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剂量
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  dose
     the mean dose were 66.2 Gy、66.3 Gy、68.1 Gy .
     平均剂量(Dmean)分别为66.3Gy、66.4Gy、68.2Gy。
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     and the minimum dose were63 Gy、61.5 Gy、61.7 Gy ;
     最小剂量(Dmin)分别为63 Gy、61.5 Gy、61.8 Gy;
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     The average initial dose of risperidone was (0.72±0.26) mg·d-1 , po, the average therapeutic dose, (1. 58 ± 0. 83) mg· d-1 , po.
     利培酮的平均起始剂量为(0.72±0.26)mg·d-1,平均治疗剂量(1.58±0.83)mg·d-1。
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     WMSI of CAD at baseline(b)was1.36±0.21(P<0.001),at low dose(l)was1.17±0.16(P<0.001),at peak dose(p)was1.48±0.20(P<0.05).
     CAD组WMSI静息(b)、小剂量(l)、大剂量(p)时分别为1.36±0.21(P<0.001),1.17±0.16(P<0.001),1.48±0.20(P<0.05)。
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     The average dose of MMF was(1.2±0.3)g/d.
     MMF平均剂量(1.2±0.3)g/d。
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  “剂量(”译为未确定词的双语例句
     Clinical study of effectiveness with low-dosage(5mg) simvastatin on aged hyperlipidemic patents
     小剂量(5mg)舒降之(Simvastatin)对老年人调脂作用的临床研究
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     however,0.03 mg/kg spermidine treatment,first statistically decreasing the mRNA level in the 2 hours after PH,promoted the increase in ODC mRNA at the 4(th) and 6(th) hours after PH respectively.
     而低剂量(0.03 mg/kg体重)处理组则不同,ODC mRNA水平表现出先抑制(在2h)后促进(在4h和6h)的特点。
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     Methods Fifty mice were randomly divided into 5 groups,normal control group(A group),irradiated control group(B group) and 3 EGP treatment groups(C,D,E groups). C,D,E groups were fed with EGP 100,200,400 mg·kg-1·d-1 respectively for 10 days,and A,B groups were fed with equal volume of physiological saline.
     方法将50只小鼠随机分为正常对照组(A组)、辐射对照组(B组)和3个不同剂量EGP+辐射组(C、D、E组),C、D、E组分别以3个不同剂量(100、200和400mg.kg-1.d-1)按每10 g体质量0.1 mL灌胃,连续10 d;
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     Methods:Under serum free culture media, MSCs were incubated with different doses of EP for 24 h(0, 0.25, 0.5, 1, 2, 10 U/ml), and then the proliferation of MSCs was measured by MTT assay.
     方法:无血清条件下,不同剂量(0,0.25,0.5,1,2,10U/ml)EP与MSCs共培养24h,MTT方法检测MSC增殖情况;
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     Method In this subacute toxicity study,the experimental mice were forced to inhale the bitumen fumes at different exposure levels(55 mg/m3?165 mg/m3)and different time periods(30 d?60 d). H.
     方法建立染毒小鼠模型,进行不同剂量(55、165 mg/m3)和不同时间(30 d、60 d)染毒,光镜下观察肺组织形态改变;
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  相似匹配句对
     (4)closage of shocks;
     (4)电击剂量;
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     CT Dose Problem
     CT的剂量问题
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     Discussion about the Dosage Regimen for the Senile Patient
     老年人用药剂量的商榷
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     Thedefinition of mole absorbed dose B is B=(d(?)
     摩尔吸收剂量 B 定义为(d(?)
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  dose
Studies in rats revealed dose dependency/ non-linearity in arteether pharmacokinetics with in the dose levels used.
      
In this study, we find that prodigiosin could effectively inhibit the proliferation of human pancreatic cancer cells H8898 in a dose-and-time-dependent manner, with an IC50 of 75μmol according to the results of MTT and cell proliferation assays.
      
