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  non-squamous
     Patients with extensive mediastinal lymph node metastasis, more node metastasis and non-squamous carcinoma showed significantly higher incidence of brain metastasis than those with limited mediastinal lymph node metastasis, fewer positive mediastinal lymph nodes and squamous carcinoma (P=0.000, P=0.000, P=0.013).
     多个区域纵隔淋巴结转移、多个纵隔淋巴结转移以及非鳞癌患者的脑转移发生率显著高于单区域纵隔淋巴结转移、纵隔淋巴结转移数目较少以及鳞癌患者(P=0.000,P=0.000,P=0.013)。
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     The number of the risk factors(blood g roup B and non-squamous )were neg atively related to prog nosis acc ording to multivariate analysis in s tag e Ⅲa NSCLC(the 5-year survival rates:43.5%vs 23.7%vs 4.0%,P<0.001).
     随着预后不良因素(非鳞癌和B型血)的增加,Ⅲa期患者5年生存率相应呈下降的趋势(43.5%vs23.7%vs4.0%,P<0.001)。
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     56 in 90 (62.2%) NSCLC showed absence of Fhit and 44 in 90 (48.9%) showed mutation expression of p53. Fhit and p53 abnormalities showed close correlation in non-squamous cell cancer(P<0.001),but showed no correlation in squamous cell cancer(P=0.079);
     [结果]62.2%(56/90)的NSCLC组织显示Fhit表达缺失,同时48.9%(44/90)有突变型p53表达; 两者的异常表达在非鳞组中明显相关(P<0.001),而在鳞癌组中无相关性(P=0.079);
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     The difference between two groups was statistically significant(χ 2=50.29,P<0.01). The coexpression of p63 and CK5/6 protein were found in 39.2%(40/102) of squamous cell carcinomas and 3.1%(3/98) of non-squamous carcinomas respectively. The difference between two groups was statistically significant(χ 2=38.71,P<0.01).
     p6 3和CK5 / 6蛋白在鳞癌和非鳞癌组织联合表达率分别为39 .2 % (40 / 10 2 )和3 .1%(3/ 98) ,前者高于后者(χ2 =38 71,P <0 . 0 1)。
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     Results (1) The average age of cervical carcinoma onset gradually decreased over the past 50 years, from 56.27±8.45 in years 1955~1964 to 43.81±8.9 in years 1995~2004. At the same time, the radio of clinically early (stages Ⅰ-Ⅱ) and non-squamous cancer also steadily increased.
     结果(1)近50年来宫颈癌的发病年龄逐渐降低,由1955~1964年的56.27±8.45岁降至1995~2004的43.81±8.90岁。 同时,临床早期(Ⅰ~Ⅱ期)的比例和非鳞癌的比例则逐步升高。
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     The frequency of loss of FHIT was significantly higher in squamous cell carcinomas (SqCCs)than that in non-SqCCs(72.7% vs 39.1%;χ2=6.32,P=0.012).
     肺鳞癌(SqCCs)中FHIT蛋白缺失率明显高于非鳞癌(non SqCCs)(72.7%vs39.1% ;χ2 =6.32,P=0.012) ;
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     26% and 62% for squamous and non squamous cell carcinoma ( P <0 001);
     鳞癌为26%,非鳞癌为62%9(P<0.001);
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     The percentage of adenocarcinoma and others in studygroup was 32.1%(17/36),but 8.6%(54/625)in control group(P<0.001).
     非鳞癌患者所占比例研究组为32.1%(17/36),对照组仅8.6%(54/625)(p<0.001)。
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     The 1 and 2 year survival rates were as follows:squamous 80.3%,43.6%,nonsquamous 62.4%,32.1%( P =0.005);
     在各分组中,一、二年生存率为:鳞癌患者80.3%,43.6%,非鳞癌患者62.4%,32.1%(P=0.005);
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     ,except that Fhit abnormal expression was found more in smokers (P= 0.032),and in squamous cell cancer(SqCC,P<0.001) whole P16 was seen more often in non-SqCC(P=0.025),and that P53 positive expression was significantly higher in N2 metastasis(P=0.039).
     除了Fhit异常表达显著多见于鳞癌 (SqCC ,P <0 .0 0 1)和吸烟者 (P =0 .0 32 )、P16多见于非鳞癌 (non SqCC)以及P5 3异常多见于N2淋巴结转移 (P =0 .0 39)外 ,三者的异常表达与其他临床病理参数 (包括年龄、性别、肿瘤大小和分期等 )均无相关性。
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  相似匹配句对
     (3)The scales were in a form of irregular non-circularity.
     (3)片层均为形状不规则的环形片。
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     26% and 62% for squamous and non squamous cell carcinoma ( P <0 001);
     癌为26%,癌为62%9(P<0.001);
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     Bronze in Lijiashan
     主流的青铜
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     There will be no Bodhi-tree eventually
     菩提
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     and squamous cell carcinoma was negative.
     癌阴性。
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  non-squamous
The percentage of lymphocytes in the differential was greatest in those with non-squamous cancer histology.
      
