助手标题  
全文文献 工具书 数字 学术定义 翻译助手 学术趋势 更多
查询帮助
意见反馈
   作用 在 肿瘤学 分类中 的翻译结果: 查询用时:0.061秒
图标索引 在分类学科中查询
所有学科
肿瘤学
中药学
体育
高等教育
药学
企业经济
教育理论与教育管理
图书情报与数字图书馆
外国语言文字
更多类别查询

图标索引 历史查询
 

作用
    很抱歉,暂未找到该词条在当前类别下的译词。您可以查看在所有学科下的译词。
相关语句
  “作用”译为未确定词的双语例句
    Experimental Study on SH2 Domain Containing Protein Tyrosine Phosphatase SHP-1 and SHP-2 in γ-ray Irradiation Induced Tumor
    SHP-1和SHP-2在γ射线诱发的恶性肿瘤中作用的实验研究
短句来源
    The Experiment Study on Chlorophyllin Preventing Colorectal Tumors Induced by DMH in Mice and Inhibiting HT29 Cells in Vitro
    叶绿酸铜钠预防化学诱导大肠肿瘤的实验研究及对HT29肠癌细胞的体外抑制作用研究
短句来源
    Study on hMLH1、p16、FHIT Gene in NSCLC
    hMLH1、p16、FHIT基因在非小细胞肺癌发病机制中作用的研究
短句来源
    Anti-tumor Immunotherapy with Anti-HER2 Antibody/Flt3L Bispecific Fusion Protein
    抗HER2抗体/Flt3L双功能融合蛋白的抗肿瘤作用机理研究
短句来源
    Adoptive Tumor Immunotherapy Mediated by T Cells Expressing Chimeric T Cell Receptor
    表达嵌合T细胞受体的T淋巴细胞介导的肿瘤过继性免疫治疗作用机理研究
短句来源
更多       
查询“作用”译词为用户自定义的双语例句

    我想查看译文中含有:的双语例句
例句
没有找到相关例句


This paper reports the results of the clinical use of Corydalis B as an analgesic in 72 patients with various forms of pain. In 64 cases the drug was used in a single dose, usually of 75 mg. by oral route, while in the other 8 cases repeated doses were given orally over a period of 3 to 21 days. The pain was completely abolished or definitely improved in 50 cases (78.1%) of the former group and in all 8 cases of the latter group. The analgesic effect appeared to be most marked in medical cases with dull pain...

This paper reports the results of the clinical use of Corydalis B as an analgesic in 72 patients with various forms of pain. In 64 cases the drug was used in a single dose, usually of 75 mg. by oral route, while in the other 8 cases repeated doses were given orally over a period of 3 to 21 days. The pain was completely abolished or definitely improved in 50 cases (78.1%) of the former group and in all 8 cases of the latter group. The analgesic effect appeared to be most marked in medical cases with dull pain in the chest or abdomen, as in cases of peptic ulcer and lobar pneumonia. Drowsiness was found as a side-effect in 28% of the cases after a single dose of the drug and in 6 of the 8 cases treated with repeated doses. In no case was any serious toxic action noted. According to the preliminary Observations herein reported, further clinical trial with the use of Corydalis B as an analgesic agent seems warranted.

本文报告72例试用延胡索素乙硫酸盐作为鎮痛剂的临床观察,其中64例为单剂用药,主要为一次口服75毫克,另8例为长期口服。单剂用药64例中完全止痛及疼痛减轻者共50例,占78.1%,长期服药8例均有效,鎮痛作用在内科胸腹部鈍痛病例较著。用药后未見重要副作用,单剂用药者28%发生嗜睡。长期用药的8例中6例有嗜睡,血与尿常規、大便次数、血压、心率等均无明显改变。据本文病例的初步临床应用结果,延胡索素乙对钝痛有一定的镇痛效果值,得进一步试用。

In the 3'-MeDAB induced liver tumour, it was found that the activities of glucoses-6-phosphate dehydrogenase, 6-phosphogluconic dehydrogenase and dipeptidases were higher than those in the normal liver, while the activities of glutamic dehydrogenase, glutaminase(phosphate-activated), ornithine carbamyl transferase, tryptophan pyrrolase, threonine dehydrase and tyrosine transaminase were lower or even absent.Changes in most enzyme activities were observed in the precancerous stage and the pattern of these changes...

