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i类基因
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     Detection of MAGE-A3Antigen and HLA-class I Gene Distribution in Lung Cancer
     肺癌患者MAGE-A3抗原表达及HLA-I类基因分布的初步研究
短句来源
     Detection of MAGE-A3 Antigen and HLA-class I Gene Distribution in Lung Cancer
     肺癌患者MAGE-A3抗原表达及HLA-I类基因分布的初步研究
短句来源
     Objective In order to predict the ratio of lung cancer patients who ca n be treated with immunotherapy based on MAGE-A3 antigen, the expression of MAG E-A3 antigen and the distribution of HLA-class I gene were investigated in lung c ancer tissues.
     目的 检测MAGE- A3抗原在肺癌组织中的表达情况以及HLA- I类基因在肺癌患者中的分布水平 ,以预测能够应用以MAGE- A3抗原蛋白为基础的肿瘤疫苗进行肿瘤免疫治疗的肺癌患者的比例。
短句来源
     Result showed that twenty one strains contained three cry type genes: cry1, cry2 and cry 1I, six strains contained both cry 1 and cry 2 genes, four strains contained both cry 1 and cry 1I type genes, one strain contained cry 1 type gene, four strains contained cry 2 type gene. 36 strains did not contain ten cry type genes.
     研究表明 :同时含有cry1,cry2 ,cry1I 3类基因的有 2 1株菌 ,6株菌含有cry1,cry2类基因 ,4株菌含有cry1和cry1I类基因 ,只含有cry1基因的有 1株 ,cry2类基因的 4株 ,36株菌不含所鉴定的 10类cry基因。
短句来源
     Association of Gene HLA-class I with Leukemia
     HLA-I类基因与白血病相关性研究
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  相似匹配句对
     C.
     C
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     4 new genes were obtained.
     U基因
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     Studies on the Major Histocompatibility Complex Class Ⅱ of Giant Panda (Ailuropoda Melanoleuca)
     大熊猫主要组织相容性复合体Ⅱ基因研究
短句来源
     Association of Gene HLA-class I with Leukemia
     HLA-I基因与白血病相关性研究
短句来源
     MOLECULAR CLONING OF CLASS I GENES IN THE MAJOR HISTOCOMPATIBILITY COMPLEX OF RAT
     大鼠MHC-Ⅰ基因cDNA的克隆
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  class i gene
The cataract Shionogi mouse, a sister strain of the non-obese diabetic mouse: similar class II but different class I gene produc
      
Soluble donor MHC class I gene transfer to thymus promotes allograft survival in a high-responder heart transplant model
      
The antibody reacts also with L cells expressing a cloned H-2b class I gene mapping in the Qa-Tla region.
      
Occurrence of a unique MHC class I gene in distantly related members of the genus Mus
      
There is unequivocal evidence that a relatively nonpolymorphic class I gene (designated Q10) from the Qa region of inbred mice encodes a secreted class 1 molecule.
      
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Objective: To strengthen the immunogenicity of hepatocarcinoma cells and activate immnological cells recognizing and killing the tumor cells.Methods:The murine MHC-I gene H-2Kb which can express immunologial rejection antigens was transfected into human hepatocarcinoma cells HepG2 by liposome DNA mediated gene gene transfer.The transfection of H-2Kb gene were detected by molecular hybridization techniues.The exogeous antigens expressed on the membrane of trans- fected tumor cells were detected with ABC immunohistochemical...

Objective: To strengthen the immunogenicity of hepatocarcinoma cells and activate immnological cells recognizing and killing the tumor cells.Methods:The murine MHC-I gene H-2Kb which can express immunologial rejection antigens was transfected into human hepatocarcinoma cells HepG2 by liposome DNA mediated gene gene transfer.The transfection of H-2Kb gene were detected by molecular hybridization techniues.The exogeous antigens expressed on the membrane of trans- fected tumor cells were detected with ABC immunohistochemical method and flow cytometer. [3H] release assays were used to detect the recognizing and killing effects of lymphocytes to HepG2 cells transferred with murine H-2Kb gene. The nude mice ex- periment was used to further verify CTL cells killing active.Results:Southern blot hybridization showed that the H-2Kb gene was integrated into the chromosome of HepG2 cells. The RNA dot blot hybridization showed that there was transcription of H-2Kb DNA in the transfected tumor cells.ABC immunohistochemical method and flow cytometer detection showed that the murine H-2Kb antigens were expressed on the membrane of HepG2 cells. [3H] release assays showed that the cytotoalcyty to HepG2 cells fected with H-2Kb gene was obviously higher than that to control cells.The results demonstrated that the growth of hepatocarcino- ma cells which were transferred with H-2Kb gene was obviously inhibited.Conclusion:The murine MHC-I gene H-2Kb could be transferred into the human hepatocinoma cells and expressed on the membrane of transferred cells.The HepG2 cells transferred with H-2Kb gene could induce human effective lymphocytes to recognize and kill these transferred tumor cells.

