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下游靶
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  downstream target
     p21waf1is the downstream target gene of Smad4while DPC4and p16may synergis tically play a role in the developmen t of pancreatic carcinoma.
     p21waf1是Smad4调控的下游靶基因,而DPC4和p16基因在胰腺癌的发生中可能有协同作用。
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     Regulation of Downstream Target Genes of Transcription Factor Oct-4 and Its Relationship with Toti/pluripotency of Embryonic Development
     转录因子Oct-4调控下游靶基因及其与胚胎发育全能/多能性的关系
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     This article highlights research progresses of molecular mechanism of P53 in the role of the drug resistance with respect to the homeostasis and the activation of downstream target genes of P53 as well as the interactions of P53 with other molecules/genes.
     现从P53自身稳定性、下游靶基因的活化及P53与其他分子/基因相互作用3个方面对其在肿瘤耐药性分子机制研究的进展进行简要阐述。
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     CONCLUSIONS: The constitutive or hypoxia-induced expression of HIF-1α in EPCs is sufficient to affect the expression of downstream target genes. SiRNA targeting HIF-1α could inhibit the expression of the genes which promote neovascularization, and suppress the differentiation of EPC to EC.
     结论:固有的或低氧诱导的HIF鄄1α表达足以影响下游靶基因表达,siRNA能抑制促血管新生的靶基因,抑制EPCs向EC分化。
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     Most reactions of plant cells to abiotic and biotic stimuli were thought to be related with Ca 2+ signal transduction. Calmodulin and calmodulin-related proteins were downstream target proteins of Ca 2+ signal transduction.
     植物对一系列生物和非生物刺激所产生的反应都与细胞内Ca2+信号转导有关,而钙调素、钙调素相关蛋白则是Ca2+信号转导的下游靶蛋白。
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  “下游靶”译为未确定词的双语例句
     HIF-1α and its controlled target gene VEGF were markedly induced by HIF-1α vector (P<0.05).
     其下游靶基因VEGF在HIF-1α过表达组表达上调(P<0.05);
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     Rho-associated coiled-coil kinase (ROCK) and Dial, as the downstream targets of Rho, induce the formation of the stress fibres.
     Rho通过活化其下游靶分子促进应力纤维的形成,其中Rho-associated coiled-coil kinase(ROCK)和Dial在该过程中起关键作用;
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     To explore the relationship between inactivation of TGF-β signaling pathway and acute leukemia, the expressions of TGF-β1, TβRⅡ and c-myc in the bone marrow mononuclear cells were detected by S-P immunocytochemical staining.
     为了探讨转化生长因子β(transforming growth factor-beta,TGF-β)信号转导途径失活与急性白血病的关系,用S-P免疫细胞化学法检测急性白血病患者骨髓单个核细胞中TGF-β1及其Ⅱ型受体(TβRⅡ)和信号下游靶基因蛋白c-myc的表达。
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     To regulate targeting positions of the signal pathway such as PI3K and Akt/PKB or upstream and downstream effectors can probably prevent and treat type 2 diabetes mellitus.
     调节该通路PI3K、Akt/PKB及其上下游靶位点,可能为2型糖尿病的防治提供广阔前景。
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     Suppression of LRP16 expression in MCF-7 cells attenuated the stimulative responsiveness of estrogen-induced genes(E2F1,RARa,c-fos,cyclin D1,and MTA3)to E2,but had no effects on the expression of cathepsin D.
     同时也降低了ERα下游靶基因对E2的反应性上调效应,其中包括E2F1、维甲酸受体α(RARα)、c-fos、cyclin D1和MTA3,但对cathepsin D的表达无影响。
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  相似匹配句对
     Cloning and Characterization of the Novel Target Genes of the Transeriptor c-MYC
     转录因子c-MYC下游基因的克隆及功能研究
     (7) Target sign;
     (7)征;
短句来源
     Genetic engineering downstream procession
     基因工程的下游技术
短句来源
     Transparent conductive film and target material
     透明导电膜及
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     Z is the difference between upsteam and downstream water surface;
     Z为上下游水位差;
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  downstream target
This review elucidates the role of β1-integrins in mediating signal transduction between muscarinic receptors and coupled downstream target proteins such as ion channels.
      
Additionally, a portion of a-adrenergic, serotonergic, and endothelin-1-induced contraction is partially mediated by the calcium-independent activation of the small G-protein RhoA and of a downstream target, Rho-kinase.
      
Improving islet transplantation by gene delivery of hepatocyte growth factor (HGF) and its downstream target, protein kinase B (
      
Cyclin E, a major downstream target of cyclin D1, decreased concomitantly to the reduction in cyclin D1/CDK4-dependent kinase activity.
      
A major BRCA1 downstream target gene is the DNA damage-responsive gene GADD45.
      
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Notch proteins are involved in cell fate selection throughout development. Signalling through the transmembrane receptor Notch is triggered by ligand binding, which induces the proteolytic cleavage of the Notch protein. This cleavage generates an intracellular fragment of the Notch protein (Notch ICD), which translocates into the nucleus and modifies transcription of target genes through its association with the CSL familily of DNA binding protein (where CSL stands for CBF1, Su (H), Lag 1). Notch activity...

