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   诱导凋亡作用 的翻译结果: 查询用时:0.019秒
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诱导凋亡作用
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  apoptotic effect
     Comparison of Apoptotic Effect between BT325 Human Glioblastoma and U251 Glioblastoma Inducted by FasL Gene Transferred NIH3T3 Fibroblast
     FasL基因转染NIH3T3细胞对BT325和U251胶质瘤细胞诱导凋亡作用的比较
短句来源
     When the concentration of TGZ was less than 15 μmol/L,the apoptotic effect was found to be weak.
     用TGZ刺激SW-480细胞后48 h测细胞凋亡时发现,TGZ浓度低于15μmol/L时,TGZ对SW-480细胞诱导凋亡作用弱。
短句来源
     Apoptotic effect of oridonin on NB4 cells and its mechanism。
     冬凌草甲素对白血病NB4细胞的诱导凋亡作用及其机制(英文)
短句来源
     Apoptotic effect of oridonin on HL-60 cells and its mechanism
     冬凌草甲素对HL-60细胞的诱导凋亡作用及其作用机制(英)
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     The apoptotic effect was prominent when the concentration exceeded 20 μmol/L.
     TGZ浓度≥20μmol/L时,诱导凋亡作用明显,与未加药组比较差异有统计学意义。
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  “诱导凋亡作用”译为未确定词的双语例句
     Recently,many investigations have demonstrated that E2F-1 has an apparently unique capability to induce apoptosis,and its functions relate to P53、P73、APAF-1、Caspase3 、Caspase7、BcL-2 family members、DIP、SIVA 、NF-κB factor and so on.
     近年来,许多研究表明E2F-1具有特异性地诱导细胞凋亡的功能,其诱导凋亡作用与P53、P73、APAF-1、CASPASE-3、CASPASE-7、BCL-2家族、DIP、SIVA和NF-κB等因子有关。
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     Apoptosis of K562 Cell and Multidrug Resistant Cells(K562/vin,K562/dox) Induced by Matrine
     苦参碱对K562及其多药耐药细胞K562/vin、K562/dox的诱导凋亡作用
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     Apoptosis of γδT cells and αβT cells induced by ceramide
     神经酰胺对人γδT细胞和αβT细胞的诱导凋亡作用
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     ②After treated with G Rh 2 of 4μmol/L for 72 h,the most significant apoptosis effect on C 6 cells was induced.
     2 Rh2 作用 72 h后 ,4μmol/L浓度对 C6胶质瘤细胞诱导凋亡作用最为明显 ;
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     Inhibition of Proliferation and Induction of Apoptosis by Tanshinone ⅡA in NCI-H460 Cell
     丹参酮ⅡA对NCI-H460肺癌细胞的增殖抑制和诱导凋亡作用
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  相似匹配句对
     Finally, lead to the articular cartilage
     诱导软骨细胞凋亡
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     Malignant glioma cells apoptosis induced by sea anemones (Phyllodiscus semoni) venom
     海葵毒素对神经胶质瘤细胞的凋亡诱导作用
短句来源
     Tumor Cell's Apoptosis Induced by Arsenics
     砷剂对肿瘤细胞的诱导凋亡作用
短句来源
     He as gas source can induce the apoptosis of tumor in this model.
     He 气腹有诱导肿瘤凋亡作用
短句来源
     Function of apoptosis induced by derivatives of retinoid acid on tumor cells
     维甲酸衍生物对肿瘤细胞的凋亡诱导作用
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  apoptotic effect
Class-specific pro-apoptotic effect of statins on human vascular endothelial cells
      
Ceramide has been shown to be a key signaling molecule involved in the apoptotic effect of tumor necrosis factor α (TNF-α) and other cytokines.
      
These results indicate that resveratrol seems to exert its growth-inhibitory/apoptotic effect on the breast cancer cell line MCF7 via the Akt-caspase-9 pathway.
      
The apoptotic effect of TNF was significantly inhibited in the MT-overexpressing cardiomyocytes.
      
Corresponding to the apoptotic effect, TNF at 10 ng/mL caused rapid phosphorylation of p38 MAPK in wild-type cardiomyocytes.
      
