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型糖尿病微血管并发症
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  type 2 diabetic microangiopathy
     A study for RAGE Gly82Ser polymorphism in Chinese type 2 diabetic microangiopathy
     中国人2型糖尿病微血管并发症与AGE受体基因Gly82Ser多态性相关研究
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  “2型糖尿病微血管并发症”译为未确定词的双语例句
     Expression and Clinical Significance of Platelet Membrane Protein CD62P and CD63P on Type II Diabetes Mellitus Combined with Micro-vascular Lesion
     血小板膜糖蛋白CD62P CD63在2型糖尿病微血管并发症患者的表达及临床意义
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     ⑥ The serum collagen Ⅳ had significant positive correlation with laminin (r=0.58, P < 0.001=. CONCLUSION: The levels of serum collagen Ⅳ and laminin are closely related to the occurrence and development of microvessel complication in type 2 diabetes and change of glucose.
     ⑥血清Ⅳ型胶原和层粘连蛋白水平呈显著正相关(r=0.58,P<0.001)。 结论:血清Ⅳ型胶原和层粘连蛋白水平与2型糖尿病微血管并发症的发生、发展及血糖的变化密切相关。
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     Study on the Relationship between Polymorphism of Manganese Superoide Dismutase Gene and Diabetic Microvascular Complications in Type 2 Diabetes Mellitus
     锰超氧化物歧化酶基因多态性与2型糖尿病微血管并发症相关性研究
短句来源
     Study on the Association between Diabetic Microangiopathy and Polymorphisms of the Aldose Reductase Gene in Type 2 Diabetes Mellitus
     醛糖还原酶基因多态性与2型糖尿病微血管并发症关系的研究
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     Objective To evaluate the role of BglⅡ restriction fragment length polymorphism within intron 7 of the α sununit of platelet α 2β 1 integrin in Chinese type 2 diabetes mellitus(DM) with diabetic microangiopathy(DMAP).
     目的 探讨血小板粘合素α2 β1分子α亚单位第 7内含子BglⅡ限制性片段多态性与2型糖尿病微血管并发症 (DMAP)的关系。
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     Relationship between cutaneous microcirculation and microvascular complications in type 2 diabetes mellitus
     2糖尿病皮肤微循环改变与其微血管并发症的关系
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     An epidemic factor research on the complication of type 2 diabetes mellitus
     2糖尿病并发症的病例对照研究
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     Relationship between plasma homocysteine and microangiopathy in type 2 diabetes mellitus
     血浆同半胱氨酸浓度与2糖尿病微血管并发症关系探讨
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     Conclusions Adiponectin and resistin take part in the development of insulin resistance,which may be orrelated with type 2 diabetes mellitus.
     抵抗素; 2糖尿病
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     Relationship between changes of the levels of sex horm ones and microvascular complications in postenopausal wom en with type-2 diabetes m ellitus
     绝经后2糖尿病性激素变化与微血管并发症关系
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Objective To investigate the association between dinucleotide repeat polymorphism at 5' end of aldose reductase (AR) gene and diabetic microangiopathy in Chinese. Methods A case control study for 362 Chinese subjects (including 217 type 2 diabetes mellitus with or without nephropathy or retinopathy and 145 non diabetes control) was performed. The number of (AC) n dinucleotide of AR gene was determined by PCR denaturing polyacrylamide gel electrophoresis. Results Tandem (AC) repeats of the AR gene were...

Objective To investigate the association between dinucleotide repeat polymorphism at 5' end of aldose reductase (AR) gene and diabetic microangiopathy in Chinese. Methods A case control study for 362 Chinese subjects (including 217 type 2 diabetes mellitus with or without nephropathy or retinopathy and 145 non diabetes control) was performed. The number of (AC) n dinucleotide of AR gene was determined by PCR denaturing polyacrylamide gel electrophoresis. Results Tandem (AC) repeats of the AR gene were highly polymorphic and 7 alleles were observed in type 2 diabetes mellitus and control. The most prevalent allele was 24 times in (AC) repeat and was designated as Z allele. In type 2 diabetes mellitus with both nephropathy and retinopathy, a decreased frequency of Z+6 allele was found in comparison with type 2 diabetes mellitus without microangiopathy (Fisher's exact, P=0.038). In addition, an elevated frequency of Z-2 allele was observed in type 2 diabetes mellitus with severe nephropathy (renal insufficiency) as compared with type 2 diabetes mellitus without nephropathy (Fisher's exact, P=0.039). Conclusion AR gene alleles are associated with the development of diabetic microangiopathy. The Z-2 allele of the AR gene may be a risk factor for developing severe nephropathy in type 2 diabetes mellitus.Whereas,the Z+6 allele may protect against the development and progression of diabetic nephropathy and retinopathy in Chinese subjects.

