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icr小鼠     
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  icr mice
     Results Survival rates of IRM-2 for 100 μg, 150 μg, 200 μg were 55% , 75% , 85% , respectively. These were 35% , 30% and 20% higher than those of ICR mice.
     结果IRM-2小鼠100μg/0.2 ml、150μg/0.2 ml、200μg/0.2 ml存活率与对照组比较分别提高55%、75%、85%,ICR小鼠提高35%、30%、20%。
     Radiation-Protective Effect of E_(838) on IRM-2 and ICR Mice
     E_(838)对IRM-2和ICR小鼠的辐射防护作用
短句来源
     The establishment of the model in ICR mice with B16 melanoma of C57BL/6 mice
     C57BL/6小鼠黑色素瘤B16细胞株在ICR小鼠肿瘤模型的建立
短句来源
     Radiation Protective Effect of E838 on IRM2 and ICR Mice
     E838对IRM-2和ICR小鼠的辐射防护作用
     Methods Healthy female ICR mice were divided into 8 groups at random as normal control group(N),model group(M),model control group(MC)and administering group(administration interval:30min、1 h、1.5 h、2 h、3 h).
     方法将健康雌性ICR小鼠随机分为正常对照组(normal control group,N)、模型组(model group,M)、模型对照组(model control group,MC)以及5个时相给药组(30 min、1 h1、.5 h、2 h、3 h),共8组。
短句来源
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  icr mouse
     Isolation and culture of ICR mouse embryonic stem cells and its identification
     ICR小鼠胚胎干细胞的分离、培养及鉴定
短句来源
     Aim To study the persistence of experimental Escherichia coli O157∶H7 EDL933 strain in ICR mouse Methods ICR mice were inoculated via oral gastric inoculation with 0 1ml~0 9ml of EDL933 strain 7 0×10 8~4 0×10 9CFU/ml;
     方法 ICR小鼠经口感染 ,剂量为 0 1~ 0 9ml(菌悬液浓度为 7 0× 10 8~ 4 0× 10 9CFU/ml) ,并在SPF动物实验室中饲养。 结果 不同实验动物微生物等级的ICR小鼠对EDL933株表现出不同感染类型 ,Ⅰ级小鼠感染未成功 ;
短句来源
     Comparative Study of Hepatoxicity Induced by Genipposide in SD Rat,Wistar Rat and ICR Mouse
     京尼平苷对SD大鼠,Wistar大鼠与ICR小鼠肝毒性的比较研究
短句来源
     Objective: To establish feeder layer culture system of ICR mouse embryonic fibroblast(MEF) cells for isolation and culturing of embryonic stem(ES) cells.
     目的:建立ICR小鼠胚胎成纤维细胞饲养层培养体系,用于胚胎干细胞建系及研究。
短句来源
     And the expression product can alleviate the symptoms of liver trauma of ICR mouse.
     通过对ICR小鼠的急性肝损伤实验,测得蚕蛹表达产物能明显降低肝脏血清酶活性。
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  the icr mice
     Methods The ICR mice were orally perfused with sodium selenite (Na2SeO3) at different concentrations of 2.5,5.0 and 10 mg/kg and lead acetate [Pb(Ac)2] at different concentrations of 5,10 and 25 mg/kg jointly and con-tinuously for 3 days, and then the numbers of bone marrow polychromative erythrocytes were counted.
     方法 给予ICR小鼠经口灌胃不同浓度的亚硒酸钠(Na2SeO32.5、5.0和10mg/kg)和醋酸铅[Ph(Ac)2 5、10和25mg/kg],连续3d,进行骨髓嗜多染红细胞微核计数。
短句来源
     Sister chromatid exchange test in ICR mice with cyclophosphamide was conducted. The ICR mice weretreated at doses of 1,5,10,15,20,25 mg/kg body weight.
     用环磷酰胺(Cy)作诱变剂,分6个剂量组(1,5,10,15,20,25mg/kg)进行了 ICR 小鼠活体姐妹染色单体交换(SCE)试验。
短句来源
     METHODS: The experiment was carried out in the Department of Pathogenic Biology,Nanjing Medical University from September 2004 to July 2005. 1The mIA-2i and mIgG Fc were expended from the brain tissue and spleen of the ICR mice by RT-PCR method to import into the corresponding enzyme sites (XhoⅠ/ BamHⅠand BamHⅠ/EcoR I) respectively.
     方法:实验于2004-09/2005-07在南京医科大学病原生物学系完成。 ①采用反转录-聚合酶链反应方法从ICR小鼠的脑组织和脾脏中分别扩增胰岛细胞瘤相关蛋白2胞内区(mIA-2i)和IgGFc段(mIgGFc),并引入相应的酶切位点(XhoⅠ/BamHⅠ和BamHⅠ/EcoRI)。
短句来源
     TMTD had mutagenic activities in Ames tests with S. Typhimurium strains TA100 and TA97, and S9 may enhance the mutagenic activity. The micronuclear test of the ICR mice showed that the frequencies of MUPCE were increased significantly by injecting intraperitoneally TMTD with the dose of 28 mg/kg bw.
     在鼠伤寒沙门氏菌试验中TMTD对TA_(100)及TA_(98)显示致突变活性,加入S_9致变活性增加,ICR小鼠骨髓微核试验表明,一次腹腔注入28mg/kg体重,多染红细胞微核率(MUPCE)显著增加,呈剂量-效应相关(r=0.939,P<0.01)。
短句来源
     The ICR mice bone marrow nucleated cells(BMNC) were cryopreserved by vitrification. After cryopreservation for 1,5,10,20 and 30 days, the individual samples were separately thawed in 38℃ water bath or by microwave treatment in 300mL 10℃ water under microwave power of 800W, frequency of 2450MHz and thawing duration of 80s, following which the viability of BMNC was assayed.
     对ICR小鼠骨髓有核细胞进行玻璃化深低温保存,在冻存1、5、10、20、30d后,骨髓有核细胞样品分别采用常规的38℃水浴复温和微波复温即在300mL 10℃水中,控制微波功率为 800W,频率2450MHz,复温时间80s。
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  icr rats
     Methods: Feed male ICR rats with cold- food diet under cool dry environment, stimulate with electric foot shocks to establish abnormal savda syndrome animal model in Uighur medicine.
     方法:选用ICR小鼠,在阴凉环境下,采用干寒属性饲料饲养、慢性足底电击等多因素复合作用建立维吾尔医异常黑胆质证载体动物模型。
短句来源
     Abstract By way of producing induced inflammation on ICR rats and SD rats by dimethy benzene,induced pain by acetic acid and induced fever by dry yeast,we made studies on pharmacodynamics of Qing Dan Tang.
     实验将ICR小鼠和SD大鼠采用二甲苯致炎、醋酸致痛及干酵母致热等方法,对清胆汤的药效学作用进行研究。
短句来源
     Methods: Male ICR rats were fed with cold- food diet under cool dry environment, stimulate with electric foot shocks to establish abnormal savda syndrome animal model in Uighur medicine.
     方法:选用ICR小鼠,通过采用干寒饲养环境、干寒属性的饲料饲养、间断足底电击等多因素的复合作用,建立小鼠异常黑胆质载体动物模型(造模组)。
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  icr mice
Twenty-five tiptoe-walking Yoshimura (twy) mice with calcified mass lesions compressing the spinal cord posterolaterally at the C1-C2 vertebral levels were compared with five Institute of Cancer Research (ICR) mice that served as controls.
      