目的:增强人肝癌细胞的免疫原性以激活宿主免疫细胞识别杀伤相应的肝癌细胞。方法:以脂质体介导小鼠H-2Kb基因转染肝癌细胞株,并检测H-2Kb抗原表达情况,然后用H-2Kb基因转染后的肝癌细胞体外激活效应细胞杀伤活性,再进行裸鼠动物实验。结果:H-2Kb基因转染人肝癌细胞株HepG2后,Southem印迹杂交结果显示,H-2Kb基因整合于肿瘤细胞染色体中,RNA点杂交结果显示,H-2KbDNA已转录成mRNA。免疫组化及流式细胞仪检测显示,H-2Kb抗原已在肝癌细胞胞膜上表达。转染后肝癌细胞在体外能强烈诱发效应细胞毒性,这种细胞毒性现象在裸鼠实验中得到进一步验证。结论:异源MHG-I类基因H-2Kb转染肝癌细胞后可增强其免疫原性并激活免疫效应细胞杀伤活性。

Based on the method of PCR RFLP and SDS PAGE, cry genes and their expression products of 72 isolates of Bacillus thuringiensis from different forestry site zones in China were analyzed. Result showed that twenty one strains contained three cry type genes: cry1, cry2 and cry 1I, six strains contained both cry 1 and cry 2 genes, four strains contained both cry 1 and cry 1I type genes, one strain contained cry 1 type gene, four strains contained cry 2 type gene. 36 strains...

Based on the method of PCR RFLP and SDS PAGE, cry genes and their expression products of 72 isolates of Bacillus thuringiensis from different forestry site zones in China were analyzed. Result showed that twenty one strains contained three cry type genes: cry1, cry2 and cry 1I, six strains contained both cry 1 and cry 2 genes, four strains contained both cry 1 and cry 1I type genes, one strain contained cry 1 type gene, four strains contained cry 2 type gene. 36 strains did not contain ten cry type genes. Most cry 1 genes encoded 130 kDa protein toxic to Lepidopteran pest, and most cry2 genes encoded 60 kDa protein.The isolates containing cry 1Aa, cry 1Ac and cry 2 type genes were highly toxic to Helicoverpa armigera larvae, isolates containing one or no cry gene had low or no toxicity activity to pests.

利用苏云金芽孢杆菌cry基因的PCR RFLP鉴定体系和SDS PAGE方法分析了来自我国不同森林立地带土壤中的 72株苏云金芽孢杆菌的cry1、cry2、cry3、cry4、cry5、cry8、cry9、cry10、cry11、cry1I等 10类基因类型和表达蛋白 ,并进行了杀虫活性的生物测定。研究表明 :同时含有cry1,cry2 ,cry1I 3类基因的有 2 1株菌 ,6株菌含有cry1,cry2类基因 ,4株菌含有cry1和cry1I类基因 ,只含有cry1基因的有 1株 ,cry2类基因的 4株 ,36株菌不含所鉴定的 10类cry基因。同时证明 ,绝大多数含有cry1基因的菌株表达了 130kDa蛋白 ,含有cry2基因的菌株表达了 6 0kDa蛋白。生物活性测定表明 ,共同含有cry1Aa、cry1Ac和cry2基因的菌株对棉铃虫幼虫具有较强的杀虫活性 ,只含有单一基因和不含上述基因的菌株杀虫活性较弱。

Object:TO investigate the expression Of MAGE-A3 antigen and thedistribution Of HLA-class l gene in lung cancer tissues,and to predict the ratio Of lungcancer patients who can be treated with immunotherapy based on MAGE-A3 antigen.Methods:SDS-PAGE and Western blot analysis were used to detect the expression of MAGE-A3 antigen in 63 lung cancer patients(include tumor tissues and their adjacenttissues).PCR-SSP technique was used to detect the distribution of HLA-A1,A2 and A24 gene in 70 lung cancer patients and...

Object:TO investigate the expression Of MAGE-A3 antigen and thedistribution Of HLA-class l gene in lung cancer tissues,and to predict the ratio Of lungcancer patients who can be treated with immunotherapy based on MAGE-A3 antigen.Methods:SDS-PAGE and Western blot analysis were used to detect the expression of MAGE-A3 antigen in 63 lung cancer patients(include tumor tissues and their adjacenttissues).PCR-SSP technique was used to detect the distribution of HLA-A1,A2 and A24 gene in 70 lung cancer patients and their tumor adjacent.Results Of 63 lung cancer patients,31 tumor tissues(49.21%)have MAGE-A3 antigen expression,and 5 tumor adjacent tissues also had MAGE-A3 antigen expression.Of 70 lung cancerpatients the distribution Of HLA-A1,A2 and A24 are 4.28%,54.28%,and 50.0%respectively.Of 70 tumor adjacents the distribution Of HLA-A1,A2,A24 are 4.28%,60.0%,and 52.86%respectively.The total positive rate Of HLA-A1,A2,A24 is 80%in lung cancer tissues.Conclusion:There are.about39%lungcancerpatients(80.0%×49.21%)who can be treated with immunotherapy based on MAGE-A3 antigen.

目的 检测MAGE -A3抗原在肺癌组织中的表达情况以及HLA -I类基因在肺癌患者中的分布水平 ,以预测能够应用以MAGE -A3抗原蛋白为基础的肿瘤疫苗进行肿瘤免疫治疗的肺癌患者的比例。方法 用SDS -PAGE和Westernblot方法检测 6 3例肺癌及其癌旁组织MAGE -A3抗原的表达情况 ;用PCR -SSP方法检测 70例肺癌及癌旁组织HLA -A1、A2、A2 4的分布频率。结果  6 3例肺癌患者中有 31例为MAGE -A3抗原表达阳性 ,其中 5例癌旁组织MAGE -A3抗原也为阳性。 70例肺癌患者中HLA -A1、A2、A2 4三个等位基因的分布频率分别为 4 .2 8%、5 4 .2 8%、5 0 .0 % ;70例癌旁组织中HLA -A1、A2和A2 4的阳性率分别为 4 .2 8%、6 0 .0 %和 5 2 .86 %。三等位基因中任一基因在肺癌组织出现的频率为 80 %。结论 肺癌患者中大约有 39%的个体能应用基于MAGE -A3抗原蛋白的肿瘤疫苗进行有效的肿瘤免疫治疗。

 
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