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阿尔茨海默病患者
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  alzheimer ' s disease
     Analysis of the interaction of the-1385A/G polymorphisms of FGF1 gene promoter and ApoE gene in Alzheimer's disease
     阿尔茨海默病患者FGF1基因启动子-1385A/G多态与ApoE基因多态关联性分析
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     The accumulation of α7nAChR and the relationship between α7nAChR and Aβ_(1-42) in Alzheimer's disease brains
     α7烟碱型乙酰胆碱受体在阿尔茨海默病患者脑中的沉积及与Aβ_(1-42)的关系
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     p75~(NTR) expression in the CA1 subfield of human hippocampus and its relation to the pathogenesis of Alzheimer's disease
     阿尔茨海默病患者海马CA1区p75~(NTR)的表达与其神经病理学改变的关系
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     Characters and proportion of alphα_2-macroglobulin gene mutation in patients with sporadic Alzheimer's disease in China
     中国散发性阿尔茨海默病患者α_2-巨球蛋白基因突变特点及比例
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     PEN-2 gene mutation in a familial Alzheimer's disease case
     家族性阿尔茨海默病患者的PEN-2基因突变
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  “阿尔茨海默病患者”译为未确定词的双语例句
     Investigation of tau, Aβ_( 1-40 ) and Aβ_(1-42(43)) proteins in patients with Alzheimer disease and their clinical significance
     阿尔茨海默病患者脑脊液tau、Aβ_(1-40)、Aβ_(1-42(43))蛋白的检测及其临床意义
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     After treatment with Vitamin B1,the scores of HDS-R,FAQ and ADL in 20 AD patients were not remarkably ameliorated(14.39±5.41,24.20±3.82,12.65±7.43;14.42±6.04,23.87±5.17,11.86±6.09,P > 0.05).
     20例对照组阿尔茨海默病患者经维生素B1治疗后修订长谷川量表、精神认识能力评分及社会活动功能调查评分均无明显改善(14.39±5.41,24.20±3.82,12.65±7.43;14.42±6.04,23.87±5.17,11.86±6.09,P>0.05)。
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     Results Genotype frequency of GG,GC and CC were 16.39%,50.82% and 32.79%in patients with AD and 26.03%,41.10% and 32.87% in control subjects.
     结果在阿尔茨海默病患者中GG,GC和CC基因型频率分别为16.39%,50.82%和32.79%; 正常对照组中分别为26.03%,41.10%和32.87%。
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     Association between cytochrome P450 1A1 gene and apolipoprotein E gene polymorphisms in patients with Alzheimer disease
     阿尔茨海默病患者细胞色素P4501A1基因与载脂蛋白E基因多态性的关联分析
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     Methods: The gene polymorphisms of apoE、IL-1α、TNF-αand IL-1ra genotype were examined in 55 AD cases and 59 controls by means of polymerase chain reaction(PCR) and restriction fragment length polymorphism (RFLP).
     方法:随机选取55名阿尔茨海默病患者和59名对照人群,用PCR(聚合酶链式反应)和RFLP(限制性片段长度多态性)方法,分析受检者的载脂蛋白E(APOE)、IL-lα、TNF-α和IL-1Ra VNTR的基因型。
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  相似匹配句对
     Impaired insight of patients with Alzheimer disease
     阿尔茨海默患者的自知力损害
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     Characteristics of eventrelated potentials in patients with Alzheimer disease
     阿尔茨海默患者事件相关电位的特征
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     Executive dysfunction in Alzheimer's disease
     阿尔茨海默患者的执行功能障碍
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     The analysis of apolipoprotein E geng genotype of patients with Alzheimer's Disease
     阿尔茨海默患者载脂蛋白E基因型分析
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     Polymorphism of Apolipoprotein E Allele with Alzheimer Disease
     阿尔茨海默患者载脂蛋白E等位基因的多态性
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  alzheimer ' s disease
Furthermore, acetylcholinesterase and butyrylcholinesterase inhibitors such as tacrine, donepezil, rivastigmine, and galantamine are currently used to manage Alzheimer's disease.
      
Since amlodipine besylate is a very potent inhibitor of both cholinesterases, amlodipine besylate may, like donepezil, be useful in Alzheimer's disease treatment.
      
Mutations in presenilin 1 (PS1) gene are closely associated with the early onset of familial Alzheimer's disease (EOFAD).
      
Prospects of Non-drug Approaches to Alzheimer's Disease
      
According to the immune status indices and our previous data on behavioral, biochemical, and morphological changes induced in bulbectomized mice, they have common symptoms with the Alzheimer's disease.
      
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Objective To observe the expressions of CD44 antigen in the brains of the patients with Alzheimer disease (AD) and non dementia (ND) and to reveal the role of CD44 in the pathogenesis of AD. Methods Using immunohistochemistry (IHC) technology, we checked up the expression of CD44 and β amyloid protein (β AP) in the cerebral cortexes, hippocampi and cerebellums of 11 cases of postmortem autopsy brain tissues.Among them, there were 5 cases of AD and 6 cases of ND. Results CD44 was specifically...

Objective To observe the expressions of CD44 antigen in the brains of the patients with Alzheimer disease (AD) and non dementia (ND) and to reveal the role of CD44 in the pathogenesis of AD. Methods Using immunohistochemistry (IHC) technology, we checked up the expression of CD44 and β amyloid protein (β AP) in the cerebral cortexes, hippocampi and cerebellums of 11 cases of postmortem autopsy brain tissues.Among them, there were 5 cases of AD and 6 cases of ND. Results CD44 was specifically expressed in the astrocytes in white matters of the 11 brains. There were a lso some expressions of CD44-positive astrocytes in the gray matters of the AD cases. The expressions of CD44 in AD were significantly stronger than those in ND ( P < 0.01). In AD, the expressions of CD44 of the cerebral cortexes and hippocampi were stronger than those of the cerebellums ( P <0.01). There was correlation between the positive degrees of β AP and CD44 in the brains of AD ( r =0.679), but significant difference existed in the distributions of them. Conclusion The CD44-positive astrocytes might participate in the pathogenesis of AD.

