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  epithelium (
     2. Survivin/ actin ratio(0.6169 0.2294) and survivin mRNA positive rate(78.8%) in esophageal carcinoma were both significantly higher than those in normal epithelium(0.2338 0.1810, 21.2%).
     2.食管癌中survivin mRNA表达强度为0.6169±0.2294,阳性率为78.8%,明显高于食管正常粘膜(0.2338±0.1810,21.2%);
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     Results The positive expression rate of β1 integrin in esophageal squamous cell carcinoma(61.67%)was lower than that in normal mucosa epithelium(90.00%),but there was no significant difference between them(P>0.05).
     结果β1整合素在食管鳞癌中的阳性表达率(61.67%)较正常粘膜(90.00%)低,但无显著性差异(P>0.05);
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     3. pSS1 protein showed 50.8% positive expressions in esophageal carcinoma, which were significantly lower than those in normal epithelium(96.7%).
     3.食管癌中p33取G1蛋白表达的阳性信号定位于胞浆,阳性率为50.8%,明显低于食管正常粘膜(96.7%);
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     Method:PCR-based restriction enzyme assay and immunohistochemical SP technique were used to detect the status of methylation of FHIT gene promoter and expression of its protein in 41 cases of LSCC and their matched normal squamous epithelium (NSE).
     方法:采用PCRbased酶切甲基化及免疫组织化学SP技术,检测41例LSCC及其相对应的喉正常粘膜(NSE)中FHIT基因启动子甲基化状态及其蛋白表达。
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     1. Survivin protein showed 82.2% positive expressions in esophageal carcinoma, which were significantly higher than those in normal epithelium(22.3%). Survivin positive staining in carcinoma was located in cytoplasm, or both in cytoplasm and nucleus.
     1.食管癌中survivin蛋白表达的阳性信号主要定位于胞浆,也可胞浆、胞核同时着色,阳性率为82.2%,明显高于食管正常粘膜(22.3%);
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     RESULTS The frequence of H.pylori infection in GC and precancerous lesions(IM 61.7%,Dys 63.3%,GC 42.3%) was significantly higher than that of control normal gastric mucosa(17.5%,P<0.05).
     结果胃癌及癌前病变组织中 H.pylori 的感染率(IM61.7%,Dys 63.3%,GC 42.3%)显著高于正常胃粘膜(17.5%,P<0.05).
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     【Results】Positive rate of MMP9 expression in the colorectal cancer specimens was 84.3%,which was significantly higher than that in the normal mucosa(20.0%,P<0.01),adenomas(26.7%,P<0.01).
     【结果】51例大肠癌MMP9阳性率84.3%,明显高于正常肠粘膜(20.0%)和肠腺瘤(26.7%)(P<0.05和P<0.01);
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     Results The expression of Cks1 and Skp2 in gastric cancers was higher than that in normal gastric tissue(χ2=22.69, Ρ<0.05;χ2=13.42, Ρ<0.05 respectively). While the expression of p27Kip1 was lower than that in normal gastric tissue(χ2=14.83,P<0.05).
     结果胃癌组织中Cks1、Skp2表达明显高于正常胃粘膜(χ2=22.69,P<0.05;χ2=13.42,P<0.05),而p27Kip1表达则低于正常胃粘膜(χ2=14.83,P<0.05)。
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     RESULTS The number of S100+ (0.6 μm2±0.2 μm2) and HLA-DR+ (0.9 μm2±0.2 μm2) cells in gastric mucosa was significantly higher in patients with GC, CAG, Dys and IM than in normal control group (P<0.05).
     结果 胃癌患者胃粘膜中S-100~+(0.6±0.2)μm~2,HLA-DR~+(0.9±0.2)细胞数量明显多于正常胃粘膜(P<0.05);
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     while the Skp2 mRNA expression was 0. 2791 ±0. 1829 and 0. 7691 ±0. 2514 in the GC tissue and normal gastric mucosa, which showed a stastic significance(t=—10.212 P=0. 0009).
     Skp2在正常胃粘膜和胃癌组织中的mRNA表达指数分别为0.2791±0.1829,0.7691±0.2514,经统计学检验,Skp2在胃癌组织中的表达高于正常胃粘膜(t=-10.212,P=-0.0009);
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     In the superficial layer of the mucosa .
     在胃粘膜表层.
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     intra epithelial cells exhibite apoptosis;
     粘膜上皮凋亡;
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  epithelium (
Since first described in 1982, intraductal papillary mucinous neoplasm (IPMN) has been the preferred term to describe the proliferation of the pancreatic ductal epithelium.
      
