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     The results indicate that the quantity Z of R_1O~+ is decreased by the isomerization of R_1 and increased by the nonbranching of R_1;
     结果表明,R_1O~((?) +)的Z值为R_1的异构化所降低而为非异构化的直链R_1烷基所增加;
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     RESULTS: Differential value of lowing total cholesterol (TC), triglyceride (TG), and low_density lipoprotein cholesterol ( LDL _ Ch ) in two groups all showed significant reductions ( P < 0.05), which had no significant difference between the 2 groups (P>0.05).
     结果 :国产与进口洛伐他汀治疗前后所降低总胆固醇(TC)、三酰甘油 (TG)和低密度脂蛋白胆固醇 (LDL_Ch)差异均有显著意义 (P <0 .0 5 ) ,但 2组间比较差异无显著意义 (P >0 .0 5 )。
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     Results showed that the maximal quantum efficiency (Fv/Fm) and the effective quantum efficiency (φPSⅡ) of photosystem Ⅱ (PS Ⅱ) were reduced by exogenous NO under illumination (150 μmol·m-2·s-1, 25℃). This influence was related not only to the concentration of sodium nitroprusside (SNP, a NO donor) solution, but also to the active duration of NO on leaf tissue.
     在光照条件下(150 μmol·m-2·s-1,25℃),光系统Ⅱ(PS Ⅱ)的最大量子效率(Fv/Fm)和有效量子效率(φPSⅡ)均被SNP所降低,这种影响不仅与SNP的浓度有关,也与其作用时间有关。
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     In MI group, serum CPK and LDH activities were remarkably higher than those in sham group(P<0.05, P<0.01). The increased serum CPK and LDH activities induced by ligation of the coronary artery were significantly reduced by pretreatment with SXM and SXBXW(P<0.05, P< 0.01).
     心肌梗死组大鼠的血清CPK和LDH活力均明显高于假手术组(P<0.05,P<0.01),而升高的酶活力可以被预先给予麝香合剂或麝香保心丸所降低(P<0.05P<0.01)。
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     In model group,serum AST,CK and LDH activities were remarkably higher than those in sham group (P < 0.01 ).
     模型组大鼠的血清AST,CK,LDH活力明显高于假手术组(P<0.01),而升高的酶活力可以被预先给予各给药剂量的皂荚皂苷所降低(P<0.05,P<0.01);
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     the blood sugar decreased.
     血糖降低
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     The ratio of renal flow volume to cardiac output was also decreased.
     心输出量降低 ;
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     c.
     s占c-F。
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     The proportion of nitrogen excretion decreased with increasing body weight.
     随体重的增加 ,排泄氮占比例降低
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     The plasma insulin level decreased whichcould be prevented by AL.
     血胰岛素降低并可被AL预防;
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Cycloheximide-Induced Decrease in Frost Resistance of Winter Wheat Is Mediated by Inhibited Adaptive Rearrangement of the Cell a
      
Choline succinate administration significantly improved memory and learning in ischemic rats and prevented the ischemia-induced decrease in the cerebral level of N-acetylaspartate.
      
Subsequent addition of micromolar concentrations of thyroxin decreased the rate of uncoupler-stimulated respiration and partially reversed uncoupler-induced decrease of membrane potential (DY).
      
We suggest that the ABA-induced decrease in the levels of proteins and MTs occurs at the initial stages of plant cold acclimation (3°C, 2-3 days).
      
(2003) FASEB, 17, 1585-1591)and/or of efflux of PPO anions with involvement of the GDP-sensitive ADP/ATP antiporter; 3) PPO can potentiate the oleate-induced decrease in Δψ due to inhibition of succinate oxidation.
      
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Injectio Salvia miltiorrhizae Composita is composed of 1:1 extracts of Salvia miltiorrhiza and Dalbergia odorifera.The intraperitoneal injections (ip) of 20 g/kg of this composita prolonged significantly the survival time of the mice under normobaric hypoxia, and this protective effect lasted at least 3 hours. The ip of 10~20 g/kg resulted in a prolongation of survival time and an elevation of survival % of the mice under hypobaric hypoxia. The ip of 5 g/kg also lengthened notably the survival time of rats....