albicans) in mice, the fungal vaginitis model was established in female ICR mice by intravaginal inoculation of suspension of C.
      
To study the effect of itraconazole on the vaginal candidiasis caused by Candida under different immunity conditions, the fungal vaginitis model was established in female ICR mice by intravaginal inoculation of suspension of C.
      
The relationship between Ni-induced hepatic lipid peroxidation (LPO) and the concentrations of Ni and trace elements was investigated in male ICR mice.
      
The l-SeMet α,γ-elimination enzyme was ubiquitous in tissues from ICR mice and the activity was relatively high in the large intestine, brain, and muscle, as well as the liver.
      
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  icr mouse
ICR mouse embryos at the two-cell stage obtained by flushing the oviducts were frozen by two cryopreservation procedures, slow freezing using a programmable freezer or vitrification by direct plunging into liquid nitrogen.
      
The tail was flexed towards the left side of the body in 5.2 and 6.2% of ICR mouse embryos at 10.5 and 11.5 days of gestation respectively.
      
In the present study to analyze the role of ACTH in fetal tissues and organs, we observed the expression of melanocortin type 2 (MC2) and 5 (MC5) receptors in ICR mouse embryos from E11.5 to E18.5 by immunohistochemistry.
      
These recoveries were all higher than those in a previous report of 22 (7.3%) worms recovered from a single Institute of Cancer Research (ICR) mouse exposed to 300 cysts 22?days prior to necropsy.
      
The duodenum and ileum of 15 to 18-day old Swiss ICR mouse embryos were studied with the electron microscope to follow the differentiation of endocrine cells.
      
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  the icr mice
We then assessed the acute toxicity of the small molecules on the ICR mice by administrating TGG and luteolin intraperitoneally.
      
  其他


Recently a series of studies on tumor hyperthermia therapy have shown that the hyperthermia at 42°~45℃ could induce selective tumor killing effect, but there were rather few reports about the hyperthermia cembind with chemotherapy.The experiment on the effect of hyperthermia combined with pingyangmycin (PYM) on sarcoma 180 transplated into the rear legs of ICR mice was carried out. The 2450 MHz microwave was used as the local hyperthermia treatment. The results showed that the tumor inhibition rate of the experimental...

