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    It has been shown previously that caffeine sensitive Ca 2+ stores gated by ryanodine receptors (RyRs) and the mechanism of Ca 2+ induced Ca 2+ release (CICR) exist in the soma of carp retinal ON type bipolar cells [1] .
    以前结果表明 ,ryanodine受体 (ryanodinereceptors ,RyRs)门控的咖啡因敏感的钙库和钙引钙释放(Ca2 + inducedCa2 +release ,CICR)机制存在于鲫鱼视网膜ON型双极细胞的胞体中[1] 。
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    Immunocytochemical study of both vertical section and dissociated cells of the retina indicates that RyRs were mainly localized in the soma of ON type bipolar cells.
    视网膜纵切和分离细胞的免疫细胞化学研究显示 ,RyRs主要位于ON型双极细胞的胞体中。
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    Taken together, it is indicated that RyR gated caffeine sensitive Ca 2+ stores and CICR are absent in the terminal of carp retinal ON type bipolar cells.
    这些结果表明 ,在鲫鱼视网膜ON型双极细胞的轴突末梢中不存在RyRs门控的咖啡因敏感的钙库和CICR机制
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  “on型”译为未确定词的双语例句
    Absence of ryanodine receptor gated Ca~(2+) stores in the terminal of carp retinal ON-type bipolar cells
    鲫鱼视网膜ON型双极细胞的轴突末梢中不存在ryanodine受体门控的钙库(英文)
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Bayesian prediction for the two-parameter exponential distribution based on type II doubly censoring
      
Prediction intervals are derived for unobserved lifetimes in one-sample prediction and two-sample prediction based on type II doubly censored samples.
      
This review focuses on type IIF and IIE REs, which require simultaneous interaction with two nucleotide sequences for efficient DNA cleavage.
      
The formation of the indicated signals in structures of mid-infrared-range lasers of a new type based on type-II GaInAsSb/InGaAsSb heterostructures as well as in the conventional InAsSb/InAsSbP heterostructures is analyzed.
      
Photodiodes for a 1.5-4.8 μm spectral range based on type-II GaSb/InGaAsSb heterostructures
      
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Objective: To prepare monoclonal antibodies (McAb) against human GPA for studying human erythrocyte glycophorin A(GPA) gene mutation and glycosylation variation. Methods: Hybridizing Sp2/0 cells with the spleen cells from BALB/c mice immunized with O,MM type human erythrocytes and purified M GPA, O,NN type human erythrocytes and purified N GPA respectively, follolvel by selecting by hemagglutination of untreated and enzyme treated human erythrocytes and identifing by indirect immuno fluorescence microscopy,...

Objective: To prepare monoclonal antibodies (McAb) against human GPA for studying human erythrocyte glycophorin A(GPA) gene mutation and glycosylation variation. Methods: Hybridizing Sp2/0 cells with the spleen cells from BALB/c mice immunized with O,MM type human erythrocytes and purified M GPA, O,NN type human erythrocytes and purified N GPA respectively, follolvel by selecting by hemagglutination of untreated and enzyme treated human erythrocytes and identifing by indirect immuno fluorescence microscopy, ELISA and Western blotting, 5 mouse McAbs have been obtained. Results: The 5 McAbs are directed to GPA NH 2 terminal 1-39 peptide, and are sialic acids dependent except 2E9. Both 2E9 Ig(G1,λ) and 9E9 Ig(G3,κ) are antibodies to M,N type GPA, the epitope of 2E9 is located at M,N GPA homologous 6-39 residues and that of 9E9 is on M,N GPA 1-26 residues; The determinant of the other 3, i.e, 3C3 Ig(G1,κ),5F9 Ig (G3,κ)and 6A8 Ig(G3,λ), are located on N GPA1-6 peptide. 4 of the 5 McAbs don′t react to trypsin treated erythrocytes, 6A8 can agglutinate trypsin treated MM but not NN erythrocytes, suggesting that GPBs on the MM and NN cells may be different in some extent. Conclusion: These McAbs are valuable for studying GPA variation resulting from gene mutation and glycosylation variation.

