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剂量-抑制
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  dose-inhibition
     For the relations of dose-inhibition rate, the cubic curves also have best fitness and their R2 is 0.998~1.000 greater than the R2 0.948~0.987 of linear model of logarithm dose-probit.
     3种药物对 2种细胞的剂量 -抑制率以三次项曲线拟合度最好 ,r2 为0 998~ 1 0 0 0 ,优于对数剂量 -概率单位线性模型的r20 94 8~ 0 987。
短句来源
     AIM We found in experiment that the relation of cell number-OD in MTS cytotoxicity assay is non-linearity. In this paper we probe into the relations of cell number-OD and drug dose-inhibition rate.
     目的 探讨MTS法细胞毒试验的细胞数 OD关系以及药物剂量 -抑制率关系 ,为更好地应用MTS法提供提示。
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  “剂量-抑制”译为未确定词的双语例句
     A more accurate IC 50 would be obtained by the cubic curve equation than by probit regression that is in common use.
     通过药物剂量 -抑制率的三次项曲线拟合方程可望得到比常用的概率单位回归法更准确的IC50 。
短句来源
  相似匹配句对
     The inhibitions were dosedependent.
     该抑制剂量依赖性。
短句来源
     Inhibition
     抑制
短句来源
     middle dose inhibitory peptide group;
     中剂量抑制肽组 ;
短句来源
     inhibit the apoptosis;
     抑制细胞凋亡;
短句来源
     The effects of different dosages of granulocyte colony stimulating factor in the treatment of chemotherapyinduced myelosuppression of acute lymphoblastic leukemia
     不同剂量G-CSF在急性淋巴细胞白血病化疗抑制期的疗效观察
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  dose-inhibition
Dose-inhibition curves were determined for DFEN, PHEN, and TNIX alone and for fixed ratio combinations of DFEN with either PHEN or TNIX.
      
Results: Each drug produced a near linear dose-inhibition curve with the 50% inhibitory doses (DI50) of 5.6, 3.2 and 12.2?mg/kg, respectively.
      
Using an experimental protocol avoiding the run-down ghe dose-inhibition curve for ATP was found to reach 50% at 18 μM.
      
Dose-inhibition curves showed that glibenclamide added for 48 hr reduced cell growth at concentrations as low as 1 μm (IC50= 73 μm) when growth was assayed in the absence of added serum.
      
When the highest inhibition rate in dose-inhibition curve was equal to or greater than 50%, the tumor was regarded to be sensitive to the agent.
      
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This study demonstrated that the monolayer culture of rat pituitary gland could be established and that dopamine and bromo ?criptine had direct inhibitory effects on rat pituitary secretion of prolactin. Different concentrations had different inhibitory effects. The results of bioassay were much higher than RIA. T RH stimulated the production of prolactin by rat pituitary cells in culture. Almost the same stimulation was observed with different concentration of TRH.

大鼠垂体前叶的单层细胞培养可以建立。不同剂量的多巴胺(Dopamine)与溴隐亭(Bromocriptine,CB~(154))对大鼠垂体前叶分泌催乳素均有抑制作用,不同剂量抑制作用亦有差异,而生物学检定法与放射免疫测定法的结果不一致,前者比后者高一至二倍。促甲状腺激素释放激素(TRH)对大鼠垂体前叶催乳素的分泌有明显刺激作用,而不同浓度TRH的作用差别不大。

Peak ⅠⅡⅢ and Ⅳ were obtained by gel filtration of bee venom on Sephadex C-50F. LD50 of bee venom in mice was 4.32 mg/kg i. p. (3.91-4.76mg/kg). Bee venom significantly inhibited the nociceptive response of mice to electric stimunation. The inhibiting rate of 2.16 mg/kg and 1.44 mg/kg were 90% and 55% respectively. There was a good relationship between dose and response or time and response for analgetic action of bee venom. ED60 for bee venom was l.20mg/kg. The analgetic action occured within 1hr, rearched a...

Peak ⅠⅡⅢ and Ⅳ were obtained by gel filtration of bee venom on Sephadex C-50F. LD50 of bee venom in mice was 4.32 mg/kg i. p. (3.91-4.76mg/kg). Bee venom significantly inhibited the nociceptive response of mice to electric stimunation. The inhibiting rate of 2.16 mg/kg and 1.44 mg/kg were 90% and 55% respectively. There was a good relationship between dose and response or time and response for analgetic action of bee venom. ED60 for bee venom was l.20mg/kg. The analgetic action occured within 1hr, rearched a peak in 5 hrs and persisted 12-48hrs for bee venom. Bee venom also exhibited antiinflammatory and antipyretic activity.

采用sephadex G-50F柱层析及CM-sephadex C-50离子交换柱梯度洗脱法,从峰毒中分出Ⅰ、Ⅱ、Ⅲ及Ⅳ组分。 全峰毒对小白鼠的LD50为4.32mg/kg(3.91~4.76mg/kg)。全蜂毒对电刺激小白鼠的痛嘶叫反应有明显的抑制作用,2.16mg/kg剂量抑制率达90%(P<0.05),1.44mg/kg的为55%。全蜂毒及组分Ⅱ的镇痛作用有明显的量—效关系及时—效关系。以小鼠热板法测定的全蜂毒的ED50为1.20mg/kg;组分Ⅱ为1.02mg/kg。1小时起效,5小时达高峰,持续12~48小时。但组分Ⅱ的作用时间较短。全蜂毒明显抑制致炎剂引起的炎症反应(P<0.001)。此作用有量效关系。同时,亦明显抑制化学性致热反应。

The effects of tranquilizers on the operant behavior in rats were studied by using the microcomputer-controlled operant apparatus, made by our experimental workshop.A minor tranquilizer flurazepam and three major tranquilizers chlorpromazine,clozapine, and sulpiride were selected to observe their effects on fixed ratio schedule-controlled behavior in rats.In small doses not affecting the locomotor activity, these tranquilizers promoted the press-lever response in rats. Large doses of these drugs depressed the...

The effects of tranquilizers on the operant behavior in rats were studied by using the microcomputer-controlled operant apparatus, made by our experimental workshop.A minor tranquilizer flurazepam and three major tranquilizers chlorpromazine,clozapine, and sulpiride were selected to observe their effects on fixed ratio schedule-controlled behavior in rats.In small doses not affecting the locomotor activity, these tranquilizers promoted the press-lever response in rats. Large doses of these drugs depressed the press-lever response and the depressive effect was dose-dependent.Our conclusion is that tranquilizers have both promoting and depressing effects on operant behavior, depending upon the dosage used, and the promoting effect is not relate to the effect on the locomotor activity.

使用我院研制的国产第一台电脑控制的大鼠操作性条件反射仪观察宁静剂:氟安定(flurazepam)、氯丙嗪、氯氮平(clozapine)、舒必利(sulpiride)对大鼠固定比率操作行为(operant behavior)的影响。这些宁静剂对大鼠操作行为具有双相作用,小剂量促进压杆操作行为,大剂量抑制操作反应。这一作用具有剂量依赖性,它们对操作行为的影响与它们对活动性影响之间没有平行关系。

 
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