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|  | | 为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法,我们为您准备了出自英文原文的大量英语例句,供您参考。 | |
Surface markers on peripheral blood lymphocytes of patients with follicular lymphoma suggesting a clonal origin
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A clonal origin of aldosteronomas has also been suggested [28].
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The polymerase chain reaction (PCR) can be utilized to establish the clonal origin of B-or T-cell lymphocyte populations by amplification of rearranged immunoglobulin and T-cell receptor (TCR) genes.
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Ten of 20 TSHR or Gsα mutation negative cases (50%) showed nonrandom X-chromosome inactivation, indicating clonal origin.
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It appears that these well-characterized regimens of carcinogenesis yield T-cell tumors showing gene rearrangements consistent with a clonal origin of the tumors.
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| | onoclonality of B cell lymphoma at DNA level was detected by using the polymerase chain reaction (PCR). Of 40 clinical lymph node biopsy and aspiration specimens obtained from different kinds of diseases , the positive rates of detection were : 13/15 (87%) for B cell lymphoma , 0/3 for T cell lymphoma , 0/3 for Hodgkin's disease , 0/8 for reactive lym- phadenopathy and 0/11 for non-lymphoid tumor. The result above is consistent roughly with that from histology and immunohistochemistry examination. Our study... | | 应用聚合酶链反应(PCR)技术从DNA水平测定B细胞非霍奇金淋巴瘤的单克隆起源,以用于淋巴瘤的诊断。40例标本检测的阳性结果为;B细胞淋巴瘤13/15例,T细胞淋巴瘤0/3例,霍奇金病0/3例,慢性淋巴结炎0/8例,非淋巴源性肿瘤0/11。与组织学及免疫组化诊断符合率为87%。本研究在把分子生物学的新方法用于B细胞淋巴瘤的临床诊断方面作出初步的探索。关键词 | | 文摘来源 | | To clarify the cytogenetic characteristics, chromosome changes of 33 cases of squamous cell carcinomas of larynx from fresh operation samples were analyzed with direct chromosome preparation. Metaphases were obtained from 14 cases,and detailed G-banding analyses were completed from 8 cases. Three cases of them were diploid, five cases of them were triploid.The frequent characteristic changes of chromosome were as follows:6q-(three cases),i(8q)(two cases),+8(two cases),i(5p)(one case),3p-(four cases),DM, whi... | | 本研究应用G-显带对原发性喉鳞状细胞癌手术新鲜标本进行了直接法染色体分析。有8例能进行核型分析,其中3例在二倍体范围,5例在三倍体范围。结果提示:i(8q)及6q-可能是喉癌的特征性改变;3p-在喉癌的发生上起一定的作用。尤为重要的是:喉癌的发生倾向于单克隆起源。 | | 文摘来源 | | Objective To investigate the clonality of midline T cell lymphoma. Methods Using polymerase chain reaction method and a panel of family specific primers for the variable regions of TCR γgene, and totally 11 cases (22 samples) of midline T cell lymphoma (midline malignant reticulosis) were studied. Results Family specific monoclonal TCR γgene rearrangements were found in 21 out of 22 samples (94.45%). There was no change of clonality during the course of disease. Conclusion There is monoclonal T ce... | | 目的对中线T细胞淋巴瘤的克隆性进行研究。方法用一组针对T细胞受体γ链基因V区片段的家族特异性引物和PCR方法,对11例(22个标本)中线T细胞淋巴瘤病例进行了T细胞受体γ基因重排的检测。结果22个标本中21个有T细胞受体γ链基因的克隆性重排(9445%)。在9例原发灶的连续活检和1例原发灶及其转移灶的标本中均未发现增生的克隆家族的改变。结论中线T细胞淋巴瘤的病变组织中存在T细胞的单克隆性增生,为该肿瘤的T细胞起源提供了分子生物学的证据。在中线T细胞淋巴瘤的疾病过程中(包括转移灶)增生T细胞的家族未发生变化,支持肿瘤的单克隆起源学说 | | 文摘来源 | |   | | << 更多相关文摘 |
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