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原位腺癌
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  adenocarcinoma in situ
     Methods Sixty three formalin fixed and paraffin embedded human cervical specimens,including 28 with benign endocervical glands,8 with cevical adenocarcinoma in situ and 27 with cervical adenocarcinomas were exanmined by using the immunochesitry method with polyclonal antibodies that react specifically to TGF β 1,TGF βR 1 and p27kipl.
     方法 :选择 6 3例宫颈标本 ,包括 2 8例良性宫颈内膜腺体 ,8例宫颈原位腺癌和 2 7例宫颈腺癌 ,采用S P方法检测多克隆抗体TGF β1 、TGF β1 受体和单克隆抗体p2 7Kip表达情况。
短句来源
     Invasive cervical adenocarcinoma immediately following a cone biopsy for adenocarcinoma in situ with negative margins
     原位腺癌锥切活检显示边缘阴性与宫颈浸润性腺癌
短句来源
     Pelvic sidewall adenocarcinoma after definitive therapy for cervical adenocarcinoma in situ
     宫颈原位腺癌根治后出现骨盆侧壁腺癌
短句来源
     Results Criteria for histological grading of CIGN into three degrees, grade Ⅰ to Ⅲ, were proposed according to the hyperchromasia and the stratification of nuclei, number of mitoses and the amount of intracellular mucin. Adenocarcinoma in situ was classified as CIGN Ⅲ.
     结果 病理形态学分级标准根据核染色质的增多、核的异型性及细胞内粘液的数量将宫颈腺上皮内肿瘤分为3级 ,宫颈原位腺癌纳入Ⅲ级宫颈腺上皮内肿瘤中 ,其中 4 6.5 3 % ( 4 7/ 10 1)的病例合并鳞状上皮内病变或宫颈原位癌。
短句来源
     Another 2 of them was confirmed as infiltrating adenocarcinoma after conization. There were 3 CIN cases with adenocarcinoma in situ at the same time.
     2例术前活检阴性者锥切术后被证实为浸润性腺癌,另有3例CIN患者同时合并原位腺癌,术后均予再次手术。
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  相似匹配句对
     Adenocarcinoma in situ of the cervix in pre-gnancy
     孕期原位宫颈腺癌
短句来源
     Establishment of orthotopic model of hamster pancreatic cancer and its biologic characteristics
     仓鼠胰腺癌原位模型的建立及生物学特性
短句来源
     Cataract extraction by phacoemulfication in situ
     原位超声乳化白内障吸除术
短句来源
     A DISCUSSION ON IN-SITU COMPOSITES
     原位复合材料
短句来源
     Adenocarcinoma of the Esophagus
     食管腺癌
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  adenocarcinoma in situ
Histologic examination of the surgical specimen revealed in one of the ovaries an adenocarcinoma in situ that had unequivocally developed within a focus of endometriosis.
      
Die Lokalisation des Adenocarcinoma in situ der Cervix uteri
      
Adenocarcinoma in situ coexisting with carcinoma in situ of the cervix during pregnancy
      
The papillary and tubular structures of this "adenocarcinoma in situ" are identical with those of invasive adenocarcinomas.
      
Histologically, the bile duct lesions were divisible into hyperplasia, dysplasia, adenocarcinoma in situ and invasive adenocarcinoma.
      
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Objective: To study the expression of CD44v6 protein in the dysplasia, carcinoma in situ, invasive squamocellular carcinoma and adenocarcinoma of cervix uteri, and the relationship between the expression and the prognosis. Methods: The method of immunohistochemistry was used to study the expression of CD44v6 protein in the cases, including 10 normal cervix, 15 dysplasia, 16 squamocellular carcinoma in situ , 1 adenocarcinoma in situ , 27 invasive squamocellular carcinoma, and 15 invasive adenocarcinoma...