目的 探讨醛糖还原酶(AR)基因多态标记(AC)n 与中国人2 型糖尿病微血管并发症之间的关系。方法 用32P引物末端标记法,经聚合酶链反应变性聚丙烯酰胺凝胶电泳,检测362 例中国人(217 人为2 型糖尿病,其中156 人合并肾病或视网膜病变,145 人为非糖尿病对照)AR 基因的二核苷酸(AC)n 串联重复序列多态标记,比较各组间的等位基因频率和基因型频率。结果 (1)在非糖尿病对照者和2 型糖尿病患者中,见到七种AR 基因的等位基因,其中以(AC)24(138bp) 等位基因(Z)最常见。(2)同时合并肾病和视网膜病变的2 型糖尿病组与无并发症的2 型糖尿病组相比,Z+ 6等位基因频率显著减少(Fisher 确切, P=0 .038), 含Z+ 6 等位基因的基因型频率也显著减少(P=0.004)。(3) 无并发症的2 型糖尿病组与对照组比较其Z+ 6 等位基因频率显著增加( P= 0.044) 。(4)2 型糖尿病合并肾病伴肾功能不全者与不伴有肾病的2 型糖尿病者相比,Z- 2 等位基因频率显著增加( P= 0 .039),同时含Z- 2 等位基因的基因型频率也呈增加趋势。结论 AR...

目的 探讨醛糖还原酶(AR)基因多态标记(AC)n 与中国人2 型糖尿病微血管并发症之间的关系。方法 用32P引物末端标记法,经聚合酶链反应变性聚丙烯酰胺凝胶电泳,检测362 例中国人(217 人为2 型糖尿病,其中156 人合并肾病或视网膜病变,145 人为非糖尿病对照)AR 基因的二核苷酸(AC)n 串联重复序列多态标记,比较各组间的等位基因频率和基因型频率。结果 (1)在非糖尿病对照者和2 型糖尿病患者中,见到七种AR 基因的等位基因,其中以(AC)24(138bp) 等位基因(Z)最常见。(2)同时合并肾病和视网膜病变的2 型糖尿病组与无并发症的2 型糖尿病组相比,Z+ 6等位基因频率显著减少(Fisher 确切, P=0 .038), 含Z+ 6 等位基因的基因型频率也显著减少(P=0.004)。(3) 无并发症的2 型糖尿病组与对照组比较其Z+ 6 等位基因频率显著增加( P= 0.044) 。(4)2 型糖尿病合并肾病伴肾功能不全者与不伴有肾病的2 型糖尿病者相比,Z- 2 等位基因频率显著增加( P= 0 .039),同时含Z- 2 等位基因的基因型频率也呈增加趋势。结论 AR 的Z- 2 等位基因是促进中国人2 型糖尿病并发严

Objective To investigate the association between a new identified Gly82Ser polymorphism of RAGE gene and diabetic microangiopathy,a case control study of 260 Chinese subjects (including 156 type 2 diabetics with or without nephropathy or retinopathy and 104 non diabetic control) was performed.Methods Genotype frequencies of Gly82Ser polymorphism were studied by PCR RFLP analysis with AluI digestion.Results The most frequent genotype and allele of Gly82Ser polymorphism of RAGE gene in Chinese were genotype...

