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生物利用度     
相关语句
  bioavailability
    STUDIES ON BIOAVAILABILITY AND PHARMACOKINETIC PARAMETERS OF SODIUM PHENYTOIN TABLET IN HUMAN BY RADIOIMMUNOASSAY METHOD
    用放射免疫分析法研究苯妥英钠片剂在人体内的生物利用度和药物动力学参数
短句来源
    STUDIES ON THE BIOAVAILABILITY OF SULFAMETHOXAZOLE TABLETS 2.Investigation of Sulfamethoxazole Tablets Release Standands
    新诺明片生物利用度的研究——2.新诺明片释放度质量标准
短句来源
    STUDY ON THE BIOAVAILABILITY AND PHARMACOKINETICS FOR 10% ACETAMINOPHEN INJECTION
    10%朴热息痛注射液的生物利用度及药物动力学研究
短句来源
    PARAMETERS OF BIOAVAILABILITY, T(P)AND C(P), CALCULATED BY REGRESSION OF A CONIC FITTING
    二次曲线回归拟合计算生物利用度参数t_p c_p值
短句来源
    Preparation of Piroxicam β-Cyclodextrin Inclusion Compound and Its Bioavailability in Rabbits
    吡罗昔康β-环糊精包合物的制备及兔体内生物利用度研究
短句来源
更多       
  biological availability
    Just like other nitromidazole drugs,secnidazole has the antimicrobial activity. It can be absorbed orally,and its biological availability is (100±26)%. With secnidazole at a single 0.5~2g dose orally, C max is 35.7~46.3mg·L -1 ,the T max is 1.42~3h, t 1/2 β is 17~29h.
    塞克硝唑与其他硝基咪唑类药物一样具有抗原生虫的生物活性 ,口服吸收良好 ,生物利用度为 (1 0 0± 2 6) % ,单剂量口服塞克硝唑 0 .5~ 2 g ,Cmax为 35 .7~ 46 .3mg·L- 1 ,Tmax为 1 .42~3h ,消除半衰期 (t1 /2 β)为 1 7~ 2 9h。
短句来源
    Study on Biological Availability of Magnesium Valprote Extended Action Tablet
    稳态试验丙戊酸镁缓释片人体生物利用度的研究
短句来源
  relative bioavailability
    Pharmacokinetic characteristics and relative bioavailability
    替沃噻吨的药动学特征与其相对生物利用度
短句来源
    Pharmacokinetics and relative bioavailability of nimodipine in healthy adults
    尼莫地平在健康人体的药物动力学与相对生物利用度
短句来源
    RELATIVE BIOAVAILABILITY OF ACETAMINOPHEN MASTICATION TABLET
    扑热息痛咀嚼片的相对生物利用度研究
短句来源
    Relative Bioavailability and Bioequivalence Assessment of Domestic Amiloride Tablet
    国产氨氯吡咪片的相对生物利用度及其生物等效性评价
短句来源
    Relative bioavailability of domestic acyclovir tablet
    国产阿昔洛韦片的相对生物利用度
短句来源
更多       
  pharmacological bioavailability
    The relative pharmacological bioavailability of INS NP reached 59.2%.
    INSNP肺部给药的相对药理生物利用度达到59.2% 。
短句来源
    After subcutaneous administration of INS PCLA NP 12u·kg -1 , the hypoglycemic effect was significant. The pharmacological bioavailability of INS PCLA NP was 74.76%.
    药效学研究表明 ,12u·kg-1的INS PCLA NP经皮下给药后即有明显的降血糖作用 ,药理生物利用度为 74.76 %。
短句来源
    Compared to subcutaneous administration of insulin solution, the relative pharmacological bioavailability and the relative bioavailability of insulin-flexible nanoliposomes group were 15.59% and 19.78%, respectively. The insulin-flexible nanoliposomes group was higher than both insulin conventional liposomes group (P<0.05) and blank flexible nanoliposomes and insulin mixture group (P<0.05).
    以sc胰岛素溶液 (1U·kg- 1 )为对照 ,bu胰岛素柔性纳米脂质体组 (10U·kg- 1 )的药理相对生物利用度为 15 5 9% ,相对生物利用度为 19 78% ,高于bu胰岛素溶液对照组 (P <0 0 5 )、胰岛素普通脂质体组 (P <0 0 5 )及空白柔性纳米脂质体与胰岛素混合物组 (P <0 0 5 )。
短句来源
    RESULTS The mean diameter of INS-PLA-NP was 84.34±14.76 nm. After the administration of INS-PLA-NP,glucose levels dropped to 43.82%±10.41% in 0.5 h. The pharmacological bioavailability was 133.51%.
    结果 INS -PLA -NP平均粒径为 84 34± 14 76nm ,给药后 0 5h血糖即降至最低(43 82 %± 10 4 1% ) ,并具有良好的缓释作用 ,药理相对生物利用度达到 133 5 1%。
短句来源
    When given buccally, bacitracin, aprotinin and sodium deoxycholate could increase the relative pharmacological bioavailability of insulin.
    胰岛素溶液中加入杆菌肽、屈来赛多及去氧胆酸钠后 ,给正常大鼠口腔喷雾给药 ,与皮下注射胰岛素比较 ,药理相对生物利用度分别有不同程度的提高。
短句来源
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      bioavailability
    This indicated that the accumulation pathways of Cu and the processes affecting the bioavailability of Cu to the mussel are different from those for Cd, Pb, and Zn.
          