We reviewed the MR images and pathologic findings of five cases of primary vaginal neoplasms of non-squamous origin.
      
Non-squamous epithelia showed lack of filaggrin expression.
      
FDG PET and PET/CT for the detection of the primary tumour in patients with cervical non-squamous cell carcinoma metastasis of a
      
In patients with a neck metastasis from an unknown primary with non-squamous cell cancer (non-SCC) histology, the primary is often located outside the head and neck area.
      
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To investigate the negative expression of Fragile Histidine Triad gene protein (Fhit) and its correlation with mutated p53 gene protein(p53) expression in non-small cell lung carcinomas(NSCLC). Fhit and p53 expressions in NSCLC tissues were detected by immunohistochemistry method. 56 in 90 (62.2%) NSCLC showed absence of Fhit and 44 in 90 (48.9%) showed mutation expression of p53. Fhit and p53 abnormalities showed close correlation in non-squamous cell cancer(P<0.001),but showed no correlation in squamous...

To investigate the negative expression of Fragile Histidine Triad gene protein (Fhit) and its correlation with mutated p53 gene protein(p53) expression in non-small cell lung carcinomas(NSCLC). Fhit and p53 expressions in NSCLC tissues were detected by immunohistochemistry method. 56 in 90 (62.2%) NSCLC showed absence of Fhit and 44 in 90 (48.9%) showed mutation expression of p53. Fhit and p53 abnormalities showed close correlation in non-squamous cell cancer(P<0.001),but showed no correlation in squamous cell cancer(P=0.079);while,Fhit and p53 abnormalities showed close correlation in non-smokers(P=0.006),but showed no correlation in smokers(P=0.113). [Conclusions] Negative expression of Fhit and mutation expression of p53 are frequent events in NSCLC. Moreover, there is a significant relationship between Fhit negative expression and mutated p53 expression in non-SqCC and non-smokers.

[目的]了解非小细胞肺癌组织(NSCLC)中脆性组氨酸三联体(FHIT)基因蛋白(Fhit)表达缺失及其与突变型p53基因蛋白(p53)表达的相关性。[方法]应用免疫组织化学方法了解NSCLC组织中Fhit及p53的表达。[结果]62.2%(56/90)的NSCLC组织显示Fhit表达缺失,同时48.9%(44/90)有突变型p53表达;两者的异常表达在非鳞组中明显相关(P<0.001),而在鳞癌组中无相关性(P=0.079);另外,两者的异常表达在非吸烟组中明显相关(P=0.006),而在吸烟组中无相关性(P=0.113)。[结论]Fhit表达缺失和突变型p53表达是NSCLC中常见事件;而且两者在non-SqCC和非吸烟的肺癌者中有明显的相关性。

Comparison of some palynological and palaeobotanical data mainly related to Late Palaeozoic and Mesozoic strata of China reveals that the discrepancy of their geological records is a phenomenon rather common than essentially harmonious as expected. This kind of discrepancy largely stems in the difference of chemical composition between spore exine and cell wall of other plant organs as well as the high production of spores and pollen (e.g., for a single plant, grains of spores or pollen versus the number of...

