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      谷氨酸诱导
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  glutamate-induced
     The effect of c-fos antisense oligonucleotide on apoptosis of glutamate-induced hippocampal neurons and PC12 cell line
     c-fos反义寡核苷酸对谷氨酸诱导PC12及海马神经元凋亡的影响
短句来源
     Effects of ATP-sensitive Potassium Channels Opener Iptakalim on Glutamate-induced Cytotoxicity in PC12 Cells
     ATP敏感性钾通道开放剂埃他卡林对谷氨酸诱导PC12细胞损伤的保护作用
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     Effect of Propofol on Glutamate-induced Apoptosis and Related Gene Expression of Spinal Cord Dorsal Horn Astrocytes in Wistar Rats
     异丙酚对谷氨酸诱导大鼠脊髓背角星形胶质细胞凋亡及相关基因表达的影响
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     Objective To observe the effect of ketamine on Glutamate-induced apoptosis and the intracellular dissociated Ca~(2+) concentration([Ca~(2+)]i) in rat cultured spinal cord dorsal horn astrocytes.
     目的:观察氯胺酮对谷氨酸诱导大鼠脊髓背角星形胶质细胞凋亡和胞内游离钙浓度([Ca2+]i)变化的影响。
短句来源
     Objective To observe the effect of different concentrations of propofol on glutamate- induced astrocyte injury in the dorsal horn of the spinal cord in rats.
     目的:观察不同浓度异丙酚对谷氨酸诱导大鼠脊髓背角星形胶质细胞损伤的影响。
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  “谷氨酸诱导”译为未确定词的双语例句
     Par-4-AS-ODN inhibited the increase of calpain 10 mRNA in PC12 cells induced by glutamate(46.3±3.7 vs 3 4.8±2.1, P<0.01).
     谷氨酸诱导PC12细胞内钙依赖性蛋白酶Calpain10mRNA水平上调( 46 .3±3 .7 ),par- 4反义寡核苷酸抑制其上调(34 8±2 1,P<0 01 )。
短句来源
     Par-4-AS-ODN significantly inhibit ed the apoptosis of PC12 cells induced by glutamate(53% vs 31%, P<0.01).
     谷氨酸诱导凋亡组凋亡百分率为53%, par -4反义寡核苷酸拮抗谷氨酸诱导的PC12细胞凋亡(31%,P<0. 01);
短句来源
     (2) Par-4-AS-ODN could resist the decrease of phosphorylated ERK_ 1/2 (Thr202/Tyr204) induced by glutamate in PC12 cells.
     (2)谷氨酸诱导PC12细胞中磷酸化(Thr202/Tyr204)的ERK1/2蛋白水平下调,par-4反义寡核苷酸拮抗其上调(组间比较,P<0.01)。
短句来源
     Methods Using RT-PCR and Western Blot methods,the changes of AMPA receptor GluR2 subunit mRNA and protein expressions were observed in cultured hippocampal neurons of rats induced by glutamate.
     方法用RT-PCR和Western Blot方法观察谷氨酸诱导培养大鼠海马神经元AMPA受体Glu R2亚单位mRNA和蛋白的表达变化。
短句来源
     Par-4-AS-ODN significantly suppress the up-regulation of intracellular calc ium concentration in PC12 cells induced by glutamate(Rate of fluorescent densit y: 167.9±32.4 vs 228.8±36.8, P<0.01).
     谷氨酸诱导PC12细胞内游离钙离子浓度上调,par- 4反义寡核苷酸拮抗其上调(荧光强度比值分别为167 .9±32 .4、228. 8±36. 8,P<0 .01);
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  相似匹配句对
     Protection of caffeine against neuronal apoptosis induced by glutamate
     咖啡因对谷氨酸诱导神经元凋亡的保护作用
短句来源
     Effect of oleanolie acid on cultured neuronal cells treated with glutamic acid
     齐墩果酸对谷氨酸诱导神经细胞损伤的影响
短句来源
     The higher the quartity of amino acid Glu.
     谷氨酸(Glu.)
短句来源
     in troducing stimulus;
     诱导刺激;
短句来源
     ,Glu.
     、谷氨酸(Glu.)
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  glutamate-induced
Current data on glutamate-induced functional and morphological changes in mitochondria correlating with or being a result of their membrane potential changes are reviewed.
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It is assumed that glutamate-induced loss of mitochondrial potential is mediated by Ca2+ overload resulting in the induction of nonspecific permeability of the inner mitochondrial membrane.
