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代表药物
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  representative drug
     The results of biological screening showed that compounds(Ⅰ) and (Ⅱ)had analgesic activity. The analgesic value of compound(Ⅰ)(ED 50 =7 7 mg/kg,( s.c ) was slightly higher than that of Dolantin which is the representative drug of Pethidine type analgesic drugs.The compound(Ⅰ)will become a leading compound for designing new analgesic drugs.
     生物筛选结果表明 :化合物 (Ⅰ )和 (Ⅱ )具有显著的镇痛活性 ,其中化合物 (Ⅰ )的镇痛效价 (ED50 =7 7mg/kg ,s.c)高于哌替啶代表药物度冷丁 ,有希望成为新的先导化合物 .
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     In this article, the pharmacology, pharmacokinetics, and clinical use of recombinant hirudin and its representative drug——lepirudin are introduced.
     本文对重组水蛭素及其主要代表药物lepirudin的药理作用、药动学、临床应用等作一介绍
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     Atosiban is a representative drug of oxytocin receptor antagonists and has a good effect on preterm's treatment.
     Atosiban是催产素受体阻断药的代表药物 ,对于早产的治疗有很好的疗效。
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     AIM: To observe the therapeutic effects of psychotherapy plus fluoxertine hydrochloride capsule, which is a representative drug of serotonin reabsorptive inhibitor, on heart neurosis.
     目的:观察心理治疗的同时合并5-羟色胺重吸收抑制剂的代表药物盐酸氟西汀胶囊对心脏神经官能症的治疗效果。
短句来源
     CONCLUSION: In the treatment of heart neurosis, psychotherapy plus fluoxertine hydrochloride capsule, which is a representative drug of serotonin reabsorptive inhibitor, play an obvious and active role in relieving the symptoms.
     结论:在心脏神经官能症的治疗中采用心理治疗合并5-羟色胺重吸收抑制剂的代表药物盐酸氟西汀胶囊治疗对症状的缓解有明显而积极的作用。
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  representative drugs
     METHODS: By collecting the literatures and making aggregate analysis of 8 representative drugs depending on the classifications of macrolides,quinolones and tetracyclines.
     方法 :查阅相关文献 ,按大环内酯类、喹诺酮类、四环素类分类对 8种代表药物进行综合分析。
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  “代表药物”译为未确定词的双语例句
     There were the protein drugs PEGylation such as adenosin deaminase, a -2b-interferon, a -2a-interferon, etc.
     聚乙二醇的代表药物有:腺苷脱氨酶、干扰素α-2b和干扰素α-2a等。
短句来源
     Transfected cells were cultured with known PPAR-γ activator pioglitazone 30μmol·L-1 or resveratrol 15 and 30μmol · L-1 for 24 h. Cells were lysated and assayed for reporter luciferase activity, which presented the drug capability to activate.
     转染细胞中加入已知PPAR-γ的激动剂吡格列酮30μmol·L-1和15,30μmol·L-1的白藜芦醇,培养24h后裂解细胞,测定细胞内报告质粒所表达虫荧光素酶的活性,该活性大小即代表药物激动PPAR-γ的能力。
短句来源
     The pharmacological activities of thalidomide (Thd), dapsone (DDS), indomethacin (IND), clobetasol prapionate (CP), which were known as anti-inflammatory or antiangiogenesis drugs, as well as triptolide (T_0) and ABC, which were related compounds with possible anti-inflammatory activity were detected.
     所检测的药物包括临床上已知的具有抗炎和抗血管生成活性的代表药物,如沙利度胺(Thd)、氨苯砜(DDS)、消炎痛(IND)、丙酸氯倍他索(CP),以及临床具有抗炎疗效、但药理作用还未弄清的线索化合物雷公藤内酯醇(T_0)和专利化合物ABC。
短句来源
     The typical agents of β lactams, aminoglycosides and quinolones didn't show any effect on PMN apoptosis in vitro.
     而体外实验显示除大环内酯抗生素外,β-内酰胺类、氨基糖甙类、喹诺酮类的代表药物均未显示有促进PMN凋亡的作用。
短句来源
     The prevalence rate of side effects was 68.18%,similar to that of chlorprothixene.
     药物副反应发生率为68.18%,与硫杂蒽类代表药物泰尔登相似。
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  representative drug
Finally, some representative drug effects are shown indicating that certain drugs may selectively affect the two types of bias.
      
The mass spectral behaviour of some representative drug-glucuronides (Codeine, p-Nitrophenol and 2-Phenyl-1-propanol) were studied by positive- and negative-ion-FAB-MS.
      
Spheroid survival and growth are monitored following PDT at representative drug concentrations, light doses, and dose rates.
      
A representative drug-induction experiment with colchicine after 3 days is shown.
      
IUdR was selected as a representative drug because of the availability of a radioiodinated derivative.
      
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  representative drugs
Representative drugs from the classes of DNA-active agents, alkylating agents, spindle poisons, and antimetabolites were tested.
      
Representative drugs mentioned in this article are listed in Table 2.
      


Pinacidil,a new antihypertensive agent develoed from pyridylthiourea derivatives, is a typical of potassium channel openers.By using pinacidil as lead compeund and co the basis of the structure-activity retationshipo in this series,4 thiourea(TC 01~TC 04) and 8 cyanoguanidine analogucs(PC 01~PC 08) of pinacidil were designed and synthesized in order to search for novel antihpertensive agents.The chemical structures of all the new compounds were identified by elemental analysis,IR,MS and 1HNMR. Preliminary pharmacological...