Prodigiosin may effectively enter cells and promote the level of intracellular reactive oxygen species (ROSin) in a dose-dependent manner.
      
Doses ranging from 12.5-50 μM provided a dose-dependent reduction in the number of viable cells when compared to controls.
      
At the 50 μM dose, the number of viable cells was reduced by 65% suggesting potential antineoplastic effects of 9-O-methylfusarubin.
      
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A new method for the biological assay of vegetable purgatives based on the numbers of wet faeces excreted by groups of mice after dosing is described. The relation of the number of wet faeces per group of mice to the logarithm of the dose was found to be linear. A cage has been specially designed for this assay and it has been found advantageous to incorporate a definite proportion of water in the diet during test. 40 mice divided equally into 4 groups were used in each assay. 2 groups received the standard...

A new method for the biological assay of vegetable purgatives based on the numbers of wet faeces excreted by groups of mice after dosing is described. The relation of the number of wet faeces per group of mice to the logarithm of the dose was found to be linear. A cage has been specially designed for this assay and it has been found advantageous to incorporate a definite proportion of water in the diet during test. 40 mice divided equally into 4 groups were used in each assay. 2 groups received the standard preparation and the other 2 groups received the test preparation. The standard deviation of a single determination based on 9 such assays was estimated to be 15.7 per cent. For rhubarb and its preparations, a“6-point”assay is advocated. With suitable restric-tion in the design of the assay, it is possible to calculate the potency by simple methods. Powdered crude drugs are used as laboratory standards in the assay of senna and rhubarb. The doses of cascara bark required to produce distinctive responses are too inconveniently large to be administered in suspension. It was found possible to use a potent extract of cascara in place of the powdered bark as a laboratory standard. Examples of the assay and the subsequent calculations are given. The method described is not only convenient in use but also gives a comparatively high degree of accuracy. The method has been successfully applied to senna leaf, senna fruit, rhubarb, cascara sagrada and extracts and commercial preparations made from these drugs, pure glycosides(sennosides A and B) and pure anthracene compounds(aloe emodin and aloe-emodine anthranol).

(1)本文详述植物性泻药的一种新的生物测定法,此法係用小白鼠在服药后所排出的濕粪数为基础,以定泻药的效价。(2)小白鼠服药後所排出的湿粪数与剂量指数的关係经证明为一直线。(3)本法所用鼠笼係特别设计,并证明在饲料内加入一定量的饮水,具有多种优点。(4)番泻效价的测定,每次用小白鼠4组,每组10只。2组给与标准品,另外2组给与试验品。根据9次试验的结果,试验的标准差是15.7%.(5)大黄效价的测定,以采用“6点”法为宜,即每次试验用小白鼠6组,3组给与标准品,另外3组给与试验品,所得的准确度与上述相仿。波希鼠李皮浸膏的效价测定,则用“4点”法或“6点”法均可。(6)所有试验一律采用粉状生药为实验室的比较标准,但是波希鼠李皮的效价太低,它的粉末不适於作为标准之用,可用波希鼠李皮乾浸膏来代替,作为比较标准。(7)本文对於效价测定及其计算方法都举例说明,并介绍了比较常法为简捷的相关效价计算法。(8)本法不但方便易行,而且有相当高的准确度;曾用在番泻、大黄、波希鼠李皮及其制剂,以及一些纯粹的蒽醌衍生物的效价测定,都获得了满意的结果。

A series of 8 new compounds with the dithia-dihydrostibiol structure has been compared for the therapeutic activities against schistosomiasis japonica in white mice. Each drug, thoroughly mixed with the finely powdered food, was fed to healthy mice for 14 days, and the LD_(10) and LD_(50) were evaluated. At the dosages of LD_(10) and LD_(50), each drug was fed to treat diseased mice (beginning on the 36th day after percutaneous infection on abdomen with 40 cercariae per mouse) for 14 days. After a holding period...

