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八臂迷宫
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  eight-arm maze task
     Effect of Ww-nitro-L-arginine on working memory of rats in eight-arm maze task
     Nω-硝基-L-精氨酸对大鼠八臂迷宫工作记忆的作用(英文)
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  8-arm radial maze
     Effect of H_1 antagonists on spatial memory deficit evaluated by 8-arm radial maze in rats
     组胺H_1受体阻断剂对大鼠八臂迷宫空间记忆的影响<英文>
短句来源
     Neurological function was examined up to 28 days after ischemia and then learning and memory evaluated using 8-arm radial maze on days 30~35 after ischemia.
     缺血后第1~28天进行神经症状评分,第30~35天采用八臂迷宫评价学习记忆功能。
短句来源
     So our AIM: To investigate whether or not exogenous and endogenous histamine is involved in spatial memory deficits induced by dizocilpine (MK-801) asevaluated by 8-arm radial maze of rats.
     因此本文的目的:研究和阐明海马外源性和内源性组胺对地佐环平(MK-801)诱发大鼠的八臂迷宫记忆障碍的作用及探讨海马组胺受体在空间记忆中的作用。
短句来源
     Methods Forty-two Kun-ming mice were divided into four groups : 8-arm radial maze-stressed group ( A) . 8-arm radial maze of non-stressed group (B) , Barnes maze of stressed group(C) , Barnes maze of non-stressed group(D).
     方法 雄性昆明小鼠42只随机分成4组,即:八臂迷宫心理应激组(A)、八臂迷宫对照组(B)、Barnes迷宫心理应激组(C)、Barnes迷宫对照组(D),每组10只。
短句来源
     The changes of learning and memory behavior of mice were respectively observed with 8-arm radial maze and Barnes maze after 2 day psychological stress.
     旁观应激2d后,用放射状八臂迷宫和Barnes迷宫进行空间学习记忆能力的测试。
短句来源
  radial arm maze
     IVHA at a dose of 0. 2 mg . kg-1 ip significantly reversed scopolamine-induced working memory and reference memory impairments in radial arm maze.
     ip给与IVHA0.2 mg·kg~(-1)翻转东莨菪碱导致的八臂迷宫记忆障碍.
短句来源
  “八臂迷宫”译为未确定词的双语例句
     METHODS: Eight-arm radial maze performance was used to measure spatial memory in rats.
     方法:采用八臂迷宫学习的程序研究大鼠的空间记忆。
短句来源
     Microdialysis in CA3 of hippocampus in adult mice for real-time monitoring of extracellular excitatory amino acids EAAs (GLU and aspartate) and GABA dynamics showed that 4-hour hypoxia both of 2 km and 5 km enhanced concentration of GLU and ASP and reduced extracellular GABA.
     出生后3周或4周2千米低氧也显著减少雄性和雌性小鼠(P60-68)在八臂迷宫中所犯错误次数。
短句来源
     However, little is known about the involvement of the hippocampal NMDA receptor in amelioration of histaminergic system and it remains to be unknown whether working memory, a kind of short-term memory, or reference memory, a kind of long-term memory, is prominently related to histamine.
     本实验采用的八臂迷宫可以有效地排除动物由于自身运动机能障碍而对学习和记忆观察指标的影响,还可以同时有效地分离和分析动物工作记忆与参照记忆,即短时记忆和长时记忆。
短句来源
     METHODS: 8-Arm (4-arm baited) radial maze was used to measure spatial memory in rats.
     方法:采用八臂迷宫(四臂放饵)来研究大鼠的空间记忆。
短句来源
     1 The effects of histamine on MK-801-induced spatial memorydeficits in SD ratsRecently, the differentiation of functions along the longitudinal axis of the hippocampus (dorsal-ventral in the rat and posterior-anterior in humans) has attracted interest.
     1 组胺对大鼠海马腹侧内局部注射地佐环平诱发的八臂迷宫空间记忆障碍的改善作用海马在学习记忆中起很重要的作用,而最近,海马沿着长轴的功能分化成为很多研究的兴趣所在。
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  8-arm radial maze
Mice permitted to explore an 8-arm radial maze tended to visit those arms least recently entered.
      