Objective: To study the expression of CD44v6 protein in the dysplasia, carcinoma in situ, invasive squamocellular carcinoma and adenocarcinoma of cervix uteri, and the relationship between the expression and the prognosis. Methods: The method of immunohistochemistry was used to study the expression of CD44v6 protein in the cases, including 10 normal cervix, 15 dysplasia, 16 squamocellular carcinoma in situ , 1 adenocarcinoma in situ , 27 invasive squamocellular carcinoma, and 15 invasive adenocarcinoma of cervix uteri, The results were analyzed semi quantitatively with scanning system. And the data were analyzed statistically. Results: (1) The staining reaction of CD44v6 protein was mainly confined to the cellular membrane. (2) Normal epithelial, cervical dysplasia, squamocellular cervical carcinoma in situ and invasive squamocellular carcinoma showed expression of CD44v6 in 1/10, 7/15, 7/16 and 20/27. (3) In the positive cases of pelvic lymphonodes metastasis in invasive squamocellular carcinoma of cervix, the staining reaction of CD44v6 was stronger than that in the negative cases of metastasis in the same disease ( P =0.006). There is no relationship between the expression of CD44v6 and the FIGO stage and carcinoma cellular grade in this study. Conclusion: The degree of staining reaction of CD44v6 increased in the order of normal cervix, Cervical Intraepithelial neoplasia (CIN) and invasive squamocellular carcinoma of cervix; There is really the relationship between the staining reaction of CD44v6 and pelvic lymphonodes metastasis in invasive squamocellular carcinoma; There is perhaps the relationship between the staining reaction of CD44v6 and poor prognosis of cervix adenocarcinoma, but the degree of this relationship should be studied again in more cases. (J Beijing Med Univ, 2000,32:155 157)

目的 :了解CD44v6在宫颈上皮不典型增生、宫颈原位癌、宫颈浸润鳞癌及腺癌中的表达及其与预后因素的关系。方法 :用免疫组化法检测 10例正常宫颈上皮、15例宫颈上皮不典型增生、16例宫颈原位鳞癌、1例宫颈原位腺癌、2 7例宫颈浸润鳞癌、15例宫颈浸润腺癌中CD44v6蛋白的表达 ,实验结果以图像处理与分析系统进行半定量处理后进行统计分析。结果 :(1)着色部位主要为细胞膜 ,细胞浆不着色或着色较浅。细胞核被苏木素复染成淡蓝色。 (2 )CD44v6阳性表达正常宫颈上皮为 1/ 10 ,宫颈不典型增生为 7/ 15 ;宫颈鳞癌中原位癌为 7/ 16 ,浸润癌为2 0 / 2 7;宫颈腺癌中原位癌 1例CD44v6阴性 ;浸润癌 15例 ,CD44v6阳性表达 2 / 15。 (3)宫颈浸润鳞癌淋巴结转移阳性者CD44v6的灰度显著高于淋巴结转移阴性者 [(0 .30 8± 0 .0 2 1)vs (0 .2 73± 0 .0 31) ,P =0 .0 0 6 ]。CD44v6与宫颈鳞癌的临床分期及细胞分化程度无关。结论 :CD44v6在正常宫颈、CIN、宫颈浸润鳞癌中的阳性表达逐渐增加 ;CD44...

目的 :了解CD44v6在宫颈上皮不典型增生、宫颈原位癌、宫颈浸润鳞癌及腺癌中的表达及其与预后因素的关系。方法 :用免疫组化法检测 10例正常宫颈上皮、15例宫颈上皮不典型增生、16例宫颈原位鳞癌、1例宫颈原位腺癌、2 7例宫颈浸润鳞癌、15例宫颈浸润腺癌中CD44v6蛋白的表达 ,实验结果以图像处理与分析系统进行半定量处理后进行统计分析。结果 :(1)着色部位主要为细胞膜 ,细胞浆不着色或着色较浅。细胞核被苏木素复染成淡蓝色。 (2 )CD44v6阳性表达正常宫颈上皮为 1/ 10 ,宫颈不典型增生为 7/ 15 ;宫颈鳞癌中原位癌为 7/ 16 ,浸润癌为2 0 / 2 7;宫颈腺癌中原位癌 1例CD44v6阴性 ;浸润癌 15例 ,CD44v6阳性表达 2 / 15。 (3)宫颈浸润鳞癌淋巴结转移阳性者CD44v6的灰度显著高于淋巴结转移阴性者 [(0 .30 8± 0 .0 2 1)vs (0 .2 73± 0 .0 31) ,P =0 .0 0 6 ]。CD44v6与宫颈鳞癌的临床分期及细胞分化程度无关。结论 :CD44v6在正常宫颈、CIN、宫颈浸润鳞癌中的阳性表达逐渐增加 ;CD44v6与宫颈鳞癌淋巴结转移相关 ;CD44v6阳性可能与宫颈腺癌的不良预后有关 ,其相关性需进一步研究。

