Conclusion: IL-18 in combination with IL-2 may increase the anti-tumor activity of NK92,which provides the experimental basis for immunotherapy of ovarian tumor with NK92 cells.
2(Hydroquinon2yl)5,10,15,20tetra(4hydroxylphenyl)porphyrinato zinc(Ⅱ)((Zn(Ⅱ)P)) and 2(hydroquinon2yl) 5,10,15,20tetra(4hydroxylphenyl)porphyrinato copper(Ⅱ)(Cu(Ⅱ)P) were synthesized and their antitumor activities were preliminarily studied.
The preliminary results showed that the antitumor activities of compound 5e was similar to that of 5-fluorouracil, while the acute toxicity of 5c (LD50=944.8my/kg)was about 8 times lower than that of 5-fluorouracil(LD50=117.2mg/kg).
The anticancer activity in vitro showed that Ⅱ_7, and Ⅲ_8 had the strongest inhibition and their IC_(50) against L1210 Leukemia cell were 3.910×10~(-3) μg/ml and 6.172×10~(-3) μg/ml.
2. To compare the cytotoxicity of ~(131)I-Rituximab with the single ~(131)I or Rituximab to the CD20-positive human B-lymphoma cell, and evaluate the anticancer activity of ~(131)I-Rituximab to human B-lymphoma.
Some new benzenesulfonamides, disubstituted sulfonylureas, and sulfonylthioureas substituted basically with 3-(2-thienyl or 3-pyridyl)-indeno[1,2-c]pyrazol(in)e counterpart were synthesized to be evaluated for their in vitro antitumor activity.
According to the protocol of the National Cancer Institute (NCI) in vitro disease-oriented human cells screening panel assay, 13 compounds showed promising broad spectrum antitumor activity.
Human LAK cells were prepared by culturing normal human peripheral blood mononuclear cells (PBMC) with or without rIL-2 and assayed for T cell surface markers as well as anti-tumor activity against PGin vitro and in nude mice.
A-LAK cells were treated with the supernatant of SMMC7721 cells which had been pretreated with PA and the changes of the proliferation and anti-tumor activity of A-LAK cells were investigated.
As important, these apoptosis-resistant γδ-T cells appear to retain major histocompatibility complex-unrestricted (innate) anti-tumor activity against a wide variety of human tumor cells both in vitro and in vivo.
The procedures developed for modification of functional groups in the adamantane skeleton provide a possibility of synthesis of compounds with potential anticancer activity.
A high-performance liquid chromatographic method is reported for the resolution of the enantiomers of a series of fused γ-lactams (2,7-diaza-3-oxo[3.3.0]octan-6-ones) with probable anti-HIV and anticancer activity.