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儿童all
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  childhood all
     CR rate of childhood ALL was 87.1%, while of elderly AML only 26%.
     儿童ALL的CR率最高 ,达87 1% ,老年人AML的CR率最低 ,仅为 2 6 %。
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     Comparing with expression of normal peripheral blood mononuclear cell, EST screened in D6S1709-D6S301(GenBank Accession No.AA403058) was down-regulation in ten of fifteen childhood ALL (P < 0.05).
     在D6S1709~D6S301之间筛选到一个在儿童ALL细胞中低表达的EST(GenBank登录号:AA403058),与正常外周血单个核细胞比较,在15例ALL患者中有10例表达下调(P<0.05).
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     Results Of the 45 untreated childhood ALL samples, 32 were positive for p73 gene mRNA expression by RT-PCR, 13 were negative of p73 gene mRNA with negative rate of 28.9%( 13/45), while of all 10 normal children were positive for p73 expression.
     结果 45例儿童ALL患者中,32例p73mRNA表达阳性,13例p73mRNA表达阴性,阴性表达率为28.9%(13/45),而正常对照p73mRNA皆有表达。
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     Conclusions Aberration antigen expression in childhood ALL is about 29.63 %.
     结论 儿童ALL的抗原错译表达率为2 9.63 % ;
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     Conclusion CIK cells/IL 2 immunotherapy can be used to eradicate MRD in childhood ALL.
     结论 CIK/IL 2治疗具有清除MRD、减少儿童ALL复发的作用
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  children all
     Results:The detecting rate of aneuploid in 84 cases of ALL was 38.1 % , of whom , 45.5 % in children ALL and 35.5 % in adult ALL .
     结果 :84例急性淋巴细胞白血病异倍体检出率为 38.1% ,其中儿童AL L4 5 .5 % ,成人 AL L35 .5 %。
短句来源
     These findings suggested that MDM2mRNA over expression plays animportant role in children ALL. Furthermore, MDM2mRNA over expression is associated with HALL
     认为 MDM2过度表达在儿童 AL L 发病中起有重要作用 ,并与儿童 AL L 的不良预后、高白细胞性有显著相关性
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     Conclusion These results suggested at present that immunophenotyps is important in judging the therapeutic effect and EFS of children ALL.
     结论目前儿童ALL的免疫表型测定在判断其疗效与预后方面有着重要作用
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     Methods: A case-control study consisting of 183 children ALL patients and 190 controls in a Chinese population was performed to examine the genotypic frequency of the cyclin D1 polymorphism.
     方法:采用聚合酶链反应(PCR)和PCR-RFLP方法,分析183例儿童ALL患者和190例健康对照者的CyclinD1基因型。
短句来源
     Conclusion: The cyclin D1 genetic polymorphism might be closely related to the occurrence of children ALL in the Chinese population.
     结论:Cy-clinD1基因多态性与中国儿童ALL的发生、发展及预后密切相关。
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  “儿童all”译为未确定词的双语例句
     Results Eighteen (33.96%) cases carried 11 types of fusion genes including SIL/TAL1D,E2A/PBX1,TEL/AML1,MLLex7/AF9,MLLex8/AF9,MLLex8/AF10,MLLex8/AFX,MLLex9/AF6, MLLex9/ELL, MLLex7/AF4 and TLS/ERG from the 53 samples.
     结果53例儿童ALL中18例(33·96%)具有11种克隆性基因重排,包括SIL/TAL1D、E2A/PBX1、TEL/AML1、MLLex7/AF9、MLLex8/AF9、MLLex8/AF10、MLLex8/AFX、MLLex9/AF6、MLLex9/ELL、MLLex7/AF4及TLS/ERG。
短句来源
     Results The allele frequencies of A11, A24, B40, B15, B56, B67, B27 were increased, while the allele frequencies of HLA-B48 were decreased in patients with ALL.
     结果在HLA-A,B等位基因中,儿童ALL患者的A11,A24,B40,B15,B56,B67,B27等基因的基因频率都显著高于正常人群,而HLA-B48基因的基因频率显著下降(P<0.05)。
短句来源
     Among eighty six cases of ALL, 95.3% was B-ALL, in which common-ALL and Pro-B-ALL were 76.8% and 6.1%, respectively, and 2.3% was T-ALL.
     86例儿童ALL标本中 ,B ALL占 95 .3% ,T ALL占 2 .3%。 Common ALL和Pro B ALL分别占B ALL的76 8%和 6 .1%。
短句来源
     Results The expression of nm-23H1 gene in ALL and AML of children was significantly higher than that in normal subjects. In AML,nm-23Hl′s level of the group M_4+M_5 was higher than that the group M_2+M_3(P<0.05).
     结果儿童ALL、AML中nm23H1基因表达显著高于正常对照组(P<0.001),AML中M4+M5组的nm23H1表达程度较M2+M3组高(P<0.05)。
短句来源
     Result: A-mong 103 ALL,of 67(65. 05%)were diagnosed as ALL-L1,out of 33(32. 04%)as ALL-L2, 3(4. 91%)as others.
     结果:103例儿童ALL患者中,67例(65.05%)为L_1型,33例(32.04%)为L_2型,无L_3型,3例(4.91%)为其他。
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  childhood all
Methods: The GCR level of venous blood lymphocytes was measured by receptor radioligand binding assay in 50 cases with childhood ALL and 41 normal children.
      