In the 3'-MeDAB induced liver tumour, it was found that the activities of glucoses-6-phosphate dehydrogenase, 6-phosphogluconic dehydrogenase and dipeptidases were higher than those in the normal liver, while the activities of glutamic dehydrogenase, glutaminase(phosphate-activated), ornithine carbamyl transferase, tryptophan pyrrolase, threonine dehydrase and tyrosine transaminase were lower or even absent.Changes in most enzyme activities were observed in the precancerous stage and the pattern of these changes followed that in the liver tumour. Thus in the course of carcinogenesis, the activities of glucose-6-phosphate dehydrogenase, 6-phosphogluconic dehydrogenase and dipeptidase(glycylglycine as substrate)increased while those of glutamic dehydrogenase, glutaminase and ornithine carbamyl transferase decreased. However, there was no significant change in the activity of dipeptidase when DL-alanylglycine was used as substrate. Changes in activity of tryptophan pyrrolase and tyrosine transaminase were not pronounced as compared with those of the control. The activity of glutathione reductase in the liver tumour was similar to that of normal liver, but it increased from the 4th to 13th week of feeding of the carcinogen. Threonine dehydrase was remarkably influenced by the nutritive factor of the basal diet so that the effect of 3'-MeDAB on threonine dehydrase could not be observed during carcinogenesis.A comparative study has been made with 2-MeDAB, a non-carcinogenic substance. It had no apparent effect on the above enzymes except that it caused the activity of glutamic dehydrogenase to be higher than that of the control.Further experiments have shown that the specific activities of glutamic dehydrogenase and glutaminase in the mitochondria of liver tumour were lower than those of the control. In the precancerous liver the specific activity of glutaminase in the mitochondria was lower than that of the control, while there was no significant change in the case of glutamic dehydrogenase.From these results together with those from other laboratories a possible biochemical mechanism of the carcinogenesis induced by 3'-MeDAB was proposed(Fig. 12). It was suggested that the change in enzyme activity during carcinogenesis may possibly have resulted from the carcinogen being first metabolized in the liver, leading to a higher activity of the oxidative metabolism of glucose-6-phosphate and exhibiting influences on liver enzymes by the metabolites of 3'-MeDAB through different mechanisms. Consequently there produced an abnormal growth and differentiation of liver cell which became neoplastic with the formation of liver cancer, 2-MeDAB may be metabolized in a different way from that of 3'-MeDAB thus producing different effects on most enzyme activities. It is therefore evident that the specific effect of 3'-MeDAB on the liver enzymesmay be closely related to its property of carcinogenisity.

在3'-MeDAB誘发的肝癌組織中,G-6-PD、6-PGD、二肽酶的活性都較正常肝高,而另一些酶如GDH、GMA、OCT、TP、TD、TTA的活性則較正常肝低或甚至測不出来。大多数酶活性都在癌前期即有明显的变化,其变化情况多趋向于癌的特征,如肝癌組織中活性較高的酶,在引癌过程中其活性較对照組有升高趋势,如G-6-PD、6-PGD、二肽酶(以甘氨酰甘氨酸为底物);肝癌組織中活性降低的酶,在引癌过程中其活性有降低趋势,如GDH、GMA、OCT。但以丙氨酰甘氨酸为底物的二肽酶活性的变化則与对照組基本相似。癌前期TP及TTA活性較对照組都无明显差异。肝癌組織中GSSGR活性与正常肝相似,但在引癌过程中(4—13周)則有升高趋势。苏氨酸去水酶受基础食料中营养因素的影响較大,癌前期看不出3'-MeDAB对它的影响。非致癌物,2-MeDAB,除了使GDH活性升高外,对上述其他酶活性都无明显的影响。肝癌綫粒体內GMA和GDH比活性都較对照組及正常肝綫粒体为低。癌前期肝綫粒体GMA比活性較对照組显著降低,而GDH比活性則无明显改变。根据本实驗及其他实驗室結果,我們认为:3'-MeDAB所引起的肝脏酶活性变化,可能是由于它在肝...