Objective To investigate the association between a new identified Gly82Ser polymorphism of RAGE gene and diabetic microangiopathy,a case control study of 260 Chinese subjects (including 156 type 2 diabetics with or without nephropathy or retinopathy and 104 non diabetic control) was performed.Methods Genotype frequencies of Gly82Ser polymorphism were studied by PCR RFLP analysis with AluI digestion.Results The most frequent genotype and allele of Gly82Ser polymorphism of RAGE gene in Chinese were genotype GG and allele G.Their frequency distribution showed significant difference between Chinese and Caucasian.There was no difference in genotype frequencies or allele frequencies between type 2 diabetic patients (DN 0) and the control subjects.Genotype and allele frequencies did not differ in type 2 diabetic subjects with nephropathy or without nephropathy.Moreover,there were no associations between diabetic patients with or without retinopathy in genotype and allele frequencies as well (two tailed Fisher's exact P >0.05).Conclusion Our results showed that Gly82Ser polymorphism in RAGE gene was not associated with diabetic microangiopathy,which suggests that these genetic variants may not be involved in the mechanism of diabetic microangiopathy in Chinese type 2 diabetics.

目的 探讨 AGE受体 (RAGE)基因 Gly82 Ser多态性与中国人 2型糖尿病微血管并发症间的关系。方法 使用限制性内切酶 Alu I(AG↑ CT)的 PCR- RFL P法 ,检测 10 4例非糖尿病对照者和 15 6例 2型糖尿病伴或不伴肾病、视网膜病变者的 RAGE基因 Gly82 Ser的多态基因型。结果 中国人 RAGE基因 Gly82 Ser多态基因型以 GG型、等位基因以 G型为最多见 ,但频率分布与白种人相比有显著性差异。非 DM对照组与 2型糖尿病伴或不伴有肾病的 4个亚组间、与伴或不伴有视网膜病变的 2个亚组间 ,RAGE基因的 Gly82 Ser多态的基因型 (GG、GS、SS)频率或等位基因 (G、S)频率皆无显著性差异 (Fisher's确切 P值 >0 .0 5 )。结论  RAGE基因的 Gly82 Ser多态引起的 RAGE功能性氨基酸突变与 2型糖尿病微血管并发症的发生及进展无显著性相关

Objective To find TCM methods to treat the microangiopathy complications of diabetes. Method\ Based on the decoction of Wen Dan Tang. Some revistions were made in the prescription (Reducing radix glycyrrhizae, Rhizoma zingiberis recens, Fructus ziziphi jujubae. With the Fructus Aurantii to replace the Fructus Aurantii Immaturus) to treat different microangiopathy complications of diabetes. Result\ The decoction of Wen Dang Tang was used and some revisions were made in the recipe following the various symptom...

Objective To find TCM methods to treat the microangiopathy complications of diabetes. Method\ Based on the decoction of Wen Dan Tang. Some revistions were made in the prescription (Reducing radix glycyrrhizae, Rhizoma zingiberis recens, Fructus ziziphi jujubae. With the Fructus Aurantii to replace the Fructus Aurantii Immaturus) to treat different microangiopathy complications of diabetes. Result\ The decoction of Wen Dang Tang was used and some revisions were made in the recipe following the various symptom complexes to treat more than a hundred patients with different kinds of microangiopathy complications of diabetes like the stagnation of phlegm and the stasis of vital energy (such as: retinal disease, nephropathy, acromelic gangrene). Satisfactory curative effects were obtained. Conclusion\ In clinical practice, as soon as a doctor finds any patient with diabetes who has suffered from the symptoms caused by stagnancy of vital energy and stasis of phlegm, it is advisable to apply the changed Wen Dan Tang which is according to the Bian Zheng Luen Zhi (diagnosis and treatment based on an overall analysis of symptoms and signs, including the cause, nature and location of the illness and the patient's physical condition according to the TCM basic theory).

目的 寻找中医治疗糖尿病微血管并发症的方法。方法 以温胆汤去炙甘草、生姜、大枣 ,以枳壳代枳实 ,作为基本方 ,随证加减用于糖尿病微血管并发症的治疗。结果 治疗痰郁气型糖尿病微血管并发症 (如 :视网膜病变、肾病、肢端坏疽 ) 10 0多例 ,取得良好疗效。结论 只要见到痰郁气滞的症候 ,即可辨证施用温胆汤治疗。

 
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