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  icr mice
Twenty-five tiptoe-walking Yoshimura (twy) mice with calcified mass lesions compressing the spinal cord posterolaterally at the C1-C2 vertebral levels were compared with five Institute of Cancer Research (ICR) mice that served as controls.
      
albicans) in mice, the fungal vaginitis model was established in female ICR mice by intravaginal inoculation of suspension of C.
      
To study the effect of itraconazole on the vaginal candidiasis caused by Candida under different immunity conditions, the fungal vaginitis model was established in female ICR mice by intravaginal inoculation of suspension of C.
      
The relationship between Ni-induced hepatic lipid peroxidation (LPO) and the concentrations of Ni and trace elements was investigated in male ICR mice.
      
The l-SeMet α,γ-elimination enzyme was ubiquitous in tissues from ICR mice and the activity was relatively high in the large intestine, brain, and muscle, as well as the liver.
      
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Thiram (TMTD) is widely used as a vulcanization accererator for rubber products, and a fungicide for seeds, fruits, and vegetables. TMTD had mutagenic activities in Ames tests with S. Typhimurium strains TA100 and TA97, and S9 may enhance the mutagenic activity. The micronuclear test of the ICR mice showed that the frequencies of MUPCE were increased significantly by injecting intraperitoneally TMTD with the dose of 28 mg/kg bw. A dose-response correlation was seen (r = 0.939, P<0.01) . The rate ofchromosal...

Thiram (TMTD) is widely used as a vulcanization accererator for rubber products, and a fungicide for seeds, fruits, and vegetables. TMTD had mutagenic activities in Ames tests with S. Typhimurium strains TA100 and TA97, and S9 may enhance the mutagenic activity. The micronuclear test of the ICR mice showed that the frequencies of MUPCE were increased significantly by injecting intraperitoneally TMTD with the dose of 28 mg/kg bw. A dose-response correlation was seen (r = 0.939, P<0.01) . The rate ofchromosal aberration was 10-12%, using the cultured CHL cell in vivo.

二硫化四甲基秋兰姆(TMTD)是橡胶促进剂并广泛用作种子、水果、蔬菜的杀真菌剂。在鼠伤寒沙门氏菌试验中TMTD对TA_(100)及TA_(98)显示致突变活性,加入S_9致变活性增加,ICR小鼠骨髓微核试验表明,一次腹腔注入28mg/kg体重,多染红细胞微核率(MUPCE)显著增加,呈剂量-效应相关(r=0.939,P<0.01)。体外培养CHL,细胞的染色体畸变试验显示,染色体畸变率增至10—12%。 S.D大鼠致畸试验TMTD28,56,112mg/kg体重时,每窝活胎数明显减少,吸收胎,死胎率明显增加,并可见到四肢内翻,脑室扩人,心脏右移,肾移位等改变。研究表明,TMTD是一个致突变物及动物致畸物。

Catecholamic acid(catechol-3, 6-bis(methyleneimino diacetic acid), CBMIDA), a chelating agent, was shown to be effective in treatment of uranium intoxication. But it is possessed of obviously teratogenic and embryotoxic effects on wistar rat embryos.CBMIDA sc 100, 200, .500 mg/kg considerably increased the number of resorbed and teratic fetuses.However, it did not induce chromosome aberrations in CHL cells at the concentration of IC50. CBMIDA did not increase the frequency of micronucleated PCE in ICR mouse...

Catecholamic acid(catechol-3, 6-bis(methyleneimino diacetic acid), CBMIDA), a chelating agent, was shown to be effective in treatment of uranium intoxication. But it is possessed of obviously teratogenic and embryotoxic effects on wistar rat embryos.CBMIDA sc 100, 200, .500 mg/kg considerably increased the number of resorbed and teratic fetuses.However, it did not induce chromosome aberrations in CHL cells at the concentration of IC50. CBMIDA did not increase the frequency of micronucleated PCE in ICR mouse bone marrow. Further studies on effect of CBMIDA on DNA conformation indicate that the CD spectra of calf thymus DNA were not altered by CBMIDA at 50 ug/ml,. It is thought that teratogenesis caused by CBMIDA results not from the effects on DNA or chromosome, but more likely, from chelating which leads to a shortage of metal elements in the body.

双酚胺酸对铀有良好的促排解毒作用,但它却有明显的胚胎毒和致畸作用。用接近治疗的剂量100,250,500mg/kg肌注,引起吸收胎明显增多,甚至达100%。在不同剂量组幸存的鼠活胎中有3.3-6.9%的畸胎。双酚胺酸无诱变作用。在CHL细胞染色体畸变试验中浓度高达LD50时,畸变率仍低于5%。ICR小鼠肌注3000mg/kg后,骨髓多染性红细胞微核率无明显增高。进一步分析双酚胺酸对DNA构象的影响。结果50μg/ml双酚胺酸并不改变小牛胸腺DNA的圆二色谱。表明双酚胺酸既不嵌入DNA分子也不形成加成物,它的致畸作用很可能是螫合作用而导致母鼠缺乏某些金属离子所致,而并不影响DNA或染色体。

Chromosome aberrations indUced by various 60Co γ-ray doses(0-3Gy) were examined in secondary oocytes and bone marrow cells of ICRmice. The chromosome aberration rates of the two cell lines were both significantly higher in γ-irradiated groups than that in control ones. Using four modelsrecommended by WHO, dose-response calibration curves were established and bettermatches were selected= they were Y = 21. 1057 D0.7958,Y = 1. 6502 + 15 .9986 D +3.8533 D2 for aberrant cell and total chromosome aberration rates(%...

Chromosome aberrations indUced by various 60Co γ-ray doses(0-3Gy) were examined in secondary oocytes and bone marrow cells of ICRmice. The chromosome aberration rates of the two cell lines were both significantly higher in γ-irradiated groups than that in control ones. Using four modelsrecommended by WHO, dose-response calibration curves were established and bettermatches were selected= they were Y = 21. 1057 D0.7958,Y = 1. 6502 + 15 .9986 D +3.8533 D2 for aberrant cell and total chromosome aberration rates(% ) of oocytes,respectively. And Y = 29. 8031 D0.5186, Y= 3. 1905 + 27. 1214 D + 8 .5663 D2 for aberrant cell and total chromosome aberration rates(%) of bone marrow cells, respectively. A comparison of radiosensitivity between ME oocytes and bone marrowcells were also made, the results showed that both Ma oocytes and bone marrowcells were sensitive, the bone marrow cell radiosensitivity was higher than that ofM Ⅱ oocytes by 2 .2 times.

用不同剂量(0~3Gy)60Coγ射线一次全身性照射雌性ICR小鼠,观察MⅡ(第二次减数分裂中期)卵母细胞和骨髓细胞染色体损伤效应,用WHO推荐的4个模式进行剂量效应曲线的拟合,选出最优的拟合模式,并对MⅡ卵母细胞和骨髓细胞的量效关系式进行了比较。结果表明,MⅡ卵母细胞和骨髓细胞均为辐射的敏感指标。骨髓细胞的辐射敏感性高于MⅡ卵母细胞。

 
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