Comparison of some palynological and palaeobotanical data mainly related to Late Palaeozoic and Mesozoic strata of China reveals that the discrepancy of their geological records is a phenomenon rather common than essentially harmonious as expected. This kind of discrepancy largely stems in the difference of chemical composition between spore exine and cell wall of other plant organs as well as the high production of spores and pollen (e.g., for a single plant, grains of spores or pollen versus the number of leaves or pinna). Other factors, such as the transportation, allochthonous or autochthonous burial, sedimentary environment (pH, and Eh, etc. included), lithology, plant ecology and preservation modes, also have influence on this discrepancy. The discrepancy has led to different interpretations on some significant problems in palaeobotany and geochronology such as (1) phytoprovincialism of Northern Xinjiang and the Tarim Basin, (2) Latest Carboniferous-Permian and Mesozoic coal-forming plants in China, (3) Palaeophyte/Mesophyte boundary and the so called plant mass extinction at the end of Permian, (4) the earliest record of some plant groups (vascular-, heterosporous-, coniferous-, and angiospermous-plants), and (5) geological dating of some terrestrial or facies-transitional formations (the Qubu Fm. in S. Tibet, Kayitou Fm. in E. Yunnan and W. Guizhou, Taliqik Fm. in Tarim, and Yixian Fm. in W. Liaoning). Somewhat different from or in contrast to those interpretations based on plant megafossils, the relevant conclusions drawn from the palynological data are as follows: (1) Northern Xinjiang had belonged to the Subangara area since the early Late Carboniferous (early Bashkirian) to Permian, whereas the Tarim Basin became part of the Subangara area during the Early Permian. (2) Tree ferns (e.g. Psaronius) rather than arborescent lycopods were the major peat-formers of the Chinese latest Carboniferous and Permian coals, in importance order the rest contributors are other ferns and pteridosperms, articulates (sphenophylls, Calamites, etc.), lycopods including Lepi- dodendron etc., and cordaitaleans. Comparable to this situation to some extent, for the Chinese Mesozoic coal formation, tree ferns (Cyatheaceae and Dicksoniaceae) also played a main role together with ginkgos, cycads, araucariaceae, other conifers and pteridophytes. (3) If we follow some authors and take the advanced “Mesozoic pteridosperm” Peltaspermales (Protohaploxypinus s.l. + Vittatina producers) as component of Mesophyte, then the base of Mesophyte would remarkably come down to somewhere within Bashkirian or at Bashkirian-Moscovian boundary of the early Late Carboniferous. Because then gymnospermous, especially striate pollen dominance (GSPD) began in the Subangara area! That means the onset of Mesophyte in the Subangara area is much earlier than at the base of Zechstein as has been traditionally defined. (4) Several Permo-Triassic transitional palynofloras found from basal Lower Triassic units in China (the Kayitou Fm. in E. Yunnan, the lower Qinglong Fm. in Zhejiang and the upper part of Guodikeng Fm. and Jiucaiyuan Fm. in Xinjiang) seem not to support the assumption advocating a mass extinction of land plants also happened at the end of Permian. (5) As regards the origin of some plant groups, the dispersed spore or pollen record is generally earlier than that of plant megafossils, for example, the earliest coniferous Potonieisporites has been recorded from late Serpukhovian or around the Serpukhovian/Bashkirian boundary VS megafossil conifers around Westphalian A-B; and similarly megaspores already known from the early Emsian that is also earlier than the known heterosporous plant megafossils (possibly a Middle Devonian lycopod, Meyen, 1987). In order to reduce the potentially misleading interpretations about these problems based solely on either dispersed spores or fossil plants, it is important for researchers to combine the palaeobotanical and palynological data as far as possible, and to develop the study of in situ spores.

分散孢粉与植物大化石地质记录的不一致是常见现象,基本上是受孢粉的高产量及其外壁的较强抗腐蚀性,以及沉积环境的影响所致。主要根据我国古、中生代孢粉及植物化石资料,举例说明其地质记录的差异和其导致的不同解析和结论,及其古植物学意义。涉及的问题包括:1.新疆北部石炭二叠纪和塔里木盆地二叠纪的植物区系性质,2.我国古、中生代的主要成煤植物,3.古植代/中植代界线和植物在二叠纪末有无群体灭绝,4.某些植物类群的最早化石记录或起源,5.某些地层的地质时代问题。本文对此等问题提出的与古植物学家不甚一致的结论,如塔里木自早二叠世已属亚安加拉区,我国古、中生代主要成煤植物是真蕨类尤其是树蕨,而非鳞木类、科达类,或中生代裸子植物;如果将盾籽类作为中植代植物,则古植代/中植代界线在亚安加拉区要下降到Bashkirian之内或Bashkirian Moscovian之交,等等,是否正确,有待检验。

