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卵巢癌coc
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  coc
     Construction and expression of a single-chain bispecific antibody COC183B2/anti-CD3 against human ovarian carcinoma
     抗人卵巢癌COC183B2/抗CD3单链双特异抗体的构建和表达
短句来源
     The Effects of the TRAIL Protein in Growth and Apoptosis of Ovarian Cancinoma COC1 Cell Line and the DDP-resistant COC1/DDP Cell Line
     TRAIL蛋白对卵巢癌COC1和COC1/DDP细胞生长及促凋亡作用研究
短句来源
     Results: The construction of a single-chain bispecific antibody COC183B2/anti-CD3 was successful.
     结果 :成功构建抗人卵巢癌COC183B2 /抗CD3scBsAb ;
短句来源
     Methods:The growth inhibitory effect of ultrasound exposure[0.8MHz,83.6W/cm 2,pulse duration(PD) 50μs;sonication time of 10s] on COC1 cell was observed by MTT colormetric assay.
     方法 :以低频脉冲聚焦超声 (超声频率 0 .8MHz ,声强 83.6W /cm2 ,脉肿持续时间 :5 0 μs)辐照卵巢癌COC1细胞 10s ,然后采用MTT法观察超声对COC1细胞增殖的抑制作用 ;
短句来源
     Objective: To investigate the effects of TRAIL protein in the growth and apoptosis of ovarian carcinoma COC1/DDP and COC1 cell lines.
     目的:为研究TRAIL对卵巢癌COC1和耐药COC1/DDP细胞生长及凋亡的影响。
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     Molecular Mechanism of Apoptosis in Cisplatin-resistant Human Ovarian Cancer Cell Line Promoted by Topotecan
     拓扑替康诱导卵巢癌COC1/DDP细胞凋亡的分子机制初步探讨
短句来源
     Methods: Human ovarian cell line COCl were exposed to PFU[ a frequency of 0.8MHz, with an intensity level of 83.6W/cm2 Pulse Average intensity, Pulse duration(PD) 20us-100us]during various exposure times and immediately tested for cell viability by MTT colormetric assay.
     方法:应用频率为0.8MHz,脉冲平均声强为83.6W/cm~2的PFU,以不同脉宽、不同持续时间照射离体人卵巢癌COC1细胞,应用MTT法观察超声对人卵巢癌COC1细胞的即刻杀伤作用;
短句来源
     Conclusions: (1) The overexpression of GSTπ and MRP2 may play an important role in the induction of resistance of COCl/DDP cells to cisplatin.
     结论:(1)GSTπ和MRP2基因高表达与卵巢癌COC1细胞获得顺铂耐药性有密切关系。
短句来源
     Methods: The growth inhibitory effect of Ultrasound Exposure ? 眼0.8 MHz, 83.6 W/cm2, Pulse duration (PD) 50 μs; sonication time of 10 s?
     方法:以低频脉冲聚焦超声(超声频率0.8MHz,声强83.6W/cm2,脉冲持续时间50μs)辐照卵巢癌COC1细胞10秒,采用MTT法观察超声对COC1细胞增殖的抑制作用;
短句来源
     Apoptosis Induced by Cisplatin in Human Ovarian Carcinoma Cell Lines
     顺铂诱导人卵巢癌COC_1、COC_1/DDP细胞凋亡的研究
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  相似匹配句对
     Patterns of Cisplatin Induced Apoptosis in Ovarian Cancer Cell Line COC 1
     顺铂诱导卵巢癌COC1细胞凋亡的观察
短句来源
     Immunotherapy for ovarian cancer
     卵巢癌的免疫治疗
短句来源
     Influence of Low Frequency Ultrasound on Proliferation and Apoptosis of Human Ovarian COC1
     低频超声对卵巢癌COC1细胞增殖和凋亡的影响
短句来源
     p27 and Ovarian Cancer
     p27与卵巢癌
短句来源
     CoC,should be resolved.
     质量合格(CoC)问题。
短句来源
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  coc
There were 563 cases in the CTGA group, 165 in the KHA group, and 217 cases in the conventional open craniotomy (COC) group.
      
Twelve homologous series of general formula H(CH2)SR are treated, where R denotes radicals such as -H, -OH, -C2H3, -COOH, -C6H5, -COCH3, -COC2H5, -COC3H7, -COC4H9, -COC5H11, -COC6H13, -COC7H15.
      
The Sr2+ and Ba2+ complexes have similar composition and structure: The oxygen atoms of two OH groups and six COC groups of a PEG molecule fill the first coordination sphere of the metal ions.
      
The latter reaction is proposed to involve reduction of the COC group with phenylhydrazine.
      
Cross-flow ultrafiltration techniques havc been used to separate colloidal organic carbon (COC) from natural water, and COC in three water samples that were collected from Huanghe, Changjiang and Qiantang River was determined.
      