Notch proteins are involved in cell fate selection throughout development. Signalling through the transmembrane receptor Notch is triggered by ligand binding, which induces the proteolytic cleavage of the Notch protein. This cleavage generates an intracellular fragment of the Notch protein (Notch ICD), which translocates into the nucleus and modifies transcription of target genes through its association with the CSL familily of DNA binding protein (where CSL stands for CBF1, Su (H), Lag 1). Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis. To obtain recombinant rat NICD, a long template and high fidelity PCR was used to clone NICD (1744V 2530K) DNA fragment from rat brain cDNA library. The cloned NICD fragment was confirmed by sequencing and then subcloned into glutathione S transferase (GST) fusion protein expression vector pGEX KG. The GST NICD fusion proteins were expressed in E.coli JM109 after inducing by IPTG. The fusion proteins were purified by affinity chromatography on glutathione Sepharose 4B.

Notch 1信号途径参与决定细胞命运 ,其水解后产生的活性片段———胞质段 (Notch 1intracellularcytoplasmicdomain ,NICD)能被转运进核 ,激活下游靶基因的表达 .Notch 1参与细胞的增殖、分化、程序性死亡、发育过程中的形态发生和器官形成等许多重要过程 .为了获得重组的NICD ,以大鼠脑cDNA文库为模板 ,用PCR方法扩增出编码NICD的基因片段 ,克隆至谷胱甘肽 S 转移酶 (GST)融合表达载体pGEX KG中 ,并在大肠杆菌中获得较高水平的表达 .表达的融合蛋白GST NICD分子质量约为 12 0ku左右 ,以包涵体和可溶性两种形式存在 ,易于亲合层析纯化 .为制备抗体和进一步的功能研究奠定了基础 .

Objective To investigate exogenous ceramide induced apoptosis in colon carcinoma LoVo cells.Methods LoVo cells were pretreated for 3 h with or without the presence of phorbol 12 myristate 13 acetate (PMA), a potent protein kinase C (PKC) stimulator, later treated with C 2 , C 6 ceramide or C 2 dihydroceramide, and then passed through gel electrophoresis, Heochest 33342 fluorescence staining and flow cytometry with Annexin V/PI staining. The treated LoVo cells were observed for biochemical and morphologic...

Objective To investigate exogenous ceramide induced apoptosis in colon carcinoma LoVo cells.Methods LoVo cells were pretreated for 3 h with or without the presence of phorbol 12 myristate 13 acetate (PMA), a potent protein kinase C (PKC) stimulator, later treated with C 2 , C 6 ceramide or C 2 dihydroceramide, and then passed through gel electrophoresis, Heochest 33342 fluorescence staining and flow cytometry with Annexin V/PI staining. The treated LoVo cells were observed for biochemical and morphologic changes. Results Treatment with C 2 or C 6 ceramide in the range of indicated concentrations (10~25 μmol/L) for 12 to 24 hours resulted in apoptosis in LoVo cells, whereas C 2 dihydroceramide, which is similar to C 2 ceramide in configuration but lacks the trans double bond at C 4-C 5 of the sphingoid base backbone, did not induce the apoptosis at the same or even higher concentrations, indicating that the ceramide induced apoptosis was stereospecific. Moreover, the exogenous ceramide induced apoptosis in LoVo cells was inhibited in part by PMA. Conclusion Ceramide takes part in the process of apoptotic signal transduction in LoVo cells. PKC may be one of downstream target molecules acted by ceramide

目的 探讨外源性神经酰胺诱导大肠癌 L o Vo细胞凋亡的作用。方法 在有或无蛋白激酶 C激活剂 PMA预处理 L o Vo细胞 3 h的条件下 ,分别用 C2 -和 C6 -神经酰胺以及 C2 -二羟基神经酰胺处理指数生长期的 L o Vo细胞 ,用琼脂糖凝胶电泳 ,Heochest33342荧光染色和 Annexin V/PI双染色流式细胞仪观测 L o Vo细胞的形态学和生化特征方面的改变。结果  C2 -和 C6 -神经酰胺在一定的浓度范围内(10 - 2 5μmol/L )处理 L o Vo细胞 12~ 2 4h可诱导其凋亡 ,但浓度超过 5 0μmol/L则引起 L o Vo细胞的坏死增多 ,而与神经酰胺结构相似但缺乏鞘脂碱基骨架 C4- C5 反式双键的C2 -二羟基神经酰胺在相同甚至更大的剂量时都不引起L o Vo细胞的凋亡 ;PMA对 C2 -和 C6 -神经酰胺诱导的 L o Vo细胞凋亡具有抑制作用。结论 神经酰胺参与 L o Vo细胞凋亡的信号传导过程 ,并具有结构特异性 ;蛋白激酶 C可能是神经酰胺调控细胞凋亡的下游靶分子之一

The Wnt/Wingless signaling pathway plays a critical role in both embroynic development and tumorigenesis. Deregulation of the Wilt signaling by APC and β-catenin mutation results in β-catenin accumulation and transcriptional activation of specific target genes such as c-myc and cyclin D1, contributing significantly to neoplastic transformation and carcinogenesis, and are particularly important in colon cancer.

W nt/Wingless途径是调控细胞生长增殖的关键途径,在胚胎发育和肿瘤发生中起着重要作用。 由于肿瘤抑制基因APC失活突变或原癌基因β-catenin激活突变等因素引起的该途径的异常激活可以 启动下游靶基因c-myc和cyclin D1,致使细胞恶性转化,发生肿瘤;尤其是结肠癌。本文对Wnt- APC-β-catenin-TCF/LEF-c-myc/cyclin D1信号途径的最新研究进展作一综述。

 
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