在3'-MeDAB誘发的肝癌組織中,G-6-PD、6-PGD、二肽酶的活性都較正常肝高,而另一些酶如GDH、GMA、OCT、TP、TD、TTA的活性則較正常肝低或甚至測不出来。大多数酶活性都在癌前期即有明显的变化,其变化情况多趋向于癌的特征,如肝癌組織中活性較高的酶,在引癌过程中其活性較对照組有升高趋势,如G-6-PD、6-PGD、二肽酶(以甘氨酰甘氨酸为底物);肝癌組織中活性降低的酶,在引癌过程中其活性有降低趋势,如GDH、GMA、OCT。但以丙氨酰甘氨酸为底物的二肽酶活性的变化則与对照組基本相似。癌前期TP及TTA活性較对照組都无明显差异。肝癌組織中GSSGR活性与正常肝相似,但在引癌过程中(4—13周)則有升高趋势。苏氨酸去水酶受基础食料中营养因素的影响較大,癌前期看不出3'-MeDAB对它的影响。非致癌物,2-MeDAB,除了使GDH活性升高外,对上述其他酶活性都无明显的影响。肝癌綫粒体內GMA和GDH比活性都較对照組及正常肝綫粒体为低。癌前期肝綫粒体GMA比活性較对照組显著降低,而GDH比活性則无明显改变。根据本实驗及其他实驗室結果,我們认为:3'-MeDAB所引起的肝脏酶活性变化,可能是由于它在肝內进行代謝引起G-6-P旁路代謝的活跃,以及3'-MeDAB代謝产物通过各种不同机制对酶的影响所致。这些酶活性的变化可能导致肝細胞的异常生长和异常分化因而形成肝癌(图12)。非致癌物,2-MeDAB,可能与3'-MeDAB的代謝途径不同,因而产生不同的影响,而3'-MeDAB所产生的特殊影响則可能与其致癌作用有关。

(1) A comparative study has been made on the induction of tryptophan pyrrolase by substrate and corticoids in liver tumor and the precancerous liver induced by 3'-MeDAB.(2) The liver tumor, contrary to normal liver, was inactive in response to both tryptophan and hydrocortisone for the induction of tryptophan pyrrolase, while the tissue adjacent to the tumor was active with respect to both substrate and hormonal induction.(3) A decrease in both substrate and hormonal induction was observed in the precancerous...

(1) A comparative study has been made on the induction of tryptophan pyrrolase by substrate and corticoids in liver tumor and the precancerous liver induced by 3'-MeDAB.(2) The liver tumor, contrary to normal liver, was inactive in response to both tryptophan and hydrocortisone for the induction of tryptophan pyrrolase, while the tissue adjacent to the tumor was active with respect to both substrate and hormonal induction.(3) A decrease in both substrate and hormonal induction was observed in the precancerous liver developed by feeding 3'-MeDAB for different time intervals. In experiments by injecting intraperitoneally the carcinogen into animals,for 25 hours, similar results were obtained as in the feeding experiments.(4) 2-MeDAB, a non-carcinogenic substance, caused the same effect on the induction of tryptophan pyrrolase in every case as did 3'-MeDAB. It thus appears that the effect of 3'-MeDAB on the enzyme induction may not be specific.(5) No inhibitors of tryptophan pyrrolase or activators of kynureninase were found in the cell sap of liver tumor and the liver of rats fed 3'-MeDAB or 2-MeDAB in the course of induction.(6) The cell sap from liver tumor (non-induced) contained only a small amount of enzyme protein, as shown by the fact that the enzyme activity being only slightly increased by the addition of either normal microsome or hematin, of which the level has not elevated by the administration of tryptophan or hydrocortisone.(7) Similar experiments have shown that the cell sap from the substrate and hormonal induced liver in the precancerous stage contained a decreased amount of enzyme protein as compared to that of the control. The same was true of the rats fed 2-MeDAB.(8) Microsomes from liver tumor have lost almost completely the ability of activating tryptophan pyrrolase in the cell sap. The ability of activation due to microsomes from the precancerous liver was remarkably reduced, though not yet completely lost, while the microsomes from the liver of rats fed 2-MeDAB were normal. It was in this respect that the effect of non-carcinogen (2-MeDAB) was found to be different from that of the carcinogen (3'-MeDAB).(9) From the results presented, it was concluded that the default of tryptophan pyrrolase induction observed in the liver tumor and the precancerous liver was mainly due to an inadequate amount of apoenzyme, rather than a deficiency of co-factor (hematin) or an increment of protein other than the enzyme. The possible cause of these effects was briefly discussed.