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To explore a new method for adoptive cell immunotherapy of tumor and to develope a new tumor vaccine,tumor soluble antigen(TSA) was extracted from ovarian carcinoma cells.Peripheral blood mononuclear cells were induced by TSA and staphylococcus superantigen to develop tumor killing immune effect cells.Biological characters of the cells were studied in comparison of TAK,CD 3 AK,LAK,the results showed that the effect cells,TAK,CD 3 AK and LAK proliferated to 40.2 folds,41.7 folds,32.4 folds,21.5 folds in...

To explore a new method for adoptive cell immunotherapy of tumor and to develope a new tumor vaccine,tumor soluble antigen(TSA) was extracted from ovarian carcinoma cells.Peripheral blood mononuclear cells were induced by TSA and staphylococcus superantigen to develop tumor killing immune effect cells.Biological characters of the cells were studied in comparison of TAK,CD 3 AK,LAK,the results showed that the effect cells,TAK,CD 3 AK and LAK proliferated to 40.2 folds,41.7 folds,32.4 folds,21.5 folds in number respectively;cytotoxicity of the cells,TAK,CD 3 AK and LAK against ovarian carcinoma cells were 81.2% ,82.5%,54.3%,56.7% respectively,cytotoxicity of the cells against ovarian carcinoma cells COC1,COC2,SKOV3 and A2780,were 83.1%,51.4%,37.6% and 49.7% respectively.The results suggest that the cells proliferate more rapidly,have higher cytotoxicity against tumor cells compared with TAK,CD 3 AK and LAK,and have selective cytotoxicity against the tumor cells which the TSA come from.The study may provide a new idea for the adoptive cell immunotherapy and development of tumor vaccine.

为了探讨肿瘤过继细胞免疫治疗和研制肿瘤疫苗的新方法,用卵巢癌细胞(COC1)提取可溶性抗原成份,将其与葡萄球菌超抗原共同诱导外周血单个核细胞,置于含IL2的培养基中培养,待产生杀瘤性免疫效应细胞后,对这种细胞的某些生物学特性进行初步研究,并与TAK,CD3AK,LAK细胞进行比较。结果显示培养到第10d时,实验组效应细胞,TAK细胞,CD3AK细胞和LAK细胞的增殖活性分别为40.2倍,41.7倍,32.4倍和21.5倍;对卵巢癌COC1细胞的细胞毒活性分别为81.2%,82.5%,54.3%和56.7%。实验组效应细胞对4种卵巢癌细胞COC1,COC2,SKOV3和A2780的细胞毒活性分别为83.1%,51.4%,37.6%和49.7%。结果表明,用TSA和超抗原共同诱导产生的免疫效应细胞增殖快,细胞毒活性高,对来源于抗原的肿瘤细胞具有选择性杀伤作用。该实验方法和结果为肿瘤过继细胞免疫治疗和研制肿瘤疫苗提供了新思路

Objective: To generate a single-chain bispecific antibody (scBsAb) that could retarget human cytotoxic T lymphocytes to destroy human ovarian carcinoma cells. Methods: First, the heavy chain and light chain of anti-CD3 ScFv, and recombined anti-CD3 ScFv were cloned. Then the scBsAb was constructed by genetic engineering: The ScFvs of anti-human ovarian carcinoma COC183B2 and anti-CD3 were linked by an interlinker. The scBsAb was cloned in the expression vector pTMFC, with the comparison of COC183B2 or anti-CD3...

Objective: To generate a single-chain bispecific antibody (scBsAb) that could retarget human cytotoxic T lymphocytes to destroy human ovarian carcinoma cells. Methods: First, the heavy chain and light chain of anti-CD3 ScFv, and recombined anti-CD3 ScFv were cloned. Then the scBsAb was constructed by genetic engineering: The ScFvs of anti-human ovarian carcinoma COC183B2 and anti-CD3 were linked by an interlinker. The scBsAb was cloned in the expression vector pTMFC, with the comparison of COC183B2 or anti-CD3 ScFv. Finally, the activity of the scBsAb was detected by ELISA, flow cytometry and resetting assay. Results: The construction of a single-chain bispecific antibody COC183B2/anti-CD3 was successful. And the molecular weight of the scBsAb protein was about 60. The results showed that protein was capable of binding to antigen OC183B2 as detected by ELISA, to human CD3 by flow cytometry, and it had the ability to redirect the affected cells to the target tumor cells in vitro. Conclusion: A single-chain bispecific antibody COC183B2/anti-CD3 is constructed and expressed successfully, which can keep approximately the antigen-binding affinity of the two parent ScFvs.