    Such flooding reaching an amplitude of about ten meters causes dramatic changes in the bioavailability of nutrients and oxygen levels and poses extreme constraints for plant survival and reproductivity.
          
    We evaluated the chemical activity and bioavailability of heavy metals in the tidal flat based on the molar ratio of simultaneously extracted metals (SEM) and AVS.
          
    This reduces the molecular weight and increases the bioavailability, indicating better ADME properties.
          
    In this paper, progresses in researches on physiology of Zn deficiency in animals, phytate effect on bioavailability of Zn, and role of phytase in healing Zn deficiency of animals were reviewed.
          
    更多          
      biological availability
    A new approach was proposed to fractionating soil lead species differing in mobility and biological availability.
          
    The index of biological availability of 137C in the soil is proposed, and its linear dependence on the coefficients of 137Cs transfer to wood is demonstrated.
          
    A close negative correlation between the biological availability of 90Sr and 137Cs for agricultural crops and the content of exchangeable calcium in soils has been revealed in a field experiment performed for soddy-podzolic loamy sandy soil.
          
    The question arises whether the absorption of minocycline is less reliable than previously thought or whether the film-coated tablets of minocycline used in this study may have lower biological availability than the capsules used in previous studies.
          
    Pharmacokinetics and biological availability of erythromycin
          
    更多          
      relative bioavailability
    Conclusions: The results confirm that the relative bioavailability of β-carotene depends largely on the source of b-carotene and demonstrate the superior bioavailability of β-carotene powder in comparison to that in carrot juice.
          
    The relative bioavailability in humans of elemental iron powders for use in food fortification
          
    A comparison between microcrystalline and conventional phenytoin preparations: Relative bioavailability and steady-state plasma
          
    The relative bioavailability was about 2-3 times higher after bacampicillin as compared to ampicillin.
          
    Relative bioavailability was 105% (tablet/capsule).
          
    更多          
      bioavailability bioequivalence
    Objective: To assess the pharmacokinetics and relative bioavailability/bioequivalence of three commercial tablet formulations of mefloquine, i.e.
          
