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腺癌增殖
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  cancer proliferation
     Pancreatic cancer proliferation cell nuclear antigen(PCNA)was also tested as the index of the extent of proliferation of the pancreatic cancer.
     同时,检测胰腺癌增殖细胞核抗原(PCNA)作为胰腺癌增殖状态的指标。
短句来源
     Pancreatic cancer proliferation cell nuclear antigen (PCNA) was also tested as the index of the extent of proliferation of the pancreatic cancer.
     同时检测胰腺癌增殖细胞核抗原(PCNA),作为胰腺癌增殖状态的指标。
短句来源
  “腺癌增殖”译为未确定词的双语例句
     Expression of CD_(44)v6 in Human Pancreatic Cancer
     CD_(44)v6表达与胰腺癌增殖、转移及预后关系的研究
短句来源
     Objective To study the relationship between the hyperplasis, lymph node metastasis, prognosis and the expression of CD44v6 in human pancreatic carcinoma.
     目的 探讨CD44v6蛋白表达与胰腺癌增殖及淋巴结转移的关系。
短句来源
     The Relation between the Expression of Hypoxia-inducible Factor-1 Alpha and Apoptosis and Proliferation in Pancreatic Cancer
     缺氧诱导因子-1α的表达与胰腺癌增殖和凋亡关系的研究
短句来源
     EXPRESSION OF HYPOXIA-INDUCIBLE FACTOR-1 ALPHA AND APOPTOSIS AND PROLIFERATION IN PANCREATIC CANCER
     低氧诱导因子-1α表达与胰腺癌增殖和凋亡的关系
短句来源
     Meanwhile, with the increasing expression of mutant p53 protein, PCNA expression is in creased, indicating that tumor with p53 mutation is higher proliferative activity and the adenocarcinoma is the highest in all tumors.
     结论 :p53突变可能通过抑制细胞凋亡促进大肠癌的形成 ,而当突变型p53蛋白表达增加时 ,PCNA表达亦增加 ,提示p53突变的肿瘤具有较高的增殖活性 ,其中腺癌增殖程度最高。
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  相似匹配句对
     A study of proliferating cell nuclear antigen /cyclin in adenocarcinoma of endometrium
     子宫内膜腺癌增殖细胞核抗原的研究
短句来源
     Proliferating Cell Neuclear Antigen(PCNA) Expression in Gastric and Colorectal Adenocarcinoma
     胃肠腺癌增殖细胞核抗原表达及意义
短句来源
     Adenocarcinoma of the Esophagus
     食管腺癌
短句来源
     X.
     X上的增殖算子。
短句来源
     BARRETT'S ADENOCARCINOMA
     Barrett食道腺癌
短句来源
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  cancer proliferation
A VIP hybrid antagonist (neurotensin6-11 VIP7-28) that has been shown to inhibit lung cancer proliferation was now tested for inhibition of neuroblastoma growth.
      
Wild-type p16 inhibited prostate-cancer proliferation in vitro and markedly suppressed tumors in vivo.
      
We investigated a possible relationship between brefeldin A (BFA), an antibiotic, and cathepsin D (Cat.D), a lysosomal protease, in prostate cancer proliferation.
      
Therefore, BFA-induced growth inhibition in prostatic cancer cells is associated with a blocking of Cat.D maturation (activation), suggesting a possible role of Cat.D in prostate cancer proliferation/development.
      
Matrix metalloproteinases (MMPs), a family of zinc-binding endopeptidases, play important roles in cancer proliferation and dissemination, and may be further associated with other diseases.
      
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In order to explore the relationship of signal transductive effects of Laminin(Ln) onproliferation of mouse lung metastatic neoplasm. In vitro, effects of exopenous LA(exLn), antibody of Ln(Ln - Ab)and phorbol - 12 - myristate - 13 - acetate(PMA, protein kinase C(PKC) agonist) on the Proliferation of twocloned sttalns(C6/C7) were compared in an in vitro experiment. Both metastasis and endogenous Ln(enLn)expression were much higher in C6 cell than in C7 cell. Result: C6 cell possessal higher proliferative potentialthan...

In order to explore the relationship of signal transductive effects of Laminin(Ln) onproliferation of mouse lung metastatic neoplasm. In vitro, effects of exopenous LA(exLn), antibody of Ln(Ln - Ab)and phorbol - 12 - myristate - 13 - acetate(PMA, protein kinase C(PKC) agonist) on the Proliferation of twocloned sttalns(C6/C7) were compared in an in vitro experiment. Both metastasis and endogenous Ln(enLn)expression were much higher in C6 cell than in C7 cell. Result: C6 cell possessal higher proliferative potentialthan C7 cell which was further increased by the aetion of exLn, and showed besides exLn in combination withPMA the synergistic action. The contrary, by the action of Ln- Ab, the Proliferation of C7 cell was decreaseddecmuch more than that of C6 cell. By the action of PMA alone, the proliferation of C6 cell was decreased muchmere than that of C7 cell and homeostasis of calcium ion across the plasma inelnblane(Ca2+ APM) of C6 cellwas also ehanged. Conclusion: The proliferation of the mouse long adenocarcinoma cells with low and highmetastasis were correlated to signal transductive effect of Ln, which might be related to the variation of bothPKC activity and Ca2 + APM homeostasis.