目的:制备抗人红细胞膜血型糖蛋白A(GPA)的特异单克隆抗体,对研究GPA基因突变和GPA蛋白糖基化变异有重要意义。方法:分别用OM和纯化M-GPA蛋白以及ON型红细胞和纯化N-GPA蛋白免疫BALB/c小鼠,取脾细胞与小鼠骨髓瘤细胞Sp2/0融合,经正常和酶处理人细胞凝集筛选,间接免疫荧光,酶联免疫分析及蛋白质印迹鉴定,制备了鼠抗人GPA的单克隆抗体。结果:获得抗GPA蛋白1~39位肽段及相关糖链的5株单抗,除2E9以外均为糖链依赖型。其中抗M,N-GPA单抗2株:2E9Ig(G1,λ)和9E9Ig(G3,κ);2E9抗M,N-GPA6-39位同源肽段,9E9抗M,N-GPA1~26位肽段。N-GPA单抗3株:3C3Ig(G1,κ),5F9Ig(G3,κ)和6A8Ig(G3,λ),均为抗N-GPA1~6位肽段抗体。4株单抗与胰蛋白酶处理的红细胞不能反应,6A8使胰蛋白酶处理的M型红细胞凝集而不能凝集胰蛋白酶处理的N型红细胞,推测M和N型红细胞的GPB蛋白存在某种差异。结论:这些抗体对研究GPA基因突变和蛋白糖基化变异有应用价值

It has been shown previously that caffeine sensitive Ca 2+ stores gated by ryanodine receptors (RyRs) and the mechanism of Ca 2+ induced Ca 2+ release (CICR) exist in the soma of carp retinal ON type bipolar cells [1] . Using immunocytochemistry of RyRs and intracellular Ca 2+ measurement, we further investigated whether RyR gated Ca 2+ stores are present in the terminal of these cells. Immunocytochemical study of both vertical section and dissociated cells of the retina indicates...

It has been shown previously that caffeine sensitive Ca 2+ stores gated by ryanodine receptors (RyRs) and the mechanism of Ca 2+ induced Ca 2+ release (CICR) exist in the soma of carp retinal ON type bipolar cells [1] . Using immunocytochemistry of RyRs and intracellular Ca 2+ measurement, we further investigated whether RyR gated Ca 2+ stores are present in the terminal of these cells. Immunocytochemical study of both vertical section and dissociated cells of the retina indicates that RyRs were mainly localized in the soma of ON type bipolar cells. Caffeine up to 40 mmol/L could not induce Ca 2+ signal in the terminal. After resting [Ca 2+ ] i was slightly increased by raising external K + to 10 mmol/L, no Ca 2+ signal was induced by caffeine in the terminal. In the presence of forskolin or dopamine, by which intracellular cAMP and in turn cAMP dependent phosphorylation are enhanced, caffeine also failed to bring Ca 2+ signal in the terminal. In addition, 50 μmol/L ryanodine did not show any effect on Ca 2+ signal evoked by 65 mmol/L K + for 1 min or 2 min in the terminal. Taken together, it is indicated that RyR gated caffeine sensitive Ca 2+ stores and CICR are absent in the terminal of carp retinal ON type bipolar cells.

以前结果表明 ,ryanodine受体 (ryanodinereceptors ,RyRs)门控的咖啡因敏感的钙库和钙引钙释放(Ca2 + inducedCa2 +release ,CICR)机制存在于鲫鱼视网膜ON型双极细胞的胞体中[1] 。采用RyRs的免疫细胞化学方法和细胞内钙测量技术 ,我们进一步研究了RyRs门控的钙库是否存在于这些细胞的轴突末梢中。视网膜纵切和分离细胞的免疫细胞化学研究显示 ,RyRs主要位于ON型双极细胞的胞体中。咖啡因浓度升至 4 0mmol/L在轴突末梢不能诱导钙信号。在细胞外K+浓度升至 10mmol/L引起静息 [Ca2 +]i 轻微升高后 ,咖啡因在轴突末梢也不能诱导钙信号。在forskolin或多巴胺引起细胞内cAMP浓度升高 ,进而cAMP依赖的磷酸化增强后 ,咖啡因在轴突末梢仍不能诱导钙信号。此外 ,50 μmol/Lryanodine对 65mmol/LK+作用 1min或 2min诱导的轴突末梢的钙信号没有产生任何效应。这些结果表明 ,在鲫鱼视网膜ON型双极细胞的轴突末梢中不存在RyRs门控的咖啡因敏感的钙库和CICR机制

 
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