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cox鄄
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  cox-2
     The expression rates of COX-2 and CD44v6 were 66.7%(44/66) and 74.3%(49/66), respectively.
     [结果]喉癌组织中COX鄄2及CD44v6蛋白表达阳性率分别是66.7%(44/66)、74.3%(49/66);
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     The positive expression rate of COX-2 was 46%,which had no correlation with lymph metastasis and differentiation degree,and was positively correlated with the expression of MMP-2 and MMP-9 protein(P=0.010 and 0.018).
     COX鄄2蛋白在舌鳞癌组织中的阳性率为46%,其表达与淋巴结转移及分化程度无关,但与MMP鄄2和MMP鄄9蛋白的表达均呈正相关(P=0.010和0.018)。
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     The high expressions of COX-2 and CD44v6 were correlated with lymph node metastasis and clinical staging(P<0.05), not correlated with age and sex(P>05).
     COX鄄2及CD44v6蛋白的高表达与喉癌的临床分期、淋巴结转移均呈正相关(P<0.05),与年龄性别无关(P>0.05);
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     To explore the expression and clinical significance of COX-2, CD44v6 in laryngeal carcinoma.
     [目的]探讨COX鄄2及CD44v6在喉癌中的表达及其临床意义。
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     [Conclusion] COX-2 and CD44v6 may be useful markers for predicting the biologic characteristics in laryngeal carcinoma.
     [结论]COX鄄2及CD44v6可作为预测喉癌临床生物学行为特征的标记物。
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  “cox鄄2”译为未确定词的双语例句
     Laryngeal carcinoma samples from 66 cases and nomal laryngeal tissues from 22 cases were studied by catalyzed signal amplification (COA) in situ hybridization and immunohistochemical technique(SP).
     [方法]应用催化信号放大原位杂交和免疫组化方法(SP法),对66例喉癌患者的手术新鲜标本进行COX鄄2及CD44v6蛋白表达检测,以22例癌旁正常组织作对照。
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  相似匹配句对
     2.RT-PCR was used to measure the mRNA levels of COX-2 and PPAR-y in HCC.
     结果显示COX2
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     A few rabbits were killed at 6h, 24h, 1W, 2W and 4W.
     B、COX2表达的影响
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     x~2-(?)
     x~2-(?)
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     2. Reviewing the academic history.
     2
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     Comparing Cox.
     Cox.
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  cox-2
Compounds 6c and e demonstrated preferential inhibition of the COX-2 isozyme at 10?μM.
      
Exposure of keratinocytes (HaCaT) to Cum-OOH for 18 h resulted in expression of COX-2 and increased levels of PGE2.
      
Inhibitors of COX-2 efficiently suppressed oxidative stress and enzyme expression in the cells treated with Cum-OOH.
      
These results suggest that COX-2-dependent oxidative metabolism is at least partially involved in Cum-OOH-induced inflammatory responses and thus tumor promotion.
      
COX-2 Inhibitors (Pairet, M., and van Ryn, J., eds., 2004, in Milestones in Drug Therapy, Parnham, M.
      
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Objectives:To evaluate the effects and mechanisms of action of celecoxib in inducing proliferation inhibition and apoptosis on human cholangiocarcinoma cell lines.Methods:The cyclooxygenase-2overexpressing human cholangiocar-cinoma cell line QBC939and cyclooxygenase-2-deficient human cholangiocarcinoma cell line SK-Cha-1was used for this study.The anti-proliferative effect was measured by using Methabenzthiazuron(MTT)assay;apoptosis was determined by transferase-mediated dUTP nick end labeling(TUNEL)detection...

Objectives:To evaluate the effects and mechanisms of action of celecoxib in inducing proliferation inhibition and apoptosis on human cholangiocarcinoma cell lines.Methods:The cyclooxygenase-2overexpressing human cholangiocar-cinoma cell line QBC939and cyclooxygenase-2-deficient human cholangiocarcinoma cell line SK-Cha-1was used for this study.The anti-proliferative effect was measured by using Methabenzthiazuron(MTT)assay;apoptosis was determined by transferase-mediated dUTP nick end labeling(TUNEL)detection and transmission electron microscope(TEM).Cell cycle was analyzed by using flow cytometry(FCM).The PGE 2 level in the supernatant of cultured cholangiocarcinoma cells was quantitated by enzyme-linked immunoabsordent assay(ELISA).Results:Celecoxib suppressed the production of PGE 2 and inhibited growth in QBC939cells;and the anti-proliferative effect of celecoxib can be abolished by addition of PGE 2 .Celecoxib induced proliferation inhibition and apoptosis by G 1 -S cell cycle arrest.The PGE 2 level is much lower constitutively in SK-Cha-1cells than that in QBC939cells,and celecoxib has no significantly influence on the SK-Cha-1cells.Conclusions:Cyclooxygenase-2specific inhibitor celecoxib inhibits proliferation and induces apoptosis of human cholangiocarcinoma cells via suppression of PGE 2 production in vitro.