Pinacidil,a new antihypertensive agent develoed from pyridylthiourea derivatives, is a typical of potassium channel openers.By using pinacidil as lead compeund and co the basis of the structure-activity retationshipo in this series,4 thiourea(TC 01~TC 04) and 8 cyanoguanidine analogucs(PC 01~PC 08) of pinacidil were designed and synthesized in order to search for novel antihpertensive agents.The chemical structures of all the new compounds were identified by elemental analysis,IR,MS and 1HNMR. Preliminary pharmacological results in vitro & in vivo showed that all the compounds possessed vasodilatory and hypotensive activity in different degres.Among these compeunds,PC 08 was the most potent one.The detailed cardiovascular pharmacologital effecls are being further evaluated.

从吡啶基硫脲类化合物衍生、开发的Pinacidil是钾通道启开剂的代表药物之一。为寻找具钾通道启开作用的新型抗高血压药物,本文以Pinacidil类药物构效关系为依据,设计并合成了其4个硫脲(TC01~TC04)及8个氰胍类似物(PC01~PC08)。所有新化合物的结构均由元素分析,IR,MS和1 ̄HNMR证实。初步体内外药理试验表明:所合成的化合物均有不同程度的血管扩张及降压活性,其中以化合物PC08的作用最强。

The immune associated(Ia)antigen expression(IAAE) of macrophage is one of the important indicators of the specific immunity in the body.In this paper,mice of Yang Deficiency model was made by injecting corticosterone in the hind legs of mice to inhibit the function of hypothalamus -pituitary-adrenal axis.Authors observed the changes of IAAE in model mice and the effect of Aconitine on it.The results indicated that:(1)In model mice,the IFN-γ induced IAAE of peritoneal macrophages was inhibited.The difference...

The immune associated(Ia)antigen expression(IAAE) of macrophage is one of the important indicators of the specific immunity in the body.In this paper,mice of Yang Deficiency model was made by injecting corticosterone in the hind legs of mice to inhibit the function of hypothalamus -pituitary-adrenal axis.Authors observed the changes of IAAE in model mice and the effect of Aconitine on it.The results indicated that:(1)In model mice,the IFN-γ induced IAAE of peritoneal macrophages was inhibited.The difference of IAAE between the model and the normal mice was significant(P<0.01).(2)Aconitine could significantly increase the IAAE of model mice(P<0.01).These data implied that the immuno-suppression in the model mice of Yang Deficiency might be due to the lowered IAAE of macrophages under this condition.The promoting effects of Aconitine on IAAE enhanced the antigen presenting ability of macrophages and the immune response of the model mice.It might be related to the therapeutic mechanism of Aconitine on Yang Deficiency Syndrome.

巨噬细胞Ia抗原表达是衡量机体特异性免疫功能强弱的重要指标之一。本研究观察了皮质酮后腿肌肉注射复制的小鼠下丘脑─垂体─肾上腺轴抑制的“阳虚”动物模型腹腔巨噬细胞表面Ia抗原表达的改变,及温阳代表药物附子的主要成分乌头碱对其的作用。结果表明:阳虚动物腹腔巨噬细胞对γ-干扰素(IFN-γ)诱导的Ia表达活性较正常对照组降低(P<0.01);乌头碱则能明显提高阳虚模型小鼠巨噬细胞Ia抗原表达的水平(P<0.01)。提示阳虚证免疫功能低下的机理,可能与阳虚状态时巨噬细胞提交抗原能力降低有关;乌头碱增强巨噬细胞表面Ia抗原表达,提高其提交抗原能力,从而促进免疫应答反应,可能是附子提高免疫功能、治疗阳虚证的作用机理之一。

The effect of aconitine on the content of corticotropin-Releasing-Hormone (CRH) in the hypothalamus of the normal rat injected with aconitine intraperitoneally was studied by means of radioimmunoassay (RIA).Aconitine is the main effective component of Radix Aconiti Carmichaeli Praeparata, the representative traditional Chinese herbal medicine of Warm-Supplementing Kidney-Yang (WSKY). Results showed that the content of hypothalamic CRH menifested a dosede-pendent increase after 7 days intraperitoneal injection...

The effect of aconitine on the content of corticotropin-Releasing-Hormone (CRH) in the hypothalamus of the normal rat injected with aconitine intraperitoneally was studied by means of radioimmunoassay (RIA).Aconitine is the main effective component of Radix Aconiti Carmichaeli Praeparata, the representative traditional Chinese herbal medicine of Warm-Supplementing Kidney-Yang (WSKY). Results showed that the content of hypothalamic CRH menifested a dosede-pendent increase after 7 days intraperitoneal injection of aconitine (1μg/kg, 3μg/kg and 10μg/kg).The CRH neurons in the paraventricular nucleus of hypothalamus and the neural fibers of median eminence also demonstrated increases in number and enrichment in gray tone as observed by immunohistochemical method of ABC. These results suggested that one of the possible mechanism of the WSKY drugs in improving the HPA axis might be exciting the hypothalamic CRH neurons.

在建立促肾上腺皮质激素释放激素(CRH)放射免疫分析法的基础上,观察温补肾阳代表药物附子的重要有效成分乌头碱对正常大鼠下丘脑CRH含量的影响。结果表明:正常大鼠在腹腔注射乌头碱(1μg/kg,3μg/kg,10μg/kg)7天后,下丘脑CRH含量呈剂量依赖性增高,免疫组化法亦见:下丘脑室旁核CRH神经细胞及正中隆起神经纤维较对照组明显增多增深。提示温补肾阳药物改善下丘脑-垂体-肾上腺轴的可能机理之一是通过兴奋下丘脑CRH神经细胞。

 
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