脂质组成的影响.制备脂质体的有机相、脂质成分是影响左旋咪唑脂质体稳定性的重要因素.综合结果表明,以氯仿为有机相,药脂比定为1:100(W/W),脂质成分比为卵磷脂:胆固醇=5:1时,用100℃煮沸灭菌药物渗漏小于10%,且贮存稳定,是制备左旋咪唑脂质体的适宜条件.灭菌后,脂质体的形态经电镜观察无明显变化.

Multiple emulsion (w/o/w) containing etoposide was formulatedby orthogonal design to screen oils,emulsifiers (and HLB Value),stabilizers.Its drug inclusion rate,leakage rate and particle size were determined.Theresults showed that the multiple emulsion has good stability.

通过对油的品种、乳化剂及 HLB 值、稳定剂等辅料的筛选,并经正交设计试验获得较稳定的 W_1o/w_2型依托泊甙复乳处方和制备工艺条件,测定了药物包裹率并考核了稳定性。

 
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