One molecular mechanism of skin photoaging is that UVA and UVB induce MMPs gene transcription of epidermal keratinocytes and dermal fibroblasts through activating cellular signal transduction pathways.
AIM: To explore the effects of cellular signal transduction pathways of heme oxygenase-1(HO-1)-carbon monoxide (CO)-cyclic GMP (cGMP) and nitric oxide synthase (NOS)-nitric oxide (NO)-cGMP on cholecystokinin octapeptide (CCK-8) reversed vascular hyporeactivity in endotoxemic rats.
Results: The expression of 370 genes in the PTX-intervention group changed over twofold as compared with those in the model group, among which, 57 were up-regulated in the model group (vs. control group), but down-regulated after PTX-intervention (vs. model group), including related genes of inflammatory/immune response, cellular signal transduction, extracellular matrix and cell adhesion molecules, metabolic enzyme and biotransformation, ion channels/transporters, etc;
Objective:To investigate the expression of FAK (focal adhesion kinase) and PTEN (phosphatase and tensin homology deleted on chromosome ten) in the breast carcinoma tissue, to seek their relationship with tumor cell proliferation, invasion and metastasis, to study the relationship between the cell signaling transduction system mediated by FAK and the carcinognesis, development of breast carcinoma, and to provide the experimental basis of prognosis judgement for breast carcinoma.
目的:研究乳腺癌组织中粘着斑激酶(focal adhesion kinase,FAK)和PTEN(phosphatase and tensin homology deleted on chromosome ten)的表达与肿瘤细胞增殖、侵袭转移的关系,探讨FAK介导的细胞信号转导系统与乳腺癌发生发展的关系,同时为乳腺癌的预后判断提供实验依据。
AIM: To study the expression of apoptosis signal proteins induced by Fas in labial salivary gland of patients with primary Sjgren's syndrome(pSS),and investigate the possible pathway of the cell signaling transduction in pSS.
Objective To study the expression of related protein of apoptosis signaling transduction induced by Fas in labial salivary gland of patients with sjogren syndrome(pSS) , and to explore the possible pathway of cell signaling transduction resulting in pSS.
This review summarizes recent data on various groups of lysophospholipid receptors and their cell signal transduction pathways.
In this article, we review how pluripotent stem cell signal transduction mechanisms and transcription factor circuitries integrate information provided by the microenvironment.
CD19/Lyn complex formation also regulates phosphorylation of CD22 and FcγRIIB, which inhibit B cell signal transduction through the recruitment of the SHP1 and SHIP phosphatases.
Biological functions of these proteins are related to cell signal transduction, cell proliferation, cell motility, glycolysis, regulation of transcription, oxidative stress processes, and protein folding.
However, not all patients with severe defects in B-cell development have mutations in BTK or the components of the B-cell signal transduction complex.
Introduction to Cellular Signal Transduction (Ari Sitaramayya, ed., Birkhauser, Boston-Basel-Berlin, 1999, 311 p.)
Cadmium is a toxic transition heavy metal of continuing occupational and environmental concern, with a wide variety of adverse effects on regulation of gene expression and cellular signal transduction pathways.
Zinc homeostasis in mammalian cells is precisely regulated by cellular signal transduction mechanisms.
This article reviews how these KSHV proteins modulate cellular signal transduction pathways.
This new function confers a ligand-like effect to cardiotonic steroids on cellular signal transduction.