本文对大鼠肝癌及癌前期肝内TP的底物诱导和激素诱导作了比较研究。在3′-MeDAB诱发的肝癌中,TP活性很低,且不因注射色氨酸或氢可地松而升高,而癌周组织则仍保留对底物和激素诱导的能力。喂3′-MeDAB 13天、28天、90天大鼠肝内TP的底物诱导效应都较对照组为低。急性注射3′-MeDAB25小时,以100毫克/100克体重的L-色氨酸进行诱导,TP的诱导效应亦较对照组为低。氢可地松诱导的结果与底物诱导的相似,无论在喂或急性注射3′-MeDAB的情况下,TP的诱导效应都受到抑制。但在相同条件下,非致癌物,2-MeDAB,对TP的底物诱导和激素诱导(慢性的或急性的实验)也有相似的作用。诱导后肝癌组织或喂偶氮染料的肝组织中都未发现有TP的抑制物或狗尿酸酶的激活物。微粒体及正铁血红素与上清液的加合实验表明:(1)肝癌微粒体几乎完全不具有激活TP的活力;癌前期(3′-MeDAB组)肝微粒体已部分失去此种生化功能,但2-MeDAB组微粒体则否。3′-MeDAB对肝微粒体中辅助因子(正铁血红素)的结构并无破坏,而可能使辅助因子的含量减少。(2)微粒体对激活上清液TP的效果较自由的正铁血红素差,即使加入过量...

本文对大鼠肝癌及癌前期肝内TP的底物诱导和激素诱导作了比较研究。在3′-MeDAB诱发的肝癌中,TP活性很低,且不因注射色氨酸或氢可地松而升高,而癌周组织则仍保留对底物和激素诱导的能力。喂3′-MeDAB 13天、28天、90天大鼠肝内TP的底物诱导效应都较对照组为低。急性注射3′-MeDAB25小时,以100毫克/100克体重的L-色氨酸进行诱导,TP的诱导效应亦较对照组为低。氢可地松诱导的结果与底物诱导的相似,无论在喂或急性注射3′-MeDAB的情况下,TP的诱导效应都受到抑制。但在相同条件下,非致癌物,2-MeDAB,对TP的底物诱导和激素诱导(慢性的或急性的实验)也有相似的作用。诱导后肝癌组织或喂偶氮染料的肝组织中都未发现有TP的抑制物或狗尿酸酶的激活物。微粒体及正铁血红素与上清液的加合实验表明:(1)肝癌微粒体几乎完全不具有激活TP的活力;癌前期(3′-MeDAB组)肝微粒体已部分失去此种生化功能,但2-MeDAB组微粒体则否。3′-MeDAB对肝微粒体中辅助因子(正铁血红素)的结构并无破坏,而可能使辅助因子的含量减少。(2)微粒体对激活上清液TP的效果较自由的正铁血红素差,即使加入过量微粒体亦不能使TP活性增高到加入正铁血红素的水平;微粒体对3′-MeDAB组上清液的激活不如对2-MeDAB组及对照组上清液(底物或激素诱导)的激活显著,而正铁血红素对三组上清液都有显著激活。(3)肝癌细胞上清液只合有极少量的TP蛋白,且不因注射色氨酸或氢可地松而增加;癌前期肝细胞上清液的TP蛋白因底物或激素诱导而增加的量都较对照粗低。2-MeDAB组也有相似现象。以上结果表明,肝癌及癌前期肝内TP诱导的受损,主要是由于诱导后TP蛋白的缺少,而不是由于辅助因子(如正铁血红素)的不足,或非酶蛋白的增多。

 
<< 更多相关文摘    
图标索引 相关查询

 


 
CNKI小工具
在英文学术搜索中查有关作用的内容
在知识搜索中查有关作用的内容
在数字搜索中查有关作用的内容
在概念知识元中查有关作用的内容
在学术趋势中查有关作用的内容
 
 

CNKI主页设CNKI翻译助手为主页 | 收藏CNKI翻译助手 | 广告服务 | 英文学术搜索
版权图标  2008 CNKI-中国知网
京ICP证040431号 互联网出版许可证 新出网证(京)字008号
北京市公安局海淀分局 备案号:110 1081725
版权图标 2008中国知网(cnki) 中国学术期刊(光盘版)电子杂志社