It was demonstrated that this protein is located extracellularly in the epithelium of mammary ducts, and that this regulatory protein is present in an active form in whole milk; however, it was detectable neither in dry milk nor in infant formula.
      
Histological Characteristics of Age-Related Changes of Spermatogenic Epithelium
      
The data characterizing the age-related morphological changes in the spermatogenic epithelium of SAMP1 (senescence-accelerated prone) and SAMR1 (senescence-accelerated resistant) mice are presented.
      
At this stage, destructive processes in the spermatogenic epithelium were more pronounced in SAMR1 mice.
      
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1. The present study includes observations on the morphology and life history of Haplorchis pumilio (Looss, 1896).2. The opinion of the present writer is to the contrary that skin glands of the metacercaria and adult can be used as a taxonomic character. The spines on the oral sucker of the cercaria are studied in detail and compared with observations made elsewhere.3. The size of the organs and their relative positions are closely related to the age of parasite and errors in calling old species of the genus...

1. The present study includes observations on the morphology and life history of Haplorchis pumilio (Looss, 1896).2. The opinion of the present writer is to the contrary that skin glands of the metacercaria and adult can be used as a taxonomic character. The spines on the oral sucker of the cercaria are studied in detail and compared with observations made elsewhere.3. The size of the organs and their relative positions are closely related to the age of parasite and errors in calling old species of the genus Haplorchis as new are due to overlooking of this fact.4. In contrary to the opinion of Africa who believed that visceral heterophycidiasis was due to abnormal relationship between host and parasite, the writer believes that those heterophyids which are not normal parasites to a particular host will be expelled instead, and only those which are normal to the host can bury deep in the mucosa, such as Haplorchis, and thus fause visceral heterophyidiasis.5. In view of the wide-spread habit of eating raw fish in Kwangtung Province, the writer believes that Haplorchis infection in man undoubtedly exists.

1.本实验对钩棘单睾吸虫(成虫、囊蚴、雷蚴、尾蚴)的形态及生活史作了详细的观察。 2.小榄白鲩鱼鳍上钩棘单睾囊蚴的感染率及感染强度都比较高。根据囊蚴的寄生状况,广东人对鱼类食品的烹调特点,文献中所记载的异形吸虫的致病作用以及在广州或其附近发现过异形吸虫的报告,估计广东居民中可能有异形吸虫病的存在,并推考了其所以未被发现的原因。 3.钩棘单睾囊蚴、成虫的腹面及背面都有皮腺。囊蚴腹面皮腺的总数及皮腺行数都不恒定,而各行之皮腺数也大多没有规则。 4.由小鸭及小白鼠中钩棘单睾成虫的寄生状态可知该吸虫在这两种小动物体中比较适宜的寄生部位是迴肠下段。寄生部位较深的成虫并无死亡的或发育不良的,所见到之死亡成虫绝大多数是混在排泄物中,也有少数见于粘膜表面。根据寄生虫一般的生活规律及本突验所见之寄生现象,对Africa氏等所述关于异形吸虫和宿主间平衡关系的问题进行了商讨。 5.在小白鼠的突验中发现感染天数不同的成虫,它们的虫体及生殖器官的大小可以有相当明显的差别。各器官和虫体前端间的相对距离可因成熟度和活动度不同而有比较显著的差异,尤以生殖器官为甚。本文对Kobayasi氏所定“新种”的根据进行了讨论。

~~

先后在21名健康人及1名一侧大脑皮層全切除的病人身上,用酸刺激一侧口腔粘膜,記录两侧腮腺分泌的方法,研究了唾液分泌非条件反射的特性,其阳性与阴性条件反射的建立以及其皮層代表区的部位。获得如下結果: (一)人两側腮腺分泌反射在口腔中的感受面基本上是分开的,以酸刺激一側口腔粘膜主要地引起同侧腮腺的活动。 (二)以酸刺激一侧口腔粘膜为非条件反射,可以建立該側腮腺活动的条件反射,并且还可建立此条件反射的分化。 (三)以两个中性动因分别与两側腮腺的非条件反射活动相結合,則該两动因可分別成为两側腮腺活动的条件刺激物。 (四)人类每側腮腺分泌反射的皮層代表区在同側大脑皮層。