为了揭示层粘连蛋白(laminin,Ln)信号传递作用与转移性肺腺癌增殖的关系。体外以外源性Ln(exogenousLn,exLn),抗Ln抗体(antibodyofLn,Ln-Ab)以及PMA[phorbol-12-myristate-13-acetate,蛋白激酶C(PKC)激活剂]作用于小鼠肺腺癌内源性Ln(endogenousLn,enLn)高表达的高转移克隆化正系(C6)及其低表达的低转移克隆化正系(C7)进行比较研究。结果:exLn能使C6细胞比C7细胞的增殖力在已是较高水平的基础上进一步提高,并与PMA的共同作用显示了增殖效应的协同。相反,Ln-Ab能使C7细胞比C6细胞的增殖力获得更明显抑制;并且,仅PMA的作用却使C6细胞比C7细胞的增殖力呈现更明显的抑制,并使C6细胞的跨膜Ca2+流恒态(homeostasis)发生显著性改变。结论:层粘连蛋白信号传递作用与高、低转移性小鼠肺腺癌细胞的增殖密切相关,这可能与PKC活性及跨膜Ca2+流恒态的变化相互关联.

The expression of bcl 2 and P 16 in 24 cases of gallbladder mucosa hyperplasia and 38 cases of gallbladder carcinoma was detected by immunohistochemical staining.Normal gallbladder mucosa was uniformly negative.bcl 2 and P 16 positive rate was significantly higher in hyperplasia and carcinoma than in normal tissue (P<0 01).Expression of bcl 2 and P 16 got higher with the increasing degree of hyperplasia,P 16 was related to lymph node metastasis.The study suggested that bcl 2 may have...

The expression of bcl 2 and P 16 in 24 cases of gallbladder mucosa hyperplasia and 38 cases of gallbladder carcinoma was detected by immunohistochemical staining.Normal gallbladder mucosa was uniformly negative.bcl 2 and P 16 positive rate was significantly higher in hyperplasia and carcinoma than in normal tissue (P<0 01).Expression of bcl 2 and P 16 got higher with the increasing degree of hyperplasia,P 16 was related to lymph node metastasis.The study suggested that bcl 2 may have some significance for gallbladder adenocarcinoma developing sequence.P 16 expression plays an important role in tumorigenesis and cancerization.bcl 2 and P 16 may be used as a good marker relating to cell apoptosis.

用免疫组化方法观察24例胆囊粘膜异型增生和38例胆囊腺癌中bcl-2和P16蛋白的表达。结果显示:正常胆囊粘膜中bcl-2和P16均未见表达,而胆囊粘膜上皮异型增生及胆囊腺癌阳性率较正常组织明显增加(P<0.01),bcl-2和P16蛋白的阳性率也随着异型增生程度增加而增高。P16表达与胆囊腺癌淋巴结转移有关。结果表明,bcl-2蛋白表达对胆囊腺癌的增殖有一定意义,P16在胆囊粘膜癌变和胆囊腺癌进展中起重要作用。

Objective To study the expression of proliferating cell nuclear antigen(PCNA) in serous and mucinous carcinoma of the ovary and its correlation with clinicopathology,lymph node metastasis and patient's prognosis. Methods An immunohistochemical study on 50 cases with serous carcinoma of the ovary,18 cases with mucinous carcinoma of the ovary and 5 specimens with normal ovary tissue by using PC 10 ,a monoclonal antibody against-proliferating cell nuclear antigen(PCNA)was performed on paraffin sections and...

Objective To study the expression of proliferating cell nuclear antigen(PCNA) in serous and mucinous carcinoma of the ovary and its correlation with clinicopathology,lymph node metastasis and patient's prognosis. Methods An immunohistochemical study on 50 cases with serous carcinoma of the ovary,18 cases with mucinous carcinoma of the ovary and 5 specimens with normal ovary tissue by using PC 10 ,a monoclonal antibody against-proliferating cell nuclear antigen(PCNA)was performed on paraffin sections and analysed. Results PCNA scores in serous carcinoma of the ovary were significantly higher than that in mucinous carcinoma of the ovary( P <0.005).There were significant difference statistically in PCNA scores between any two of the three groups of the tumor grade analysed( P <0.05 or P <0.02).PCNA scores in advanced ovarian carcinoma(stage Ⅲ Ⅳ)were significantly higher than that in early ovarian carcinoma (stage Ⅰ Ⅱ)( P <0.005).Higher scores of PCNA positive staining were found in ovarian carcinoma with lymph node metastasis than that in without lymph node metastasis ( P <0.02).There was a significant difference in survival between patients with high PCNA index(≥51%)and low index (≤10%)( P <0.05). Conclusion:PCNA immnostaining may be used as a new method to assess the patient's prognosis and lymph node involvement of serous and mucinous carcinoma of the ovary.

目的:研究卵巢浆、粘液性囊腺癌增殖细胞核抗原(PCNA)的表达及其临床病理意义。方法:应用PCNA的单克隆抗体PC10,以ABC免疫组织化学方法,对50份卵巢浆液性囊腺癌、18份卵巢粘液性囊腺癌和5份正常卵巢组织的石蜡标本作PCNA表达的检测,并根据其阳性细胞率评分。结果:卵巢浆液性囊腺癌PCNA阳性细胞率评分高于卵巢粘液性囊腺癌;组织学分化程度越低,PCNA阳性细胞率评分越高;临床分期越晚,PC-NA阳性细胞率评分越高;伴有淋巴转移者PCNA阳性细胞率评分高于无淋巴转移者;PCNA表达为强级的患者5a生存率明显低于PCNA表达为弱级者;差异均有显著性。结论:PCNA免疫组化检测可作为预测卵巢浆、粘液性囊腺癌淋巴转移和患者预后的重要参考指标。

 
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