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基因序列特征
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  gene sequence characteristics
     Gene Sequence Characteristics of HIV-1 CRF01-AE Subtype Viruses
     CRF01-AE亚型人类免疫缺陷病毒的基因序列特征研究
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  “基因序列特征”译为未确定词的双语例句
     Sequence analysis of gag-pol gene of HIV-1 B/C recombinant viruses in China
     中国HIV-1B/C重组病毒的gag-pol区基因序列特征分析
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     Methods: According to the principle of siRNA design,Smad2 specific siRNA(1-3) was designed and the keloid fibroblast were transfected.
     方法:根据siRNA设计原则,针对人Smad2 基因序列特征设计Smad2 特异siRNA(1 3),转染瘢痕疙瘩成纤维细胞,RT PCR检测siRNA对Smad2 基因的抑制效果。
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     2 The sequences of 18S rRNA and matK genes of Panax notoginseng from different localities are identified to genotype R1 and genotype M1 in GenBank (D85171 and AB027526), respectively.
     (2)不同产地的三七的核糖体18SrRNA和叶绿体matK基因序列特征完全一致,分别与GenBank上已报道的R1型(D85171)和M1型(AB027526)序列吻合。
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     Methods: Smad specific siRNA was designed and the keloid fibroblast were transfected.
     方法:根据siRNA设计原则,针对人Smad基因序列特征分别设计Smad2、Smad3特异siRNA,转染瘢痕疙瘩成纤维细胞;
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     Objective To study on the characters of HIV-1 Tat exon 1 amino acid sequence and mutations and the relationship with disease progression among HIV-1 infected people and AIDS patients.
     目的 研究HIV - 1感染者 /AIDS患者体内不同亚型HIV - 1tat基因序列特征、突变特点及与疾病进展的关系。
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     DNA Sequence Features of Transfusion Transmitted Virus in Neonatal Infection
     新生儿输血传播病毒感染及基因序列特征
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     Sequence characterization of Apxll toxin of Actinobacillus pleuropneumoniae
     胸膜肺炎放线杆菌Apxll毒素的基因序列特征
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     The Characteristic of Software
     软件的特征
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     (2)essential features;
     基本特征;
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     Gene Sequences
     基因序列(英文)
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The DNA sequence character,oxygen-regulation mode and mechanism of Vitreoscilla haemoglobin(VHb) gene were reviewed;the factors influencing stability and expression level of VHb recombinant plasmid,such as copy number, the direction and strength of VHb promoter were also discussed In addition, applications of VHb in some industrial microorganisms were introduced so as to indicate the bright future of application in fermentation industry.

介绍了透明颤菌(Vitreoscilla)血红蛋白(VHb)基因的序列特征、氧调控特性及调节机制,并探讨了VHb重组质粒的稳定性和表达水平的影响因素;还介绍了VHb在一些工业微生物中的应用情况,表明其在发酵工业中具有良好应用前景。

Concomitantchroniclymphocyticleukemia(CLL)andmultiplemyeloma(MM)isararedisease.Studiesontheclonaloriginofbothlymphocyteandplasmacelinthisdiseasehasbeenfew.SofarithasnotbeenreportedinChina.Thepaperreportsacaseof92-yearoldpatientwithconcomitantCLLandMMandtheresearchresultsontheoriginoflymphocyteandplasmacelbyanalyzingthemor-phologiccharacteristics,monoclonalantibodies,immunoglobulinIgorTCRgenerearrangement(GR),Igsinglestrandconformationpolymorphsm(SSCP)fingerprintmappingandheteroduplexformation.TheIgHGRsegmentssameinsize,singlestrandconformationandsequencecharacteristicshavebeenobtainedfrombothperipheralbloodandbonemarowDNA,eventhoughthecelsofCLLandMMhaddiferentcharacteristicsinmorphologyanddiferentsecretionofIgMλandIgAλ.TheresultssuggestedthatthemalignantcelsofbothCLLandMMinthispatienthadcommomoriginfromtheB-cel....

