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      n连接型
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  n linked
     STUDY ON THE MECHANISM OF CHANGES IN N LINKED SUGAR CHAIN STRUCTURE OF ERYTHROID PROGENITOR CELLS SURFACE IN VITAMIN A DEFICIENCY RATS
     维生素A缺乏大鼠红系祖细胞表面N连接型糖链结构改变的机理研究
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     Objective: To clarify the mechanism of abnormality of N linked sugar chain structure of erythroid progenitor cells (EPC) caused by vitamin A deficiency (VAD).
     目的:阐明维生素A缺乏(VAD)引起大鼠红系祖细胞(EPC)表面N连接型糖链结构改变从而导致EPC增殖分化障碍的机理。
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     Objective To study the N linked oligosaccharides of tumor related glycoprotein in bile and its diagnostic value for bile duct carcinoma.
     目的 研究胆管癌胆汁中的肿瘤相关糖蛋白N 连接型糖链结构及其诊断价值。
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  “n连接型”译为未确定词的双语例句
     Objective To investigate the differences between hepatoma tissues and tissues surrounding hepatoma in enzyme activity and asparagine linked sugar chain structures of gamma glutamyl transpeptidase(γ GT).
     目的 比较肝癌组织和肝癌旁组织中γ 谷氨酰转肽酶 (γ GT)活力及其N 连接型糖链结构的变化。
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  相似匹配句对
     (3)D shape.
     D
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     K-type Local Connection Neural Network
     K局部连接神经网络
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     (2)C shape;
     C ;
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     Minimize connective finite automata and Its complexity
     连接自动机的极小化及其复杂性
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     brassii type; N.
     brassii ,N .
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  n linked
In this paper it is shown that the genetic algebra of an infinitely large random mating population of polyploid individuals which differ at n linked loci, between which recombination may occur, is a genetic algebra.
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Thus, we identified the L-Arap4N linked to the first Kdo of the LPS of P.
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After passage through the column, the mitogenic activity was found in the flow-through, indicating that it did not carry N-linked sugar residues.
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Additional experiments are needed to define the N-linked oligosaccharide structures required for mouse postembryonic day 9 ontogeny.
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About 44% of the radioactivity coeluted with the N-linked complex-type glycopeptide marker, and only 16% was eluted as a species of lower MW.
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         We studied the effect of RA on the structure of N-linked oligosaccharides of surface glycoproteins isolated from cultured keratinocytes. The results show that RA can stimulate the synthesis of N-linked oligosaccharides with 43.5 % of 3H-man-nose incorporation into N-linked oligosaccharides ;RA alters the type ratio of N-linked oligosaccharides with the increase of complex type percentage, for which only the tri- and tetra-antennary will response but not the biantennary ;RA makes the complex type contain mor...
            维生素A类化合物对糖蛋白N-连接型糖链(简称N-糖链)结构的影响,近年来在研究其作用机制中颇受重视。本文研究视黄酸(RA)对大鼠皮肤上皮基底培养细胞表面膜糖蛋白糖链结构作用,发现RA促进N-糖链合成,使~3H-甘露糖掺入糖链量增加43.5%,RA可改变N-糖链的类型,促进复杂型N-糖链合成,表现为增加三、四天线复杂型N-糖链合成而不是二天线;RA还使含分叉性GIeNAc和核心Fuc的百分比上升。本文还用细胞电泳方法研究膜表面唾液酸相对量,发现RA可引起唾液酸含量下降。结果提示RA对N-糖链结构的影响,是其多种生物学作用的可能途径之一。
文摘来源
         Tunicamycin is an inhibitor of the synthesis of N-linked oligosaccharide on glycoprotein. It was found that the growth of human hepatoca.rclnoma cell line SMMC-7721 was inhibited by tunicamycin; the inhibitory rate was proportional to the dose and the duration of tunicamycin treatment. After 18 hours of tunicamycin treat ment,a significant inhibition of the incorporation of ~3H-mannose and ~3H-glucosamine, but slight inhibition of the incorporation of ~3H-leucine into cell was observed. The inhibitory rate ...
            衣霉素(Tunicamycin)是一种糖蛋白N-连接型糖链合成的抑制剂。它可抑制人肝癌细胞抹SMMC-7721的生长,其抑制率和剂量及处理时间有相关性。衣霉素处理细胞18h尚可显著抑制~3H-甘露糖和~3H-氨基葡萄糖参入细胞,但仅轻度抑制~3H-亮氨酸的参入。这些标记化合物的参入抑制都有量效关系。0.1gg/mL衣霉素处理18h后,细胞表面胰岛素受体和胰岛素的结合容量下降,而对照细胞和处理细胞的胰岛素竞争结合曲线基本平行。这主要由于衣霉素抑制新合成的胰岛素受体的糖基化所致。我们对糖基化障碍引起细胞膜胰岛素受体结合容量降低的机理作了讨论。
文摘来源
         In order to study the effect of marginal vitamin A deficiency(MVAD) on N linked glycopeptides of erythroid cell surface,the glycopeptides labeled 3 H mannose from cultured erythroid cell in rats were studied by serial lectin affinity chromatography combined with exoglycosidase treatment and gel filtration.The results showed that MVAD decreased incorporation of 3 H Mannose into N linked glycopeptides on erythroid cell surface,increased the perc...
            为研究边缘型维生素A缺乏(MVAD)对大鼠红系细胞膜N连接型糖链(N糖链)的影响,采用系列凝集素柱层析法,并配合外切糖苷酶,研究MVAD对红系细胞分化过程中细胞膜N糖链的影响,结果显示,MVAD引起大鼠红系细胞膜N糖链合成减少,复杂型糖链下降,高甘露糖型及杂合型糖链上升;天线数无变化;复杂型糖链中不含分叉型N乙酰氨基葡萄糖(B-Gn)及核心岩藻糖(C-Fuc)组分下降,含B-Gn或C-Fuc或同时含B-Gn和C-Fuc组分增加,提示MVAD减少N糖链合成,阻碍糖链向成熟方向转化,使N糖链趋于较不成熟和分化较差,是细胞分化障碍的标志,它可能与细胞受体功能有关。
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