目的:研究塞来昔布(celecoxib)对环氧合酶鄄2(COX鄄2)高表达人胆管癌细胞系QBC939和COX鄄2低表达人胆管癌细胞系SK鄄Cha鄄1生长和凋亡的影响及其作用机制。方法:采用四唑盐(MTT)比色法检测细胞增殖,光镜和电镜形态学观察,末端脱氧核苷酸转移酶介导的原位酶标记法(TUNEL)计数细胞凋亡,流式细胞仪测定细胞周期,酶联免疫吸附测定(ELISA)检测前列腺素E2(PGE2)含量。结果:塞来昔布抑制QBC939生长和诱导凋亡,这种抗增殖作用能被PGE2拮抗;塞来昔布对结构性低表达COX鄄2胆管癌细胞SK鄄Cha鄄1无显著性作用。结论:塞来昔布通过PGE2途径抑制人胆管癌细胞生长和诱导凋亡;针对COX鄄2结构性高表达肿瘤塞来昔布可能是一种有效的化学治疗和化学预防药物。

The current status and its variation trend of mortality rate of common malignancies in Guoyang county were investigated in order to establish preventive strategies for malignancies.Epidemiological retrospective survey and Cox-stuart's test were used to collect and analyze the data.The mortality rate of common malignancies in Guoyang county increased during the period of 1992 to 2001(P<0.05).The crude mortality rate was increased from 81.78 per 100 000(adjusted mortality rate 78.35 per 100 000) in 1992 to 150.93...

The current status and its variation trend of mortality rate of common malignancies in Guoyang county were investigated in order to establish preventive strategies for malignancies.Epidemiological retrospective survey and Cox-stuart's test were used to collect and analyze the data.The mortality rate of common malignancies in Guoyang county increased during the period of 1992 to 2001(P<0.05).The crude mortality rate was increased from 81.78 per 100 000(adjusted mortality rate 78.35 per 100 000) in 1992 to 150.93 per 100 000 (adjusted mortality rate 143.23 per 100 000) in 2001, with malignant tumor being the leading death cause. The mortality rate in female increased faster than that in male.The six leading malignancies of male in order were stomach cancer, hepatocarcinoma, lung cancer, esophageal carcinoma,bowel cancer and leukemia.Among them,the mortality with leukemia increasing ranked the rapidest.The mortality with esophageal carcinoma showed a slight decrease in males, but no significant difference was found(P>0.05).The six leading malignancies of female in order were stomach cancer,lung cancer,esophageal carcinoma,breast cancer,and cervix cancer.Among them the mortality rate with hepatocarcinoma increasing ranked the rapidest.The mortality with esophageal carcinoma and stomach cancer showed decreasing trend(P>0.05).[Conclusion]The mortality of common malignancies in Guoyang county presents the overall increasing trend during 1992~2001.The prevention and treatment should focus on stomach cancer, lung cancer, leukemia, hepatocarcinoma, bowel cancer,breast cancer and cervix cancer.

[目的]了解安徽省涡阳县恶性肿瘤死亡状况及趋势,为制订本地区肿瘤防治策略提供依据。[方法]采用流行病学回顾性调查法,由各村医生收集本村所有死亡病例上报,设计调查表入户调查;计算恶性肿瘤死亡率;用Cox鄄Stuart法分析其死亡趋势。[结果]1992年~2001年安徽省涡阳县的恶性肿瘤死亡率呈总体上升趋势(P<0.05),粗死亡率从81.78/10万(标化率为78.35/10万)上升至150.93/10万(标化率为143.23/10万),居死因首位。女性恶性肿瘤死亡率增长速度高于男性。男性恶性肿瘤死亡居前6位的分别是胃癌、肝癌、肺癌、食管癌、肠癌、白血病。其中白血病增速最快,其他依次为肠癌、胃癌、肺癌、肝癌;食管癌死亡率呈下降趋势,但未见显著性(P>0.05)。女性恶性肿瘤死亡居前6位的分别为胃癌、肺癌、食管癌、肝癌、乳腺癌、宫颈癌。其中肝癌增速最快,其他依次为宫颈癌、肺癌、乳腺癌。食管癌死亡率呈下降趋势。胃癌死亡率呈下降趋势,但无显著性(P>0.05)。[结论]安徽省涡阳县1992年~2001年恶性肿瘤死亡呈总体上升趋势,胃癌、肺癌、白血病、肝癌、肠癌、女性乳腺癌、宫颈癌为防治的重点。

Background: Expression of cyclooxygenase(COX)-2can be detected in the hepatocellular carcinoma(HCC).Aspirin,a non-steroidal anti-inflammatory drug,can inhibit the growth of HCC probably through the inhibition of COX-2expression.Aims:To compare the effects of three kinds of selective COX-2inhibitors(meloxicam,celecoxib and rofecoxib)on the growth of human liver cancer cell line SMMC-7721,and to observe the effect of rofecoxib,a highly selective COX-2inhibitor,on the growth of HCC implanted in the liver of nude...