Concomitantchroniclymphocyticleukemia(CLL)andmultiplemyeloma(MM)isararedisease.Studiesontheclonaloriginofbothlymphocyteandplasmacelinthisdiseasehasbeenfew.SofarithasnotbeenreportedinChina.Thepaperreportsacaseof92-yearoldpatientwithconcomitantCLLandMMandtheresearchresultsontheoriginoflymphocyteandplasmacelbyanalyzingthemor-phologiccharacteristics,monoclonalantibodies,immunoglobulinIgorTCRgenerearrangement(GR),Igsinglestrandconformationpolymorphsm(SSCP)fingerprintmappingandheteroduplexformation.TheIgHGRsegmentssameinsize,singlestrandconformationandsequencecharacteristicshavebeenobtainedfrombothperipheralbloodandbonemarowDNA,eventhoughthecelsofCLLandMMhaddiferentcharacteristicsinmorphologyanddiferentsecretionofIgMλandIgAλ.TheresultssuggestedthatthemalignantcelsofbothCLLandMMinthispatienthadcommomoriginfromtheB-cel.

为进一步研究,慢性淋巴细胞白血病(CLL)伴多发性骨髓瘤(MM)细胞的克隆来源。报告1例高龄CLL合并MM的病例,结合临床形态学特征,用单克隆抗体,免疫球蛋白(Ig)基因和T-细胞受体(TCR)γ做标志,分析其恶性细胞的克隆来源。经过骨髓和外周血IgH重排基因的单链构象多态性(SSCP)指纹图谱以及异源双链形成法(HDF)分析发现,尽管CLL细胞和MM细胞的形态学特征不同,分泌IgM和IgA两种不同的免疫球蛋白,但是外周血和骨髓都能够用聚合酶链反应获得同样长度的Ig重链基因的V-D-J基因重排片段,都没有TCRγ基因的重排。SSCP指纹图谱和HDF法分析Ig基因序列特征显示CLL和MM细胞的V-D-J重排片段序列是一致的。说明其CLL和MM来源于同一个B-淋巴系统的祖细胞。

Endothelial cells play important physiological roles, the identity and abundance of mRNA species within endothelial cells indicate their biological potential. The induction of immediate early responses genes (ERG) in endothelials is critical to determining the ultimate outcome of exposure to mitogen. The response of endothelial cells to PMA, was explored with a complementary DNA microarray representing about 4 096 different human genes. Interestingly, most of the known genes (13/17) upregulated by PMA are...

Endothelial cells play important physiological roles, the identity and abundance of mRNA species within endothelial cells indicate their biological potential. The induction of immediate early responses genes (ERG) in endothelials is critical to determining the ultimate outcome of exposure to mitogen. The response of endothelial cells to PMA, was explored with a complementary DNA microarray representing about 4 096 different human genes. Interestingly, most of the known genes (13/17) upregulated by PMA are involved in signal transduction or kinases. 23 new genes are also upregulated and belong to ERG functionally. The sequence character, chromosome location and structure of one of the upregulated new genes are rsported, providing compelling experimnetal evidence to further research of this gene's function.

血管内皮细胞具有一系列重要生理功能 ,内皮细胞受外界刺激时可转录众多的mRNA ,体现了它们的生物学重要性 .内皮细胞的极早期应答基因 (Immediateearlyresponsegene ,ERG)是一类重要的介导基因 ,决定了外界刺激条件下细胞的最后反应模式 .以包含 40 96条各种人体基因的DNA芯片观察了血管内皮细胞受分化诱导剂PMA(phorbolmyristateacetate)激活后早期应答基因的表达谱 ,证实 17条ERG属已知基因 .数据处理聚类结果表明 ,多数ERG属蛋白质激酶及转录调控因子 ,2 3条上调新基因从功能上归类为ERG ;并且报道了其中的一条新基因的序列特征及其染色体位置和基因结构 ,为研究这个基因的功能提供了有力的实验依据 .

 
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