Injectio Salvia miltiorrhizae Composita is composed of 1:1 extracts of Salvia miltiorrhiza and Dalbergia odorifera.The intraperitoneal injections (ip) of 20 g/kg of this composita prolonged significantly the survival time of the mice under normobaric hypoxia, and this protective effect lasted at least 3 hours. The ip of 10~20 g/kg resulted in a prolongation of survival time and an elevation of survival % of the mice under hypobaric hypoxia. The ip of 5 g/kg also lengthened notably the survival time of rats. Guanethidine, in both initial and late phases of its action, lowered the tolerance towards the hypobaric hypoxia of mice, whereas this composita could restore the tolerance only in the late phase of guanethidine action. After ip 30 g/kg in mice, the O_2 consumption rate was slowed down in normobaric hypoxia, and the survival time was prolonged remarkably which decreased the residual O_2 content more than the control mice at the time of death. It is suggested that this composita might improve the O_2 utilization during hypoxia.In the concentration of 10 mg/ml this composita enhanced markedly the coronary flow on isolated guinea pig hearts, but not on fibrillating hearts. When this coinposita was given intravenously (ⅳ) 4 g/kg, the % of myocardial uptake of ~(86)Rb was not raised in rats. This indicates that the myocardial blood flow was not augmented.In anesthetized open-chest dogs, the ⅳ of 1 g/kg produced no marked alteration of coronary blood flow and coronary resistance. The ⅳ injection of 0.75g/kg did not yield remarkable influence on cardiac hemodynamic results either.

腹腔注射复方丹参20 g/kg,可显著延长小鼠在常压缺氧情况下的存活时间,作用持续时间达3小时以上。腹腔注射10~20 g/kg,可显著延长小鼠在低压缺氧条件下的存活时间和提高存活率。腹腔注射5 g/kg,也能显著延长大鼠在低压缺氧的存活时间。胍乙啶的初和晚时相,均可降低小鼠对低压缺氧的耐受力,而复方丹参只能提高晚时相所降低的耐缺氧能力。腹腔注射复方丹参30 g/kg,显著延长常压缺氧的存活时间和减慢小鼠氧耗速率,死亡时余存氧含量亦较对照组显著减低,表明复方丹参可能是提高小鼠在低氧状态下对氧的利用。 复方丹参浓度为10 mg/ml,显著增加离体豚鼠心脏的冠脉流量,但不增加颤动心脏的冠脉流量。静注复方丹参4g/kg,不增加大鼠心肌摄取~(86)Rb率,表明不增加心肌血流量。麻醉开胸狗,静注复方丹参1 g/kg,对冠脉流量和冠脉阻力无明显作用。麻醉狗静注复方丹参0.75 g/kg,对心脏血流动力作用也无明显影响。

The effect of PAS-Na treatment was investigated in rats after the daily ip with MnCl2 ?4H2O (15mg/kg/day ) for a period of 12 weeks. The contents of dopamine ( DA ) , norepinephrine ( NE ) , serotonin ( 5-HT ) and 5-hydroxyindoleacetic acid(5-HIAA ) were measured in several brain regions ( cerebral cortex, striatum, hypthalamus and "rest of the brain" by fluorospectrophotometry. The results showed that a significant decrease in the concentration of DA in striatum and cerebral cortex, 5-HT in brain, and 5-HIAA...