Recently a series of studies on tumor hyperthermia therapy have shown that the hyperthermia at 42°~45℃ could induce selective tumor killing effect, but there were rather few reports about the hyperthermia cembind with chemotherapy.The experiment on the effect of hyperthermia combined with pingyangmycin (PYM) on sarcoma 180 transplated into the rear legs of ICR mice was carried out. The 2450 MHz microwave was used as the local hyperthermia treatment. The results showed that the tumor inhibition rate of the experimental group (71.27%) was much higher than that of the control group (33.09%, and 25.03%).From May 1980 to March 1981, 20 patients with squamous cell carcinoma of oral and maxillofacial regions were treated by 2450 MHz microwave local hyperthermia combined with PYM and MTX chemotherapy The local response was evaluated at the end of one course. The result showed good in 7 cases (35%) and fair in 10 cases (50%), the total response rate was 85% (17/20), which was better than that of chemotherapy alone (p<0.05).

本文通过动物实验证明:对ICR小鼠后肢的S 180移植瘤,用2450 MHz微波局部加温联合全身应用平阳霉素治疗,与对照组比较,有较高的抑瘤率(71.27%),统计学上有显著差异。临床上,用2450 MHz微波联合平阳霉素及氨甲喋呤治疗20例口腔颌面部鳞癌,近期肿病完全消退者7例(35%),肿病消退50%以上者10例(5O%),总有效率为85%(17/20),比单用同类化疗药物的近期疗效有显著提高(P<0.05)。

Technical Antioxidant D (D) and its main constituent,N-phenyl-2-na-phthylamine (PBNA),were dissolved respectively in dimethyl sulfoxide and injected subcutaneously twice weekly into young adult male ICR mice at individual dosages of 12 or 4mg for 35 injections.At the end of the 8th experimental month surviving ani-mals were killed and 20 animals from each group underwent detailed auto-psy and histological examination.45% malignant tumors,mostly pulmonary carcinomas,were found both in D and PBNA groups that had...

Technical Antioxidant D (D) and its main constituent,N-phenyl-2-na-phthylamine (PBNA),were dissolved respectively in dimethyl sulfoxide and injected subcutaneously twice weekly into young adult male ICR mice at individual dosages of 12 or 4mg for 35 injections.At the end of the 8th experimental month surviving ani-mals were killed and 20 animals from each group underwent detailed auto-psy and histological examination.45% malignant tumors,mostly pulmonary carcinomas,were found both in D and PBNA groups that had received total doses of 420 mg of substances to be tested.There seemed to be a dose-response correlation for the carcinogene-city of PBNA to ICR mice.No tumor was found in the 20 mice injected re-peatedly with dimethyl sulfoxide.

以国产工业D防和其提纯的主要成份N-苯基-2-萘胺(PBNA)溶于二甲亚砜,每周两次皮下注射于雄性刚成年ICR小鼠,剂量每次12毫克或4毫克,共35次。实验八个月末检查实验及二甲亚砜对照动物每组20头,发现12毫克×35次工业D防和同剂量PBNA各诱发45%恶性肿瘤,其中大部为肺癌。PBNA对小鼠致癌性可能有剂量一反应关系。二甲亚砜对照组20头小鼠无任何肿瘤。

In this study α—naphthyl acetate was used as substrate to show esterase activi(?)y.The distribution of esterase in the kidneys of adult ICR mouse was essentially in agreement with the result in the kidneys of dog,rabbit and rat obtained Abe et al,in which the enzyme activity was strongest in proximal tnbules. In the kidneys of the 17—day—old mouse embryos and the kidneys of the newborn mice,esterase activity was in mature nephron of inner cortical zone,the strongest was in proximal tubules.In contrast,the poorly...

In this study α—naphthyl acetate was used as substrate to show esterase activi(?)y.The distribution of esterase in the kidneys of adult ICR mouse was essentially in agreement with the result in the kidneys of dog,rabbit and rat obtained Abe et al,in which the enzyme activity was strongest in proximal tnbules. In the kidneys of the 17—day—old mouse embryos and the kidneys of the newborn mice,esterase activity was in mature nephron of inner cortical zone,the strongest was in proximal tubules.In contrast,the poorly differentiated outer cortical zone was weak or showed no activity.This result is identical with that of kidneys of the newborn guinea pig and rat reported by wachstein et al.However,the time that esterase occurred was earlier than that reported by Hunter and Han Xuemei.

本文以α—醋酸萘酯为底物显示酯酶活性,在成年 ICR 小鼠肾酯酶的分布与 Abe 等人在狗、兔、大鼠肾所得的结果基本一致,即酶活性最强定位在近曲小管。第17天鼠胚肾和新生鼠肾皮质内带成熟的肾单位出现明显的酯酶活性,最强在近曲小管;而皮质外带肾单位分化程度较低,酯酶活性很弱,甚至无活性。这与 Wachsten 等人在新生豚鼠和大鼠肾所观察的结果一致。但酯酶的出现时间比 Hunter 和韩雪梅所报道的早些。

 
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