It suggested that therapy which could regulate microcirculation function, decrease viscosity of blood, and decrease platelet aggregation function may be used, instead of cytotoxic treatment which possess high side—effect and the risk of carcinogenicity.
P-selectins were involved in the pathologic course of the acute cerebral ischemia, Aspirin had the efficacy of decreasing platelet activation and diminishing the brain injury.
Conclusion: rh-IL-11 is effective in prevention of chemotherapy-induced thrombocytopenia, decreasing platelet infusions and shorten myelodepression period in patients with solid tumors.
Viscosity of whole blood and plasma, and the rate of platelet aggregation lowered significantly after treatment (P <0.01), but had no difference from those of control group.
This drug (0.675g/kg) can reduce platelet amount and prolong coagulation time of male rats,and if its dosage is 1.35g/kg,it can have the same action to all rats.
The formation of HHT and 12-HETE from endogenously released AA in washed rat platelets was dose-dependently reduced by anisodamine (654-2), while the conversion of exogenously added AA to HHT and 12-HETE was not affected by 654-2.The results of the present study indicate that 654-2 decreased the formation of HHT and 12-HETE in washed rat platelets by inhibiting the release of endogenous AA.
Repeated intramuscular administration of low molecular weight heparin-collagen complex proved to increase fibrinolytic activity and to decrease platelet aggregation in the blood of rats (11 months) with depressed anticoagulant system.
Few platelets adhered to the fluorocarbon surfaces preadsorbed with serum, while preadsorption with plasma selectively-depleted of either fibronectin, vitronectin, or von Willebrand factor did not decrease platelet adhesion significantly.
Conclusion: This longitudinal study suggests that therapeutic doses of lithium significantly decrease platelet membrane PIP2 levels in vivo in bipolar disorder subjects, which may be related to lithium's mechanism of action in bipolar disorder.
The findings suggest that co-dergocrine might be able to decrease platelet activity and improve interaction with the walls of to a blood-vessel significant degree.
15-HPETE does not modify platelet prostaglandin and thromboxane formation from exogenous arachidonic acid but does decrease platelet lipoxygenase activity.
Note the progressive decrease in binding with decreasing platelet count.
例句来源
This prevents the eventual formation of thromboxane A2, thus decreasing platelet aggregation.
例句来源
The formation of intimal hyperplasia in venous autograft and at anastomosis between graft and artery in non-human Primates was inhi- bited by oral application of aspirin and dipyridamole. In order to Sea- rch the possible mechanism, the effects of aspirin and dipyridamole on platelet function were studied. Results suggested that ① the platelet ag- gregability in response to collagen, platelet serotonin release and pla- telet arachidonic acid metabolism were affected by daily ingestion of a- spirin (325mg) a...
Thirty-two patients suffering from various malignant tumors were treated with high dose of methotrexate and followed by citrovorum factor rescue (HD-MTX-CFR) were reported. A total of 42 courses of HD-MTX-CFR were administered to these patients. Dosage of MTX varied from 1.0 to 5.0g once and CF 9-15mg every 6 hours for 3 days.Six patients with malignant lymphomas showed tumor remission after treatment, but in lung cancer it was unsuccessful.The common side effects of HD-MTX-CFR therapy in our series were le...
This paper is to report the study of the microscopic and macroscopic he-morrheological changes and the conditions of the nail-fold microcirculation in 30 patients with severe viral hepatitis. Normal 'individuals, patients with acute icteric hepatitis, and those with chronic active hepatitis were employed as the controls.The changes observed in the patients with severe viral hepatitis were as follows: The reduced viscosity of the whole blood and the plasma viscosity increased markedly, the dispersion rate of...