The effect of PAS-Na treatment was investigated in rats after the daily ip with MnCl2 ?4H2O (15mg/kg/day ) for a period of 12 weeks. The contents of dopamine ( DA ) , norepinephrine ( NE ) , serotonin ( 5-HT ) and 5-hydroxyindoleacetic acid(5-HIAA ) were measured in several brain regions ( cerebral cortex, striatum, hypthalamus and "rest of the brain" by fluorospectrophotometry. The results showed that a significant decrease in the concentration of DA in striatum and cerebral cortex, 5-HT in brain, and 5-HIAA in striatum of rats after manganese exposure was produced, NE significantly increased in striatum and hypthalamus of the same group of animals. It is of interest to note that treatment with PAS-Na resulted in an elevation in the levels of DA, NE, 5-HT and 5-HIAA in the most brain regions of the rats exposed to manganese. The increased levels of 5-HT and 5-HIAA are mostly lower than that of NE and DA, suggesting the serotonergic neurons to be less sensitive to PAS-Na effects than catecholaminergic ones.

本文报道了对氨基水杨酸钠(PAS-Na)对氯化锰腹腔注射染毒大鼠脑单胺递质水平的影响。PAS-Na能使锰染毒所降低了的脑多巴胺(DA)水平逆转;锰使脑去甲肾上腺素(NE)含量增加,染毒后以PAS-Na治疗则使之进一步升高;锰染毒和染毒后治疗组的5-羟色胺(5-HT)及5-羟吲哚醋酸(5-HIAA)的变化与DA相似,但PAS-Na使5-HT、5-HIAA水平升高的幅度大都较NE和DA的要小,提示5-HT能神经元对PAS-Na治疗作用的敏感性低于儿茶酚胺(CA)能神经元。

Four derivatives [(R_1O)(R_2S)P=O(SH)] of dithiophonic acid were determinated and interpretated. They are (Ⅰ) R_1=R_2=n-C_3H_7; (Ⅱ): R_1=-CH_3, R_2=-CH(CH_3)_2; (Ⅲ): R_1=-CH_3, R_2=-C_2H_5; (Ⅳ): R_1=n-C_3H_7, R_2=-CH_3.A variety of α cleavages to P=O double bond have been studied. The quantity Z(Z=R_1O~+ abundance/M~- abundance) of fragments R_1O~+ for different R_1 produced by α cleavages is compared with each other. The results indicate that the quantity Z of R_1O~+ is decreased by the isomerization of R_1...

Four derivatives [(R_1O)(R_2S)P=O(SH)] of dithiophonic acid were determinated and interpretated. They are (Ⅰ) R_1=R_2=n-C_3H_7; (Ⅱ): R_1=-CH_3, R_2=-CH(CH_3)_2; (Ⅲ): R_1=-CH_3, R_2=-C_2H_5; (Ⅳ): R_1=n-C_3H_7, R_2=-CH_3.A variety of α cleavages to P=O double bond have been studied. The quantity Z(Z=R_1O~+ abundance/M~- abundance) of fragments R_1O~+ for different R_1 produced by α cleavages is compared with each other. The results indicate that the quantity Z of R_1O~+ is decreased by the isomerization of R_1 and increased by the nonbranching of R_1; In the case of R_2S~+ , the quantity Z (Z=R_2S~+ abundance/M~+ abundance) of R_2S~- is increased by smallar R_2 and decreased by bigger R_2.

测定并解析了四个O-烃基-S-烃基二硫代磷酸衍生物[(R_1O)(R_2S)P=O(SH)]的EI谱。这些衍生物是(Ⅰ)R_1=R_2=n—C_3H_7;(Ⅱ)R_1=—CH_3,R_2=—CH(CH_3)_2;(Ⅲ)R_1=—CH_3,R_2=—C_2H_5;(Ⅳ)R_2=n—C_3H_7;R_2=—CH_3。探讨了对于P=O双键的多种α开裂。比较了R_1不同时α开裂碎片R_1O~((?)+)的Z值(Z=R_1O~((?)+)丰度/M~+丰度)。结果表明,R_1O~((?)+)的Z值为R_1的异构化所降低而为非异构化的直链R_1烷基所增加;在R_2S~((?)+)的情况下,R_2S~((?)+)的Z值(Z=R_2S~((?)+)丰度/M~+丰度)为较小的烷基R_2所增加,为较大的烷基R_2基团所减小。

 
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