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IM: To examine whether oxidized low density lipoproteins (ox LDL) might induce apoptosis in bovine aortic and endocardial endothelial cells (BAEC and BEEC). METHODS: Low density lipoproteins (LDL) were isolated from healthy human plasma by ultracentrifugation and oxidized by CuSO 4 10 μmol·L -1 . BAEC and BEEC were incubated in a medium containing ox LDL, LDL, or phosphate buffer solution (PBS) as control. DNA fragmentation was visualized by agarose gel electrophoresis and determined quantitatively...

IM: To examine whether oxidized low density lipoproteins (ox LDL) might induce apoptosis in bovine aortic and endocardial endothelial cells (BAEC and BEEC). METHODS: Low density lipoproteins (LDL) were isolated from healthy human plasma by ultracentrifugation and oxidized by CuSO 4 10 μmol·L -1 . BAEC and BEEC were incubated in a medium containing ox LDL, LDL, or phosphate buffer solution (PBS) as control. DNA fragmentation was visualized by agarose gel electrophoresis and determined quantitatively using Hoechst 33258 fluorochrome. RESULTS: Ox LDL, not LDL, elicited typical apoptotic changes and DNA fragmentation in BAEC and BEEC. In BAEC, dextran sulfate, and cicloheximide (Cic) exhibited no effect on DNA fragmentation induced by ox LDL. Butylated hydroxytoluene (BHT) 20 μmol·L -1 completely inhibited Cu 2+ mediated oxidation of LDL as well as the apoptosis inducing effect of Cu 2+ exposed LDL. Lysophosphatidylcholine (LPC) did not elicit DNA fragmentation in BAEC and in BEEC. DNA fragmentation induced by ox LDL in BAEC and in BEEC was blocked by chelating the calcium of the culture medium by egtazic acid. CONCLUSION: Ox LDL induces apoptosis in BAEC and BEEC without involving the LPC.)

目的:研究氧化型低密度脂蛋白(oxLDL)诱导血管和心内膜内皮细胞凋亡.方法:用超速离心法分离健康人血浆低密度脂蛋白(LDL),以CuSO410μmol·L-1氧化.观察oxLDL对培养新生小牛主动脉内皮细胞及心内膜细胞的损伤作用.琼脂糖凝胶电泳和Hoechst33258荧光密度法定性与定量分析DNA降解.结果:oxLDL诱导血管内皮细胞及心内膜细胞典型凋亡形态学改变,DNA降解呈时间和剂量依赖性.环己米特和硫酸葡聚糖对此作用无影响.BHT20μmol·L-1可取消DNA降解.溶血性磷脂酰胆碱50μmol·L-1无诱导凋亡作用.oxLDL诱导的DNA降解可被依他酸取消.结论:oxLDL诱导血管内皮细胞及心内膜细胞凋亡.

To study taxo1-induced apoptosis and growth inhibition in human esophageal carcinoma cells. Methods: MTT assay, cell morphology, agarose gel electrophoresis, and flow cytometry were used to examine taxol-induced apoptosis and growth inhibition in human esophageal carcinoma cell line Ecal09. Results: Taxol was cytotoxic to human esophageal carcinoma cells in a time-dependent manner and dose-dependent manner with a given range. The minimal effective concentration was 6 nmol/L. After treated with taxol, cells at...

To study taxo1-induced apoptosis and growth inhibition in human esophageal carcinoma cells. Methods: MTT assay, cell morphology, agarose gel electrophoresis, and flow cytometry were used to examine taxol-induced apoptosis and growth inhibition in human esophageal carcinoma cell line Ecal09. Results: Taxol was cytotoxic to human esophageal carcinoma cells in a time-dependent manner and dose-dependent manner with a given range. The minimal effective concentration was 6 nmol/L. After treated with taxol, cells at interphase and mitosis underwent apoptosis with typi-cal morphological feature and characteristic apoptotic feature at mitosis respectively. When cells were treated with taxol for 48 h,DNA ladder with agarose gel electrophoresis was observed, and the intensity of DNA ladder was enhanced in a dose- and time-dependent pattern. DNA fragment appeared in cells treated with 3 nmol/L taxol. Apoptotic program of cells treated with taxol can be initiated in short time. Sustained acting was unnecessary. DNA histograms by flow cy-tometric analysis displayed distinct apoptotic peak. Conclusion: The cytotoxic effect of taxol on human esophageal carcinoma cells resulted from taxol-induced apoptosis. This ability of inducing apoptosis may contribute to the clinical effect of taxol. Our results indicate that taxol has great potential for the treatment of esophageal carcinoma.