All rats were tested (i) for home cage activity, (ii) for activity and reactivity in an open field and (iii) for learning ability in a 8-arm radial maze.
      
The errors in the 8-arm radial maze trial were increased at 1 month.
      
Dramatic impairments in spatial learning in the win-shift 8-arm radial maze were seen in both EC-SOD knockout mice and EC-SOD overexpressing mice.
      
Control (N = 17) and EC-SOD overexpressing mice (N = 13) acquired the 8-arm radial maze over 21 sessions of training.
      
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  radial arm maze
Results are presented in male and female rats utilizing cognitive tests that assess visual (object recognition) and spatial memory (object placement and radial arm maze) following chronic amphetamine, methamphetamine, or daily restraint stress.
      
Older gerbils exhibit significantly higher errors in a radial arm maze than younger animals, but older gerbils that had received chronic daily treatments of PBN (32 mg/kg) for 14 days committed significantly less errors than untreated controls.
      
Amphetamine-induced perseverative behavior in a radial arm maze following DSP4 or 6-OHDA pretreatemnt
      
The effect of pramiracetam (CI-879) on the acquisition of a radial arm maze task
      
The effect of the nootropic drug pramiracetam (CI-879) on acquisition of a radial arm maze task was examined in the rat.
      
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AIM:To study the effects of isovanihuper-zine A (IVHA) on cholinesterase and scopo-lamine-induced memory deficit. METHODS: AChE and BuChE activities were determined by the colorimetric method of Ellman. The K, value was determined by the plotting method of Lineweaver and Burk. In a behavioral test, fats were trained to perform a radial arm maze task using a partially baited procedure. RESULTS: The anti-AChE activity of IVHA was comparable to huperzine A (Hup-A) , and was more potent than those of physostigmine...

AIM:To study the effects of isovanihuper-zine A (IVHA) on cholinesterase and scopo-lamine-induced memory deficit. METHODS: AChE and BuChE activities were determined by the colorimetric method of Ellman. The K, value was determined by the plotting method of Lineweaver and Burk. In a behavioral test, fats were trained to perform a radial arm maze task using a partially baited procedure. RESULTS: The anti-AChE activity of IVHA was comparable to huperzine A (Hup-A) , and was more potent than those of physostigmine and galanthamine with an IC50 value of 0. 11 umol.L-1.IVHA was a mixed competitive type with a Ki value of 32 nmol .L-1. It bound to AChE in a reversible manner. IVHA at a dose of 0. 2 mg .kg-1 ip significantly reversed scopolamine-induced working memory and reference memory impairments in radial arm maze. CONCLUSION: IVHA is a new potential reversible AChE inhibitor and merits further study as a cognitive enhancer.

目的:研究石杉碱类似物异香兰石杉碱甲(IVHA)对胆碱酯酶的抑制作用和东莨菪碱导致的记忆障碍的影响.方法:乙酰胆碱酯酶和丁酰胆碱酯酶活力用Ellman比色法测定.抑制常数K_i值抑制机制用Lineweaver和Burk的双倒数作图法测定.行为测试用八臂迷宫装置.结果:IVHA的抗AChE作用稍弱于Hup-A.它对红细胞膜AChE的IC_(50)为0.11 μmol·L~(-1).作用强于Phys和Gal.属混合型抑制剂,K_i值为32 nmol·L~(-1).不同于异氟磷,与AChE为可逆性结合.ip给与IVHA0.2 mg·kg~(-1)翻转东莨菪碱导致的八臂迷宫记忆障碍.结论:IVHA是一个新的强效可逆胆减酯酶抑制剂,值得进一步研究.