目的 :构建和表达一种可与卵巢癌细胞和淋巴细胞结合的双特异抗体。方法 :利用PCR分别扩增抗人CD3单链抗体 (singlechainvariablefragment,ScFv)重链可变区 (variableregionoftheheavychain ,VH)和轻链可变区 (variableregionofthelightchain ,VL) ,重组抗人CD3ScFv ,经测序后将其克隆入有链间连接肽基因序列的载体pALM中 ,再将抗人卵巢癌COC183B2ScFv克隆至紧邻链间连接肽前形成COC183B2 /抗CD3单链双特异抗体(single-chainbispecificantibody ,scBsAb)的重组。最后将COC183B2 /抗CD3scBsAb克隆入表达载体 pTMFC中进行表达 ,同时分别表达抗人卵巢癌单抗COC183B2和抗人CD3单抗的ScFv作为对照组。用ELISA、流式细胞学方法和玫瑰花环实验对scBsAb进行免疫学活性测定。结果 :成功构建抗人卵巢癌COC183B2 /抗CD3scBsAb ;其表达的蛋白链相对分子质量约 6 0 ;ELISA结果显示sc...

目的 :构建和表达一种可与卵巢癌细胞和淋巴细胞结合的双特异抗体。方法 :利用PCR分别扩增抗人CD3单链抗体 (singlechainvariablefragment,ScFv)重链可变区 (variableregionoftheheavychain ,VH)和轻链可变区 (variableregionofthelightchain ,VL) ,重组抗人CD3ScFv ,经测序后将其克隆入有链间连接肽基因序列的载体pALM中 ,再将抗人卵巢癌COC183B2ScFv克隆至紧邻链间连接肽前形成COC183B2 /抗CD3单链双特异抗体(single-chainbispecificantibody ,scBsAb)的重组。最后将COC183B2 /抗CD3scBsAb克隆入表达载体 pTMFC中进行表达 ,同时分别表达抗人卵巢癌单抗COC183B2和抗人CD3单抗的ScFv作为对照组。用ELISA、流式细胞学方法和玫瑰花环实验对scBsAb进行免疫学活性测定。结果 :成功构建抗人卵巢癌COC183B2 /抗CD3scBsAb ;其表达的蛋白链相对分子质量约 6 0 ;ELISA结果显示scBsAb可与抗原OC183B2结合 ,流式细胞学结果显示scBsAb可与抗原CD3结合 ,花环实验显示scBsAb在体外可引导效应细胞聚集在靶细胞周围。结论 :构建和表达抗人卵巢癌COC183B2 /抗CD3scBsAb成功 ,且具有与抗原OC183B2、CD3结合的免疫学活性

Objective To observe the effect of mifepristone in enhancing chemosensitivity of drug-resistant ovarian cancer cell line to cisplatin and investigate its mechanism. Methods Human ovarian cancer cell lines COC1 (DDP-sensitive) and COC1/DDP (DDP-resistant) were incubated with or without mifepristone. The proliferation rate of the cells was determined by methyl thiazolyl tetrazolium (MTT) assay and positive expression of apoptosis-associated proteins Bcl-2 and Bax were ob-served by means of flow cytometry. Results...

Objective To observe the effect of mifepristone in enhancing chemosensitivity of drug-resistant ovarian cancer cell line to cisplatin and investigate its mechanism. Methods Human ovarian cancer cell lines COC1 (DDP-sensitive) and COC1/DDP (DDP-resistant) were incubated with or without mifepristone. The proliferation rate of the cells was determined by methyl thiazolyl tetrazolium (MTT) assay and positive expression of apoptosis-associated proteins Bcl-2 and Bax were ob-served by means of flow cytometry. Results It was observed that mifepristone at the dose of 1.25 μmol/L reversed the resis-tance of COC1/DDP cells to cisplatin, and Bcl-2 protein expression was deceased from (23.8067±0.4382)% to (19.3967±0.6866)% (P=0.000) while Bax protein expression increased from (12.75±0.2524)% to (25.5967±0.8834)% (P=0.000). Conclusion Mifepristone may act to enhance the sensitivity of COC1/DDP cells to cisplatin, possibly through regulating Bcl-2 and Bax protein expressions.

目的研究米非司酮对卵巢癌耐药细胞系COC1/DDP的增敏作用及其作用机制。方法用卵巢癌耐药细胞系COC1/DDP和敏感细胞系COC1为实验对象,四甲基偶氮唑蓝(MTT)法检测米非司酮对COC1/DDP细胞的增敏作用,流式细胞仪检测米非司酮对凋亡蛋白Bcl-2、Bax表达的影响。结果1.25μmol/L的米非司酮能够增强COC1/DDP对顺铂的敏感性,并使Bcl-2的阳性率从(23.80±0.44)%下降至(19.40±0.69)%(P=0.000),Bax从(12.75±0.25)%上升至(25.60±0.88)%(P=0.000),其逆转作用有剂量依赖性。结论米非司酮逆转卵巢癌COC1/DDP细胞对顺铂的耐药可能与下调Bcl-2的表达、上调Bax的表达、降低Bcl-2/Bax的比率有关。

 
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