Gene expression arrays and comparative genomic hybridization have further extended our appreciation of the known immunophenotypic and genetic diversity of childhood ALL.
      
Future studies of neurobehavioral outcome are briefly elaborated in the context of current chemotherapy approaches used in the treatment of childhood ALL.
      
It was suggested that GSTM1 null genotype might be a risk genotype of childhood ALL.
      
While there as no correlation between GSTT1 null genotype and childhood ALL.
      
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  children all
Conclusion: The GCR level of the peripheral venous blood lymphocytes in children ALL may be an important biochemistry indicator and used to predict prognosis and guide combination chemotherapy.
      
These four children all had seizure activity and abnormal initial neurological examinations and required admission to the PICU.
      
We report clinical and neurophysiological findings in six children (three female, three male) with type I lissencephaly and three children (all female) with type II lissencephaly (Walker-Warburg syndrome).
      
By 1979, numerous authors had reported the safety of non-operative management in hundreds of children all over the world.
      
Intussusception is very common in children all over the world, especially those under 2 years.
      
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he clinical results of 57 children with ALL admitted to Xin Hua Hospital since January 1988 through Decem-ber 1991 were analyzed. The complete remission (CR )rate was 96. 5 % ( 55/57 ). The continuous complete re-mission (CCR) and survival rate at 5 year in 48 caseswho have been consecutively treated with XH-88 proto-col and followed sequentially were 81.3% and 85. 4%respectively. The CCR and survival rate at 5 year in 24children with HR-ALL were 75 % and 87. 5 %, while in24 witli SR-ALL were 79.1%and 91.7%...

he clinical results of 57 children with ALL admitted to Xin Hua Hospital since January 1988 through Decem-ber 1991 were analyzed. The complete remission (CR )rate was 96. 5 % ( 55/57 ). The continuous complete re-mission (CCR) and survival rate at 5 year in 48 caseswho have been consecutively treated with XH-88 proto-col and followed sequentially were 81.3% and 85. 4%respectively. The CCR and survival rate at 5 year in 24children with HR-ALL were 75 % and 87. 5 %, while in24 witli SR-ALL were 79.1%and 91.7% , respective-ly. These results showed that initial and continuous in-tensive clieniotherapy was the key point to get higherLTDFS.

1988~1991年收治的儿童急性淋巴细胞白血病(ALL)57例,55例获完全缓解(CR),CR率是96.5%,其中48例坚持XH-88方案治疗,其预期5年以上CCR率和生存率分别是81.3%和85.4%。标危型急淋(SR-ALL)和高危型急淋(HR-ALL)各24例,其预期5年以上CCR率和生存率分别是87.5%和75%、91.7%、79.1%。结果表明,早期连续强烈化疗对儿童ALL的长期无病生存(LTDFS)是至关重要的。

ell

本文就21例儿童ALL细胞表面标记进行了研究。结果表明,21例儿童ALL中普通ALL(Common-ALL)最多(8/21),预后较好。T-ALL也不少见(7/21),T-ALL中以I型多见,采用大剂量化疗后预后改善。Ⅱ、Ⅲ型T-ALL预后较差。

To investigate the correlation between the multiple tumor suppressor(TMS1)gene mutationand malignant hematologic disorders,the MTS1 gene alterations in 35 children with acute Leukemia(AL)were detected with the methods of PCR-SSCP and southern blot. It showed that the deletions on ALL(in-cluding the point mutations)were 25. 8% (8/31); homozygous deletions in B-cell and T-cell acute lym-phoblastic Leukemia(B-ALL and T-ALL)were 16% (4/25)and 33% (2/6)respectively .The point mu-tations were found only in one B-cell...

To investigate the correlation between the multiple tumor suppressor(TMS1)gene mutationand malignant hematologic disorders,the MTS1 gene alterations in 35 children with acute Leukemia(AL)were detected with the methods of PCR-SSCP and southern blot. It showed that the deletions on ALL(in-cluding the point mutations)were 25. 8% (8/31); homozygous deletions in B-cell and T-cell acute lym-phoblastic Leukemia(B-ALL and T-ALL)were 16% (4/25)and 33% (2/6)respectively .The point mu-tations were found only in one B-cell and one T-cell cases .This study suggested that in our country theMTS1 gene in activation could be found in ALL children and the incidence in T-All might exceed that ofB-All, but the point mutations were found in rare cases. Therefore, there was a close correlation betweenMTS1 gene inativation and development of AL and intimate involvement in clinical prognosis.

为探讨MTS1基因突变与恶性血液病的关系,应用PCR-SSCP和DNA印迹方法检测35例急性白血病(AL)患儿MTS1基因改变。结果显示:急性淋巴细胞白血病(ALL)缺失(包括点突变)为25.8%(8/31)。B-ALL纯合缺失为16%(4/25),T-ALL为33%(2/6)。点突变则两型各1例。结果证明:我国儿童ALL有MTS1基因失活的存在,T-ALL高于B-ALL,点突变仅见于少数病例。该基因失活与AL的发生发展及临床预后有密切关系。

 
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