Background: Expression of cyclooxygenase(COX)-2can be detected in the hepatocellular carcinoma(HCC).Aspirin,a non-steroidal anti-inflammatory drug,can inhibit the growth of HCC probably through the inhibition of COX-2expression.Aims:To compare the effects of three kinds of selective COX-2inhibitors(meloxicam,celecoxib and rofecoxib)on the growth of human liver cancer cell line SMMC-7721,and to observe the effect of rofecoxib,a highly selective COX-2inhibitor,on the growth of HCC implanted in the liver of nude mice.Methods:The DNA synthesis of SMMC-7721cells was determined by 3 H-thymidine( 3 H-TdR)incorporation method.The expression of proliferating cell nuclear antigen(PCNA)was detected by immunocytochemistry.The terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling(TUNEL)assay was used to detect cell apoptosis.Rofecoxib(30mg/kg per day)was administered to HCC implanted nude mice for eight weeks,the volume and weight of the xenografts in situ were measured.Results: Meloxicam,celecoxib and rofecoxib could decrease the 3 H-TdR incorporation significantly in a dose-dependent manner in SMMC-7721cells.Their50%inhibitory concentration(IC 50 )were8.55×10 -8 mol/L,1.22×10 -8 mol/L and6.27×10 -9 mol/L,respectively.After treated with the above three selective COX-2inhibitors(1×10 -5 mol/L)for24hours,the expression of PCNA in SMMC-7721cells were decreased,and the apoptosis index was significantly increased compared with that of the controls(14.6%±2.8%,21.6%±3.6%and27.1%±3.5%vs.1.0%±0.7%,P<0.01).The higher the selectivity of COX-2,the higher the apoptosis index(P<0.01).The xenografts in situ in nude mice treated with rofecoxib were significantly smaller than those of the controls,and the inhibition rates were73.2%in volume and78.1%in weight. Conclusions:All three kinds of selective COX-2inhibitors can effectively inhibit the growth of SMMC-7721cells in vitro in proportion to their selectivity. The inhibition of HCC growth in vivo by rofecoxib suggests it may be an effective drug in the treatment of HCC.

背景:肝细胞癌(HCC)中有环氧合酶(COX)鄄2表达,非甾体抗炎药阿司匹林可能通过抑制COX鄄2的表达而抑制HCC生长。目的:比较3种选择性COX鄄2抑制剂美洛昔康、赛来昔布和罗非昔布对人肝癌细胞株SMMC鄄7721生长的影响,观察高选择性COX鄄2抑制剂罗非昔布对裸鼠HCC原位移植瘤生长的影响。方法:采用3H鄄胸腺嘧啶核苷(3H鄄TdR)掺入检测SMMC鄄7721细胞的DNA合成情况;采用免疫细胞化学染色检测增殖细胞核抗原(PCNA)的表达;采用DNA原位末端标记(TUNEL)染色检测细胞凋亡。给予HCC原位移植瘤裸鼠罗非昔布每日30mg/kg8周,测量肿瘤体积和重量。结果:美洛昔康、赛来昔布和罗非昔布均能显著抑制SMMC鄄7721细胞的3H鄄TdR掺入,其抑制作用呈剂量依赖性,50%抑制浓度(IC50)分别为8.55×10-8mol/L、1.22×10-8mol/L和6.27×10-9mol/L。3种选择性COX鄄2抑制剂(1×10-5mol/L)作用24h均可明显降低SMMC鄄7721细胞的PCNA表达,使细胞凋亡指数较对照组显著增高(14.6%±2.8...

背景:肝细胞癌(HCC)中有环氧合酶(COX)鄄2表达,非甾体抗炎药阿司匹林可能通过抑制COX鄄2的表达而抑制HCC生长。目的:比较3种选择性COX鄄2抑制剂美洛昔康、赛来昔布和罗非昔布对人肝癌细胞株SMMC鄄7721生长的影响,观察高选择性COX鄄2抑制剂罗非昔布对裸鼠HCC原位移植瘤生长的影响。方法:采用3H鄄胸腺嘧啶核苷(3H鄄TdR)掺入检测SMMC鄄7721细胞的DNA合成情况;采用免疫细胞化学染色检测增殖细胞核抗原(PCNA)的表达;采用DNA原位末端标记(TUNEL)染色检测细胞凋亡。给予HCC原位移植瘤裸鼠罗非昔布每日30mg/kg8周,测量肿瘤体积和重量。结果:美洛昔康、赛来昔布和罗非昔布均能显著抑制SMMC鄄7721细胞的3H鄄TdR掺入,其抑制作用呈剂量依赖性,50%抑制浓度(IC50)分别为8.55×10-8mol/L、1.22×10-8mol/L和6.27×10-9mol/L。3种选择性COX鄄2抑制剂(1×10-5mol/L)作用24h均可明显降低SMMC鄄7721细胞的PCNA表达,使细胞凋亡指数较对照组显著增高(14.6%±2.8%、21.6%±3.6%和27.1%±3.5%对1.0%±0.7%,P<0.01),COX鄄2抑制剂的选择性越高,凋亡指数也越高(P<0.01)。罗非昔布组裸鼠的HCC原位移植瘤显著小于对照组,体积抑瘤率和重量抑瘤率分别为73.2%和78.1%。结论:3种选择性COX鄄2抑制剂均能在体外有效抑制SMMC鄄7721细胞的生?

 
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