To study the effect of Mw-nitro-L-arg-inine (NNA) (a NO synthase inhibitor) on memory in the rats. METHODS: A delayed non-match-to-sample (DNMTS ) eight-arm maze task was used to study spatial working memory. RESULTS: Intraperitoneal injection of NNA 100 mg kg-1 before the trial or at the start of the delay did not affect the accuracy , while pretraining administration of scopolamine 0. 25 mg kg-1 produced impairment in mnemonic performance as evidenced by fewer correct choices after the delay and more total...

To study the effect of Mw-nitro-L-arg-inine (NNA) (a NO synthase inhibitor) on memory in the rats. METHODS: A delayed non-match-to-sample (DNMTS ) eight-arm maze task was used to study spatial working memory. RESULTS: Intraperitoneal injection of NNA 100 mg kg-1 before the trial or at the start of the delay did not affect the accuracy , while pretraining administration of scopolamine 0. 25 mg kg-1 produced impairment in mnemonic performance as evidenced by fewer correct choices after the delay and more total errors to complete the task. Intracerebroventricular infusion of NNA (10, 50, 100 nmol) did not affect the accuracy. CONCLUSION: A single ip or icv injection of NNA is not sufficient to alter the memory formation and use in this DNMTS eight-arm maze task.

目的:研究一氧化氮合成酶抑制剂N_ω-硝基-L-精氨酸(NNA)对大鼠空间工作记忆的作用.方法:采用八臂迷宫延迟插板的程序.结果:腹腔注射NNA 100 mg kg~(-1)对大鼠八臂迷宫选择的准确性没有显著影响,只能增加反应的潜伏期.东莨菪碱0.25 mg kg~(-1)使大鼠延迟后的错误选择显著增加.脑室内注射NNA(10,50,100 nmo1/1 μL)没有影响准确性.结论:急性NNA给予对大鼠空间工作记忆的形成和使用没有显著影响.

AIM: To study the effects of huperzine A on nucleus basalis magnocellularis (NBM) lesion induced spatial working memory impairment. METHODS: A delayed non match to sample radial arm maze task was used to study spatial working memory. The choline acetyltransferase (ChAT) activity was determined by the conversion of acetyl CoA to ACh . RESULTS: Unilateral NBM lesion by kainic acid 0 02 μmol impaired rats ability to perform this working memory task as evidenced by fewer correct choices after different...

AIM: To study the effects of huperzine A on nucleus basalis magnocellularis (NBM) lesion induced spatial working memory impairment. METHODS: A delayed non match to sample radial arm maze task was used to study spatial working memory. The choline acetyltransferase (ChAT) activity was determined by the conversion of acetyl CoA to ACh . RESULTS: Unilateral NBM lesion by kainic acid 0 02 μmol impaired rats ability to perform this working memory task as evidenced by fewer correct choices after different delay intervals and more total errors to complete the task. This behavioral impairment associated with a decrease in the activity of ChAT by about 40 % in the ipsilateral cerebral cortex. Huperzine A (0 2 mg·kg -1 ip 30 min before testing) ameliorated this spatial working memory impairment. Physostigmine (0 2-0 3 mg·kg -1 ip 20 min before testing) also attenuated the NBM lesion induced memory deficit. CONCLUSION: The integrity of NBM is critical for spatial working memory processing, and this working memory impairment induced by NBM lesion can be ameliorated by huperzine A and physostigmine.

目的:研究石杉碱甲对基底核大细胞部(NBM)损毁诱导的工作记忆障碍的影响.方法:采用八臂迷宫延迟插板的程序研究空间记忆.胆碱乙酰转移酶(ChAT)活力测定采用[3H]乙酰辅酶A转变成[3H]乙酰胆碱的方法.结果:单侧损毁NBM(卡因酸002μmol)导致空间记忆障碍.在不同的延迟间隔,大鼠完成程序产生的正确数减少和错误数增多.损毁侧大脑皮层ChAT酶的含量下降了大约40%.石杉碱甲(02mg·kg-1实验前30minip)改善这种空间记忆障碍.毒扁豆碱(02-03mg·kg-1实验前20minip)也有改善作用.结论:完整的NBM是空间记忆形成的关键.石杉碱甲有效的改善NBM损毁导致的空间记忆障碍.

 
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