The treatment of non-small cell lung cancer (NSCLC) was not initial 40 years ago.The concept for multimodulaty combination treatment was still constructed.Periphyreal lung cancer operation treatment was lobectomy with lymph nodes sampling.The 5-year survival rate of early stage NSCLC operation treatment was only about 30 percent.Chemotherapy agents in treatment of NSCLC were mainly Nitrogen mustart and Nitromin.1-year survival of advanced NSCLC had only 10 percent.Radiotherapy used deeply x-ray or 60Co.At present,there...

The treatment of non-small cell lung cancer (NSCLC) was not initial 40 years ago.The concept for multimodulaty combination treatment was still constructed.Periphyreal lung cancer operation treatment was lobectomy with lymph nodes sampling.The 5-year survival rate of early stage NSCLC operation treatment was only about 30 percent.Chemotherapy agents in treatment of NSCLC were mainly Nitrogen mustart and Nitromin.1-year survival of advanced NSCLC had only 10 percent.Radiotherapy used deeply x-ray or 60Co.At present,there mainly were several advance:①the progression in operation:systematic lymph nodes resection,reconstruction of airway carina or vascular reconstitution,VATS,and surgery treatment of IV stage NSCLC in some given conditions,such as single lesions of both brain and lung completely resection,respectively,with survival improvement significantly.② the progression in radiotherapy:3DCRT and IMRT could enhance response rate with decreasing radiation damage in the lung.③ the progression in chemotherapy:overall response rate of the 3rd generation chemotherapeutic agents accounting for about 40 percent.The categories including:neoadjuvant chemotherapy,adjuvant chemotherapy,palliative chemotherapy and salvage chemotherapy.Of them,recently,both palliative and adjuvant chemotherapy which may improve survival time have reached consensus.④radiotherapy combination with chemotherapy :radiotherapy plus chemotherapy (concurrent or sequential chemoradiotherapy )being best option for local advanced NSCLC.⑤ the progression in biotherapy:EGFR-TKIs (Iressa or Tarceva ) in treatment of metastatic advanced NSCLC serving as 2nd or 3rd line agents were emphasized in Easthern and westhern countries,respectively.⑥ the progression in bio-chemotherapy:chemotherapeutic agents combination with Avastin treating non-squamous NSCLS ⑦ the progression in traditional Chinese medicine:clearly,traditional Chinese medicine improving quality-life and prolonging survival.

早期,非小细胞肺癌术后5年生存率只有30%左右,肺癌化疗主要药物是盐酸氮芥和氧化氮芥,晚期非小细胞肺癌的1年生存率只有10%左右,放射治疗是用深部X线或60钴。现在,有七个进展点:①手术治疗进展包括:系统淋巴结清扫术,气管隆凸或血管重建术及支气管成形术,电视胸镜技术(VATS)以及某些特定条件下Ⅳ期非小细胞肺癌的手术治疗(例如周围型肺癌脑转移,如果两者都是单个病灶可以手术完全切除);②放射治疗进展,三维适形放疗(3DCRT)和调强适形放疗(IMRT)提高了疗效且减少对周围肺组织的损伤;③化学治疗的进步:第3代化疗新药与铂类药物结合可把总有效率提高至40%左右,化疗类别进一步分为:新辅助化疗,术后辅助化疗,姑息性化疗和补救性化疗,其中,辅助性化疗和姑息性化疗近年来已得到确认;④放射治疗与化疗结合是局部晚期非小细胞肺癌的治疗模式;⑤生物治疗的进步,EGFR-TKIs(Iressa或Tarceva)已分别在东方和西方作为非小细胞肺癌二线或三线治疗药物;⑥Avastin与化疗药物相结合的生物化疗在非鳞性非小细胞肺癌的治疗中开创了新模式;⑦中医药治疗非小细胞肺癌具有改善生活质量和延长生存期的作用。

 
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