目的观察CD44阿尔茨海默病患者(AD)抗原在非痴呆老年人(ND)及脑内的表达,揭示CD44与AD病理机制之间存在的关系。方法采用免疫组织化学(IHC)方法检测CD44、β淀粉样蛋白(βAP)在5例AD,6例ND大脑皮层、海马、小脑等部位的表达。结果发现CD44在11例脑内白质的部分星形胶质细胞上存在特异性表达,但在AD皮层的灰质也存在一些表达;AD组与ND组相比,CD44阳性度明显增加(P<0.01)。在AD组,新皮层、海马较小脑等部位的CD44表达增强(P<0.01);AD组脑内CD44阳性度与βAP阳性度存在相关(r=0.679),但两者阳性区分布欠一致。结论CD44阳性度星形胶质细胞可能参与AD的病理机制。

Objective To present a rapid, sensitive and safe procedure for the determination of human apolipoprotein E alleles.Methods Genomic DNA was extracted from 0.5ml whole blood by a non phenol protocol. After PCR and restriction enzyme digestion,short DNA fragments were detected by a simplified silver staining method. This technique was used to assay apolipoprotein E alleles in 19 patients with sporadic Alzheimer's disease and 41 normal aged persons. Results The short DNA fragments were visualized clearly on polyacrylamide...

Objective To present a rapid, sensitive and safe procedure for the determination of human apolipoprotein E alleles.Methods Genomic DNA was extracted from 0.5ml whole blood by a non phenol protocol. After PCR and restriction enzyme digestion,short DNA fragments were detected by a simplified silver staining method. This technique was used to assay apolipoprotein E alleles in 19 patients with sporadic Alzheimer's disease and 41 normal aged persons. Results The short DNA fragments were visualized clearly on polyacrylamide gel processed by silver staining. It took 24 hours from DNA extraction to the final result. The ε4 allele frequency in patients with sporadic Alzheimer's disease was 0.29, much higher than that in control group (0.02, P<0.001) . Conclusion PCR in combination with silver staining can satisfy the need for high resolution and high effciency in the determination of apolipoprotein E alleles and can be used as a routine procedure in clinical and epidemiological investigations.

目的介绍一种高效、灵敏、安全的载脂蛋白E等位基因检测法。方法采用非酚法快速提取人全血基因组DNA,PCR扩增包含两个等位基因决定位点的DNA片段,扩增产物经限制性酶切后进行聚丙烯酰胺凝胶电泳,用简易银染法显示酶切片段。结果银染显示出清晰易辨的DNA酶切小片段,整个检测过程24小时完成。将此法初步用于19例散发性阿尔茨海默病患者和41名无精神神经疾患老年人载脂蛋白E等位基因的检测,测得ε4等位基因频率分别为0.29和0.02,两者之间差异非常显著(P<0.001)。结论PCR结合银染法检测载脂蛋白E等位基因,在尽量避免使用有害试剂的同时,提高了检测灵敏度和效率,因此适用于临床及流行病学调查时对大批标本的检测

Objectives\ To observe whether the patients with Alzheimer's disease(AD)or vascular dementia(VaD)have disorders in non-cognitive function besides cognitive disorders.Methods\ All of the patients came from the special ward for dementia in Department of Neurology.21 patients with AD and 25 patients with VaD were studied according to the standard of DSM-Ⅳ.The degree of dementia was mild to moderate based on CDR.The symptoms of non-cognitive function disorders include emotional disturbance,behavior changes,personality...

Objectives\ To observe whether the patients with Alzheimer's disease(AD)or vascular dementia(VaD)have disorders in non-cognitive function besides cognitive disorders.Methods\ All of the patients came from the special ward for dementia in Department of Neurology.21 patients with AD and 25 patients with VaD were studied according to the standard of DSM-Ⅳ.The degree of dementia was mild to moderate based on CDR.The symptoms of non-cognitive function disorders include emotional disturbance,behavior changes,personality alterations and disturbance of perception.Results\ The AD group had more severe emotional disturbance(16,76%),personality alterations(10,48%)and disturbance of perception(6,29%)than VaD group (10,40%;1,4%;and 1,4%,respectively).Conclusions\ Patients with dementia not only have disorders in cognitive function,but also have impairment of non-cognitive function.There were more severe damages of non-cognitive function in AD than VaD,which may be related to the different pathological mechanism.

目的 观察阿尔茨海默病与血管性痴呆的患者除认知功能异常外 ,是否存在非认知功能的异常。方法 根据DSM -Ⅳ阿尔茨海默病及血管性痴呆的诊断标准以及CDR的临床痴呆分级标准 ,对神经内科老年记忆障碍专科病房的 2 1例轻中度阿尔茨海默病及 2 5例血管性痴呆患者的非认知功能损害的临床表现进行了观察 ,包括情感反应、行为异常、人格变化及知觉异常。结果 阿尔茨海默病患者的非认知功能损害在情感障碍 (16例 ,76 % )、人格异常 (10例 ,48% )及知觉异常 (6例 ,2 9% )方面 ,明显多于血管性痴呆组 (分别为 10例 ,40 % ;1例 ,4% ;1例 ,4% )。结论 痴呆患者不仅有认知功能的损害 ,还有非认知功能的损害。阿尔茨海默病的非认知功能损害重于血管性痴呆 ,可能与两种痴呆的发病机制不同有关。

 
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