Objective To discuss the histopathology and immunohistochemical expression in precursor lesion of cervical adenocarcinoma cervical intraepithelial glandular neoplasia (CIGN). Methods Histopathological examination and immunohistochemical study (SP method) were performed on 101 cases of CIGN. Results Criteria for histological grading of CIGN into three degrees, grade Ⅰ to Ⅲ, were proposed according to the hyperchromasia and the stratification of nuclei, number of mitoses and the amount of intracellular mucin....

Objective To discuss the histopathology and immunohistochemical expression in precursor lesion of cervical adenocarcinoma cervical intraepithelial glandular neoplasia (CIGN). Methods Histopathological examination and immunohistochemical study (SP method) were performed on 101 cases of CIGN. Results Criteria for histological grading of CIGN into three degrees, grade Ⅰ to Ⅲ, were proposed according to the hyperchromasia and the stratification of nuclei, number of mitoses and the amount of intracellular mucin. Adenocarcinoma in situ was classified as CIGN Ⅲ. 46.53% (47/101) CIGN showed a co existence of CIN (SIL). 45 cases were CEA positive (44.55%) and 38 showed apical and luminal positivity. The positive rate of PCNA was 63.54% and was 100% in CIGN Ⅲ. The positive rate of ER was 81.48% (66/81). The expression of ER was often decreased or missing in certain cases. The positive rate of HPV 6/11 in CIGNⅠ Ⅲ was 34.09% (30/88), 31.82% (28/88), and 3.41% (3/88), respectively. Conclusions Histological grading of CIGN is important. Immunohistochemical staining for CEA?PCNA and ER may be helpful in diagnosis and differential diagnosis of CIGN.

目的 探讨宫颈腺癌前驱病变的诊断和鉴别诊断。方法 对 10 1例病理诊断为宫颈腺癌前驱病变 宫颈腺上皮内肿瘤的标本进行病理形态学观察 ,同时采用免疫组织化学SP法进行癌胚抗原 (CEA)、增殖细胞核抗原 (PCNA)、雌激素受体 (ER)及人乳头瘤病毒 (HPV6/ 11)的检测。结果 病理形态学分级标准根据核染色质的增多、核的异型性及细胞内粘液的数量将宫颈腺上皮内肿瘤分为3级 ,宫颈原位腺癌纳入Ⅲ级宫颈腺上皮内肿瘤中 ,其中 4 6.5 3 % ( 4 7/ 10 1)的病例合并鳞状上皮内病变或宫颈原位癌。免疫组织化学检测结果 :CEA阳性率为 4 4 .5 5 % ( 4 5 / 10 1) ,此外 3 7.62 % ( 3 8/ 10 1)阳性部位表浅 ,仅局限于细胞的顶端及腔缘 ;PCNA强阳性率为 63 .5 4 % ( 61/ 96) ,在Ⅲ级宫颈腺上皮内肿瘤中全部呈强阳性表达 ;ER阳性率为 81.4 8% ( 66/ 81) ,但在部分阳性病例中ER不是均匀分布 ,仅局限阳性 ;HPV6/ 11在Ⅰ~Ⅲ级宫颈腺上皮内肿瘤中的检出率分别为 3 4 .0 9% ( 3 0 / 88)、...

