Immunohistochemically, all cases showed strongly positive for p16 , mildly to strongly positive for CK7, CK14 and CK19. Only 2 cases showed focally positive for CK20. Guided by D2-40 marker, 6 cases showed lymphatic invasion.
Conclusions E-cd and P16 play an important role in the pathogenesis and development of the gliomas and they are helpful to predicting the prognosis of the patients with gliomas.
To provide the highest penetration of the laser emission into a medium, the irradiation of samples were carried out with tuning far from the maximum of the Si-O bond absorption band (1055 cm-1) using the 10P16 line (Ωlas= 947.78 cm-1).
In addition to the known nuclear reaction 14N(n, γ)15N, which allows the nitrogen component of explosives to be detected, it is proposed to use the reaction 16O(n, p)16N (β-, γ) → 16O.
Multiplex methylation-sensitive PCR was employed in studying the methylation of the RB1 and CDKN2A/p16 promoter regions in 52 retinoblastomas.
Methylation of p16 was for the first time observed in retinoblastoma (9 tumors, 17%).
Aberrant methylation of the p16 promoter was the second mutation event in two tumors and was not accompanied by RB1 defects in one tumor.
Bao Gong Teng A(BGTA),a new miotic,is a benzoate crystal of constituent Aisolated from the aqueous extract of the Chinese medicinal herb Bao Gong Teng(Erycibeobtusifolia Benth.).In the years 1979-1980,0.025% BGTA was compared with 2%pilocarpine as eye drops in the treatment of 178 eyes with primary glaucoma,usingrandomized double-blind method.After one month's treatment,the average intraocularpressure was reduced by 14 mmHg and C value increased by 0.09 in BGTA groupwhile they were 13 mmHg and 0.14 in pilocarpine...
Bao Gong Teng A(BGTA),a new miotic,is a benzoate crystal of constituent Aisolated from the aqueous extract of the Chinese medicinal herb Bao Gong Teng(Erycibeobtusifolia Benth.).In the years 1979-1980,0.025% BGTA was compared with 2%pilocarpine as eye drops in the treatment of 178 eyes with primary glaucoma,usingrandomized double-blind method.After one month's treatment,the average intraocularpressure was reduced by 14 mmHg and C value increased by 0.09 in BGTA groupwhile they were 13 mmHg and 0.14 in pilocarpine group,however,the differences were not statistically significant.Both drugs were generally effective for partial adhe-sion closed-angle glaucoma with comparatively better trabecular function(C>0.1),but ineffective for near complete adhesion closed-angle glaucoma with C<0.1.Therewere little side-effect and no allergy to BGTA observed.The data indicate that for thetreatment of primary glaucoma BGTA eye drops is just as effective as pilocarpine.
本文通过各种类型的原发性青光眼共122例178只眼,对比使用包甲素和毛果芸香碱两药的降压效果.包甲素用药前后眼压差值的平均数为14毫米汞柱,毛果芸香碱为13毫米汞柱,两药均有显著降压效果(P 均<0.01),但降压值相仿(P>0.05).另外,包甲素组用药前后房水流畅系数(C 值)增加幅度为0.09,毛果芸香碱组为0.13,两药用药前后 C 值都有显著改善(P 均<0.01);但两药相互间无明显差别(P>0.05).对于急性充血性青光眼,两药也都有较好的治疗效果.因此,包甲素可以作为治疗原发性青光眼的一种良好缩瞳药物.
The A(dz/dt)max and P-A interval of impedance cardiogram were studied inpatients with positive Ptf in V_1 lead of ECG(POS-PtfV_1≤-0.03 mms,n=32)andcoronary heart disease(CHD,n=32),with 55 normal subjects served as controls.Thenormal value of maximum negative amplitude of A wave was 0.41±0.02Ω/sec(mean±SD),and that of P-A interval was 109.85±34.86 msec.The A(dz/dt)max and P-Ainterval of the POS-PtfV_1 group were 0.69±0.39Ω/sec and 144.69±41.58 msec,andthose of CHD group were 0.82±0.33Ω/sec and 149.06±21.76 msec...
The A(dz/dt)max and P-A interval of impedance cardiogram were studied inpatients with positive Ptf in V_1 lead of ECG(POS-PtfV_1≤-0.03 mms,n=32)andcoronary heart disease(CHD,n=32),with 55 normal subjects served as controls.Thenormal value of maximum negative amplitude of A wave was 0.41±0.02Ω/sec(mean±SD),and that of P-A interval was 109.85±34.86 msec.The A(dz/dt)max and P-Ainterval of the POS-PtfV_1 group were 0.69±0.39Ω/sec and 144.69±41.58 msec,andthose of CHD group were 0.82±0.33Ω/sec and 149.06±21.76 msec respectively.Both parameters in the CHD and POS-PtfV_1 groups were significantly higher than thosein the control group(P<0.001).It appears that the A(dz/dt)max and P-A intervalof impedance cardiogram may be of value in the evaluation of cardiac performance.
The effect of pentobarbital on cerebral protection and brain monoamine levels during cerebral ischemia were studied in 60 Mongolian gerbils. The animals were randomly divided into three groups. Pentobarbital(n = 20)and control(n = 20) groups which underwent left common carotid artery (CCA) ligation received 60 mg/kg of Pentobarbitalum natricum and equal volume of normal saline respectively at 30 min prior to operation. Sham-operated group (n=20)was treated as same as the control group with exception of not ligating...
The effect of pentobarbital on cerebral protection and brain monoamine levels during cerebral ischemia were studied in 60 Mongolian gerbils. The animals were randomly divided into three groups. Pentobarbital(n = 20)and control(n = 20) groups which underwent left common carotid artery (CCA) ligation received 60 mg/kg of Pentobarbitalum natricum and equal volume of normal saline respectively at 30 min prior to operation. Sham-operated group (n=20)was treated as same as the control group with exception of not ligating CCA. The heurological deficits were evaluated and brain monoariiines measured at the third nour after operation.It was found that the stroke index was reduced, neurological deficits improved and brain norepinephrine(NE), dopamine(DA)and 5-hydroxytrytamine(5-HT) elevated to normal levels in pentobarbital-treated animals. There were significant negative correlations between stroke indexes and the levels of NE, DA and 5 -HT in ischemic brain (r = -0.485, -0.497 and 0.579 respectively, P<0.01 in all).The results suggest that the protective effect of pentobarbital on cerebral ischemia seems to be correlated to its action of improving disorders of NE, DA and 5 -HT in ischemic brain.
p均
p 16
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