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It is shown that at low concentrations (≤10 nM) thrombin and FXa protect neurons from glutamate-induced excitotoxicity.
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A proteomic analysis of the effect of mapk pathway activation on l-glutamate-induced neuronal cell death
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Bis(7)-Tacrine, a promising anti-Alzheimer's agent, attenuates glutamate-induced cell injury in primary cultured cerebrocortical
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         Objective:To investigate the effects of cholecystokinin-octapeptide(CCK-8)on glutamate-induced neurotoxicity in rat cerebral cortical neurons.Methods:The cytomorphological changes of cul-tured neuron treated by various factors were observed with scanning electron microscopy and LDH Iev-els in medium were measured with LDG-L kit.Results:CCK-8 may significantly attenuate destruction of neuronal structure induced by glutamate,and inhibit the LDH Ievels. The action of CCK-8 was blocked by CCK_B receptor antagon...
            目的:探讨八肽胆囊收缩素(CCK-8)对谷氨酸神经兴奋毒性的作用。方法:采用神经元原代分离培养技术,应用电镜观察经不同药物处理后的大鼠大脑皮层神经元的形态学变化,同时测定细胞上清液中LDH活性值,并进行t检验等统计学分析。结果:CCK-8能明显改善由谷氨酸诱导的神经元结构的破坏和减少神经元损伤后LDH的释放,该作用可被CCK_B受体拮抗剂阻断。结论:CCK-8可通过B受体介导产生对谷氨酸神经毒性的拮抗作用。
文摘来源
         To study action of IL-1 involved in neurotoxicity. Methods: The effects of IL-1ra(IL-1 receptor antagonist, IL-1ra) on glutamate-induced neurotoxicity were examined using cultured ratcortical neurons with Trypan blue exclusion and scan electromicroscope. Meanwhile, effects of IL-1β onexpression of NMDAR1 mRNA were observed in cultures. Results: IL-1ra (1mg/L) may significantlyinhibit neuronal damage induced by glutamate at concentration of 0. 5 mmol/L F IL-1β dose-deppndentlypromoted expression of NMDAR1 mR...
            目的:探讨白细胞介素-1(Interleukin-1,IL-1)在神经兴奋毒性中的作用。方法:以培养的胚胎大鼠大脑皮层神经元为研究对象,用台盼蓝染色和扫描电镜观察了IL-1ra(IL-1受体拮抗剂)对谷氨酸诱导的培养神经细胞毒性的影响;用Northern印迹杂交观察了IL-1β对培养神经细胞NMDARI(NMDA受体Ⅰ型亚单位)mRNA表达的影响。结果;IL-1ra(mg/L)可明显抑制谷氨酸(0.5mmol/L)引起的神经细胞毒性作用;IL-1β在1~50u/ml浓度范围内可剂量依赖地促进NMDARImRNA表达,IL-1ra可阻断此效应。结论;内源性IL-1参与了谷氨酸诱导神经细胞毒性的病理过程,其作用机制之一可能是促进了NMDARImRNA的表达。
文摘来源
         IM: To determine whether the extract of leaves of Ginkgo biloba L (EGb) and several active constituents of EGb have protective effects against glutamate (Glu) induced neuronal damage. METHODS: Microscopy and image analysis of nucleus areas in the arcuate nuclei (AN) of mice were made. The neuronal viability in primary cultures from mouse cerebral cortex was assessed using MTT [3 (4,5 dimethylthiazol 2 yl) 2,5 diphenyl tetrazolium bromide] staining and the intracellular free calcium concentration ([...
            目的:观察EGb及其所含成分槲皮素和内酯B对谷氨酸诱导的神经元损伤的拮抗作用.方法:对小鼠下丘脑弓状核作形态学观察和图象分析,采用MTT法检测皮层原代培养神经元的活性,用Fura2测定单个神经元内游离钙离子的浓度([Ca2+]i).结果:EGb及其内酯B能够保护神经元对抗谷氨酸的损伤,阻止谷氨酸诱发的[Ca2+]i的升高.EGb能够逆转谷氨酸诱导的下丘脑弓状核神经元核面积的减少.结论:EGb及其内酯B可以通过降低[Ca2+]i水平对抗谷氨酸神经毒性,内酯B很可能是EGb中对抗谷氨酸神经毒性的主要成分之一.
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