目的:研究紫杉醇对食管瘤细胞生长抑制及诱导凋亡的作用.方法;应用MTT分析法、形态学观察、琼脂糖凝胶电泳、流式细胞术等方法对紫杉醇诱导的食管癌细胞系Eca109进行了检测和观察.结果:紫杉醉在6 nmol.L浓度时对食管癌细胞就有显著的生长抑制作用,并且有时间依赖关系及一定范围的剂量依赖关系.凋亡可发生在细胞间期和分裂期,分别具有典型的凋亡形态特征及分裂期特有的凋亡特征.琼脂糖凝胶电泳显示紫杉醇作用48h便可出现DNA梯带,并呈时间剂量性增强.最低3 nmol/L浓度可见DNA梯带.紫杉醇可很快启动细胞凋亡的程序,并不需要持续作用.用流式细胞仪测定细胞周期,可见明显的凋亡峰.结论:紫杉醇对食管瘤细胞的细胞毒作用是诱导其凋亡的结果,这种诱导凋亡的能力是紫杉醇疗效的基础,因而在对食管瘤的治疗中紫杉醇有着巨大的潜力.

AIM To study paclitaxel-induced cell cycle block and apoptosis in human esophageal carcinoma cells. METHODS Cell morphology,agarose gel electrophoresis and flow cytometry were used to examine paclitaxel-induced cell cycle block and apoptosis in human esophageal carcinoma cell line Eca109. RESULTS Paclitaxel induced cell cycle block at G0/G1 and G2/M phases, and initiated apoptosis with typical morphological feature, apoptotic peak by flow cytometric analysis, cellnant fragmental DNA ladder bands by agarose gel...

AIM To study paclitaxel-induced cell cycle block and apoptosis in human esophageal carcinoma cells. METHODS Cell morphology,agarose gel electrophoresis and flow cytometry were used to examine paclitaxel-induced cell cycle block and apoptosis in human esophageal carcinoma cell line Eca109. RESULTS Paclitaxel induced cell cycle block at G0/G1 and G2/M phases, and initiated apoptosis with typical morphological feature, apoptotic peak by flow cytometric analysis, cellnant fragmental DNA ladder bands by agarose gel electrophoresis when cells were treated with 3 nmol·L-1 paclitaxel for 72 h. There were different morphological change and cell cycle change between cells treated with 100 nmol· L-1 and 1 000 nmol· L-1 concentration respectively. Additional incubation after removal of paclitaxel which had acted with cells for a short time (<2 h) induced apoptosis earlier than sustained incubation with paclitaxel. CONCLUSION Paclitaxel not only induces mitotic block, but also arrests cells at interphase. Cell cycle block may not be a sufficient signal for paclitaxel-induced apoptosis, and it may prolong the process of apoptosis. There may be several pathways for apoptosis in esophageal carcinoma cells.

目的研究紫杉醇对食管癌细胞的细胞周期阻断及诱导凋亡的作用。方法应用形态学观察、琼脂糖凝胶电泳、流式细胞术等方法对紫杉醇诱导的食管癌细胞系Eca109进行了检测和观察。结果紫杉醇可将食管癌细胞阻断于G0/G1期及G2/M期并诱导其凋亡,凋亡细胞具有典型的凋亡形态特征,流式细胞仪检测有凋亡峰出现,琼脂糖凝胶电泳显示3nmol·L-1紫杉醇作用72h便可见明显的DNA梯带。100nmol·L-1和1000nmol·L-1浓度的紫杉醇作用于细胞,在形态变化与细胞周期变化上有很大差别。紫杉醇作用短时间(<2h)去除后再培养比持续性作用更早促使细胞凋亡。结论紫杉醇不仅可以阻断食管癌细胞的分裂,而且对于间期细胞也有很大作用。细胞周期阻断并不直接诱导细胞凋亡,甚至可能抑制细胞凋亡的进程。食管癌细胞中存在多条凋亡途径。

 
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