    Characterization of the Human Upper Gastrointestinal Contents Under Conditions Simulating Bioavailability/Bioequivalence Studies
          
      其他


    Nithiocyamine is poorly soluble in water, whose GI absorption is rate limited by

    硝硫氰胺难溶于水,其吸收受溶解速度所限制。微粉化减低粒子大小后,通常可增加吸收和总生物利用度。但由微粉化而得到粒子的巨大表面上所附有的自由能,使其成为热力学不稳定体系。选择无生理活性、易溶载体聚乙二醇6000,以熔融法制备成固体分散物。X-射线衍射实验证实为热力学稳定的间充固体溶液。发现硝硫氰胺-聚乙二醇6000(1:9)固体分散物的溶解速度,分别为微粉化和纯硝硫氰胺的10.6倍和15倍。小白鼠体内研究,微粉化硝硫氰胺24小时血浓曲线下的总面积,只有硝硫氰胺-聚乙二醇6000固体分散物的59%。

    The bioavailability of eye drops (prepared with saline and buffered solutions) of Bao Gong Teng A(isolated from Erycibe obtusfolia Benth) have been studied by using the pharmacological response(miotic action). The change in pupillary diameter of the rabbit eye is chosen as a graded quantitative pharmacological response to indicate the change of intensity. The observed pharmacological data are converted, via the use of a dose-effect curve, to values corresponding to the relative biophasic drug levels. The relative...

    The bioavailability of eye drops (prepared with saline and buffered solutions) of Bao Gong Teng A(isolated from Erycibe obtusfolia Benth) have been studied by using the pharmacological response(miotic action). The change in pupillary diameter of the rabbit eye is chosen as a graded quantitative pharmacological response to indicate the change of intensity. The observed pharmacological data are converted, via the use of a dose-effect curve, to values corresponding to the relative biophasic drug levels. The relative bioavailability of saline solution of Bao Gong Teng A is computed from the ratio of the total areas under the curves (AUG) plotted with the relative biophasic drug levels of both solutions versus time. The results demonstrate that in comparison with saline solution the relative bioavailability of buffered solution of Bao Gong Teng A is 60% (P<0.05).

    本文报告用药理指标测定了两种包公藤甲素缩瞳剂的相对生物利用度。兔瞳孔直径的变化选作为分级定量的药理效应强度指标。观察的药理效应强度通过剂量-效应曲线,转换成相应的生物相药物浓度。然后,通过药一时曲线下面积计算包公藤甲素两种缩瞳剂的相对生物利用度。结果表明,用磷酸缓冲液(pH7)配制的缩瞳剂与用氯化钠调整渗透压配制的缩瞳剂(pH6)相比,其相对生物利用度为60%(P<0.05)。

    The dissolution rates of 28 tetracycline tablet samples obtained from various factories were determined. The absorption of six of the 28 samples were determined using tetracycline solution as reference standard in 18 volunteers by urine test for 72 hours. The absorption of two of the six samples were also determined in ten volunteers by plasma test for 12 hours. The observed absorption of the six samples showed distinct statistical difference. The availabilities of the six samples were 87.40%, 81.40%, 79.08%,...

    The dissolution rates of 28 tetracycline tablet samples obtained from various factories were determined. The absorption of six of the 28 samples were determined using tetracycline solution as reference standard in 18 volunteers by urine test for 72 hours. The absorption of two of the six samples were also determined in ten volunteers by plasma test for 12 hours. The observed absorption of the six samples showed distinct statistical difference. The availabilities of the six samples were 87.40%, 81.40%, 79.08%, 75.15%, 57.05% and 39.15% respectively. The correlation between bioavailability and dissolution rate was not significant. A dissolution rate limit was suggested.

    对来自不同厂家生产的28个批号的四环素片,在测定溶出速度的基础上,选择了6个样品在18个人体上进行了生物利用度试验。试验采取交叉服药,每周一次,每次0.5g四环素片,连续6周,以四环素溶液为参考标准,测定了18个人72小时尿药浓度。其中2个样品测定了10个人12小时的血药浓度。含量用荧光法测定。结果说明6个样品的吸收置存在显著性差异。生物利用度分别为87.40%,81.40%,79.08%,75.15%,57.05%,39.15%。生物利用度与溶出速度之间的相关关系不显著。此外,根据体内实验结果提出了四环素片剂溶出速度的限度。

     
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