Having examined the sectioned and stained brain material of the representatives ofthe main orders of the mammalian class, I recognize three routes by which the mesen-cephalic nucleus of the trigeminal nerve in the broad sense is connected to the cerebellum. Through the anterior medullary velum, these sensory ganglionic cells attain to thecerebellar basis, the roof plate of the fourth ventricle, the fastigial nucleus and the cortexof the nodulus. Rostrally the cells of this nucleus are deeply stationed in the...

Having examined the sectioned and stained brain material of the representatives ofthe main orders of the mammalian class, I recognize three routes by which the mesen-cephalic nucleus of the trigeminal nerve in the broad sense is connected to the cerebellum. Through the anterior medullary velum, these sensory ganglionic cells attain to thecerebellar basis, the roof plate of the fourth ventricle, the fastigial nucleus and the cortexof the nodulus. Rostrally the cells of this nucleus are deeply stationed in the side-wall of the fourthventricle; their central processes course posteriorly along the outer margin of the centralgray matter. The fibers from the main nucleus sweep dorsally around into the fastigialnucleus and the cerebellar medulla; and a few sensory cells strewn along this route. Suchsensory cells may also migrate into the cerebellum in company with the nucleus coeruleusand possibly also with the brachium conjunctivum. Through the medial, lateral and possibly superior vestibular nuclei the cells of themesencephalic nucleus are scattered along to the cerebellum, its dentate nucleus in parti-cular. Besides the trigeminal nerve, the mesencephalic nucleus is also related to the oculo-motor, trochlear, abducent, facial, glossopharyngeal and vagal nerves, their motor nucleiand the reticular formation of the medulla oblongata. It is neither affiliated specifically tothe trigeminus nor confined to the midbrain. The "mesencephalic nucleus of the trige-minus" is thus a long misnomer. Collectively it is a rarefied group of primary sensorycells oddly inclosed in the central nervous system. These centrally situated sensory cells conduct proprioceptive and exteroceptive impu-lses chiefly from the jaw muscles and the associated skin and mucous membrane. Theirconnections with the cerebellum afford the latter with the necessary afferent data for itscoordination of the feeding activity in progress. Besides, these sensory cells are appar-ently concerned also with the regulation of the movements of the eye, ear, nose, mouth,pharynx and larynx and possibly of the neck. There exist on the cerebellar cortex proprioceptive and exteroceptive projection fieldsfor the head region; this physiological finding gains some morphological support fromwhat has been elucidated in the present study.

我观察了哺乳纲主要各目的代表动物的脑切片,认定广义的三叉神经中脑核由三个路线连接小脑。这群感觉细胞通过前髓帆到达小脑基部、第四脑室的顶板,顶核以及蚓小结的皮貭。在上端,中脑核细胞深在第四脑室的旁壁;它们的中枢突起靠中央灰貭外缘纵行向后伸展。有些细胞可随着蓝斑、也可能连同结合臂进入小脑。中脑核主部的纤维经脑室旁壁向背侧弯行,直入顶核和小脑的髓貭;也有少数细胞沿此路綫散在。中脑核细胞可经前庭内侧、外侧和(可能)上核散入小脑,特是齿状核。除三叉神经外,中脑核细胞也连接动眼、滑车、外展、面、舌咽和迷走神经,它们的运动(和感觉)核团,以及延髓的网状结构。据此,“三叉神经中脑核”是一个误称。它不专属三叉神经,也不局于中脑地区。它实是散处脑干内部的一群一级的感觉细胞。这一系感觉细胞传导自受的和外受的神经冲动,这起于咀咬肌和连属的皮肤和粘膜。它们连接小脑,供给它必要的求心资料,以便它协调正在执行的进食动作。此外,它们似也调节眼肌、面肌、咽喉肌、甚至颈肌的运动。小脑皮质上有头颈部的自受和外受系的投射地区;本文阐述的事实给这个生理的发现若干形态的根据。

 
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