A series of 8 new compounds with the dithia-dihydrostibiol structure has been compared for the therapeutic activities against schistosomiasis japonica in white mice. Each drug, thoroughly mixed with the finely powdered food, was fed to healthy mice for 14 days, and the LD_(10) and LD_(50) were evaluated. At the dosages of LD_(10) and LD_(50), each drug was fed to treat diseased mice (beginning on the 36th day after percutaneous infection on abdomen with 40 cercariae per mouse) for 14 days. After a holding period of another 14 days mice were killed. Both portal system and liver were carefully scrutinized for worms. Basing on the average number of worms remained in each mouse, the therapeutic effects of out of the 8 compounds were better than that of tartar emetic administered orally.

用小白鼠试验8种二硫锑五环化合物,在同一毒性水平上比较对於日本血吸虫病的疗效。每种药物与饲料粉混匀喂饲健康小鼠14天,求出LD_(10)及LD_(50)。以这两个剂量,分别治疗病鼠(每鼠腹部皮肤感染40条尾蚴,5周後开始给药)14天,然後停药14天解剖,详细检查门静脉系统与肝内的余存虫。根据平均每鼠余存虫数,以吐酒石为标准,比较各药的疗效。结果发现Sb-1及Sb-19口服疗效较吐酒石为优。

(1) White mice were exposed to 40 cercariae of Schistosoma japonicum on the abdomen for 3, 5, 10, 15 and 20 minutes. Five weeks later, mice were killed and searched for worms. The percentage of worms recovered in the 5-minute group was found to be low (33%), whereas the differences between those in the 10-minute (45%), 15-minute (51%) and 20-minute (54%) groups were non-significant. (2) Infected mice were treated with tartar emetic given by mouth for 2 weeks. After a holding period of 1, 2, 3 or 4 weeks, mice...

(1) White mice were exposed to 40 cercariae of Schistosoma japonicum on the abdomen for 3, 5, 10, 15 and 20 minutes. Five weeks later, mice were killed and searched for worms. The percentage of worms recovered in the 5-minute group was found to be low (33%), whereas the differences between those in the 10-minute (45%), 15-minute (51%) and 20-minute (54%) groups were non-significant. (2) Infected mice were treated with tartar emetic given by mouth for 2 weeks. After a holding period of 1, 2, 3 or 4 weeks, mice were sacrificed. The differences between the number of worms remained in the 4 groups of mice were non-significant. Therefore, one week may be adopted as the holding period in the screening test for antimonials. (3) In the control group and in the treated group with tartar emetic 270 mg/kg/day, there was no significant difference between the number of worms remained in male and in female mice. But in the treated group with tartar emetic 170 mg/kg/day, the number of worms remained in female mice was less than that in male mice. Hence it is advisable to use equal number of both sexes of mice in experimental therapy. (4) After the treatment with tartar emetic, mice were divided into 2 grades according to the body weights. The number of worms remained in mice of the 2 grades revealed a significent difference only in the group with holding period of 3 weeks, but not in other groups.

(一)小白鼠腹部皮肤感染40条日本血吸虫尾蚴,感染时间自3至20分钟不等,5周後解剖,检查成虫数,发现感染尾蚴5分钟的成虫发育率较低(33%),而感染10分钟(45%),15分钟(51%)及20分钟(54%)之差别不显著。 (二)病员经口服吐酒石治疗2周後停药1,2,3或4周解剖,发现余存虫数之差别并不显著。所以可用1周作为比较锑剂疗效试验的停药时间。 (三)对照组及吐酒石270毫克/千克/天剂量组内,雌雄鼠体内余存虫数相差不显著,但在吐酒石1700毫克/千克/天治疗组内,雌鼠体内的余存虫数少於雄鼠体内的虫数。所以实验治疗所用的小白鼠最好是雌雄各半。 (四)吐酒石治疗後大小两级体重鼠体内余存虫数,仅在停药3周组内有显著的差别:其他组内则未见显著差别。

 
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