目的 探讨宫颈腺癌前驱病变的诊断和鉴别诊断。方法 对 10 1例病理诊断为宫颈腺癌前驱病变 宫颈腺上皮内肿瘤的标本进行病理形态学观察 ,同时采用免疫组织化学SP法进行癌胚抗原 (CEA)、增殖细胞核抗原 (PCNA)、雌激素受体 (ER)及人乳头瘤病毒 (HPV6/ 11)的检测。结果 病理形态学分级标准根据核染色质的增多、核的异型性及细胞内粘液的数量将宫颈腺上皮内肿瘤分为3级 ,宫颈原位腺癌纳入Ⅲ级宫颈腺上皮内肿瘤中 ,其中 4 6.5 3 % ( 4 7/ 10 1)的病例合并鳞状上皮内病变或宫颈原位癌。免疫组织化学检测结果 :CEA阳性率为 4 4 .5 5 % ( 4 5 / 10 1) ,此外 3 7.62 % ( 3 8/ 10 1)阳性部位表浅 ,仅局限于细胞的顶端及腔缘 ;PCNA强阳性率为 63 .5 4 % ( 61/ 96) ,在Ⅲ级宫颈腺上皮内肿瘤中全部呈强阳性表达 ;ER阳性率为 81.4 8% ( 66/ 81) ,但在部分阳性病例中ER不是均匀分布 ,仅局限阳性 ;HPV6/ 11在Ⅰ~Ⅲ级宫颈腺上皮内肿瘤中的检出率分别为 3 4 .0 9% ( 3 0 / 88)、3 1.82 % ( 2 8/ 88)和 3 .4 1% ( 3 / 88)。结论 宫颈腺上皮内肿瘤的病理组织学分级具有重要的临床意义 ,CEA、PCNA及ER等免疫组织化学表达在诊断及鉴别诊断中具有一定的参考价值。

Objective To investigate the relationship between the expression of the TGF β 1 ligands and TGF β 1 receptors with the expression of p27kipl in cervical cancer.Methods Sixty three formalin fixed and paraffin embedded human cervical specimens,including 28 with benign endocervical glands,8 with cevical adenocarcinoma in situ and 27 with cervical adenocarcinomas were exanmined by using the immunochesitry method with polyclonal antibodies that react specifically to TGF β 1,TGF βR 1 and p27kipl.Results...

Objective To investigate the relationship between the expression of the TGF β 1 ligands and TGF β 1 receptors with the expression of p27kipl in cervical cancer.Methods Sixty three formalin fixed and paraffin embedded human cervical specimens,including 28 with benign endocervical glands,8 with cevical adenocarcinoma in situ and 27 with cervical adenocarcinomas were exanmined by using the immunochesitry method with polyclonal antibodies that react specifically to TGF β 1,TGF βR 1 and p27kipl.Results In normal endocervix,the TGF β 1 showed weak cytoplasmic staining,while p27kipl1 showed strong nuclear staing.High expression of TGF β 1 ligand and leceptor was observed as tumor upgrading,expression of TGF β 1 was lower in adenocarcinoma than that in adenocarcinoma in situ,but still significantly higher than that in normal endocervix.p27kipl protein expression decreased,while normal endocervix showed the highest level of p27kipl protein expression.Conclusions Neoplastic transformation of the cervix may be related to dysregulation of TGF β 1 and p27kipl.

目的 :研究p2 7Kip在宫颈癌中的表达与TGF β1 配体和TGF β1 受体表达之间的关系。方法 :选择 6 3例宫颈标本 ,包括 2 8例良性宫颈内膜腺体 ,8例宫颈原位腺癌和 2 7例宫颈腺癌 ,采用S P方法检测多克隆抗体TGF β1 、TGF β1 受体和单克隆抗体p2 7Kip表达情况。结果 :正常的子宫颈内膜标本中 ,TGF β1 显示出弱的胞质染色 ,而p2 7Kip显示胞核强阳性 ,与正常宫颈组织相比 ,随着肿瘤恶性程度的增加 ,TGF β1 配体和TGF β1 受体胞质染色随之增强。在腺癌中TGF β1 的表达比原位宫颈癌中表达变弱 ,但比正常的子宫内膜仍有显著性增强 ,p2 7Kip蛋白的表达随着肿瘤恶性程度增加而下降 ,而正常的子宫内膜则显示出最强的p2 7Kip蛋白的表达。结论 :子宫内膜的肿瘤转化可能与TGF β1 和p2 7Kip的异常表达有关

 
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